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Pharmacology of montelukast sodium (Singulair), a potent and selective leukotriene D4 receptor antagonist

Canadian journal of physiology and pharmacology, 1995-02, Vol.73 (2), p.191

1995

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Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D4 receptor antagonist

Canadian journal of physiology and pharmacology, 1989-01, Vol.67 (1), p.17

1989

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L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor

Canadian journal of physiology and pharmacology, 1989-05, Vol.67 (5), p.456

1989

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Effects of a selective phosphodiesterase IV inhibitor (CDP-840) in a leukotriene-dependent non-human primate model of allergic asthma

Canadian journal of physiology and pharmacology, 1998-02, Vol.76 (2), p.210

1998

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Pharmacology of MK-0591 (3-[1-(4-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-yl-methoxy)- indol-2-yl]-2,2-dimethyl propanoic acid), a potent, orally active leukotriene biosynthesis inhibitor

Canadian journal of physiology and pharmacology, 1992-06, Vol.70 (6), p.799

1992

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Development of a novel series of styrylquinoline compounds as high-affinity leukotriene D4 receptor antagonists: synthetic and structure-activity studies leading to the discovery of (.+-.)-3-[[[3-[2-(7-chloro-2-quinolinyl)-(E)-ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]propionic acid

Journal of medicinal chemistry, 1992-10, Vol.35 (21), p.3832-3844

1992

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Substituted thiopyrano[2,3,4-c,d]indoles as potent, selective, and orally active inhibitors of 5-lipoxygenase. Synthesis and biological evaluation of L-691,816

Journal of medicinal chemistry, 1993-09, Vol.36 (19), p.2771-2787

1993

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Discovery of L-791,943: A potent, selective, non emetic and orally active phosphodiesterase-4 inhibitor

Bioorganic & medicinal chemistry letters, 2002-06, Vol.12 (11), p.1457-1461

2002

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Thiopyrano[2,3,4-cd]indoles as 5-Lipoxygenase Inhibitors: Synthesis, Biological Profile, and Resolution of 2-[2-[1-(4-Chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]ethoxy]butanoic Acid

Journal of medicinal chemistry, 1994-04, Vol.37 (8), p.1153-1164

1994

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The derivation of an inbred line of rats which develop asthma-like symptoms following challenge with aerosolized antigen

Immunology, 1981-01, Vol.42 (1), p.19-24

1981

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Development of L-689,065 - the prototype of a new class of potent 5-lipoxygenase inhibitors

Bioorganic & medicinal chemistry letters, 1992-12, Vol.2 (12), p.1699-1702

1992

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The discovery of L-699,392, a novel potent and orally active leukotriene D 4 receptor antagonist

Bioorganic & medicinal chemistry letters, 1994-02, Vol.4 (3), p.463-468

1994

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The discovery of a new structural class of potent orally active leukotriene D4 antagonists

Bioorganic & medicinal chemistry letters, 1992-09, Vol.2 (9), p.1141-1146

1992

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The discovery of L-699,392, a novel potent and orally active leukotriene D4 receptor antagonist

Bioorganic & medicinal chemistry letters, 1994-02, Vol.4 (3), p.463-468

1994

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Respiratory responses to leukotrienes and biogenic amines in normal and hyperreactive rats

The Journal of immunology (1950), 1983-07, Vol.131 (1), p.434

1983

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L-656,224 (7-chloro-2-[(4-methoxyphenyl)methyl]-3- methyl-5-propyl-4-benzofuranol): a novel, selective, orally active 5-lipoxygenase inhibitor

Canadian journal of physiology and pharmacology, 1987-12, Vol.65 (12), p.2441

1987

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Pharmacology of the leukotriene antagonist verlukast: the (R)-enantiomer of MK-571

Canadian journal of physiology and pharmacology, 1991-12, Vol.69 (12), p.1847

1991

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L-649,923, sodium (beta S, gamma R)-4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)-propylthio)- gamma-hydroxy-beta-methylbenzenebutanoate, a selective, orally active leukotriene receptor antagonist

Canadian journal of physiology and pharmacology, 1986-08, Vol.64 (8), p.1068

1986

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Discovery of MK-0476, a potent and orally active leukotriene D4 receptor antagonist devoid of peroxisomal enxyme induction

Bioorganic & medicinal chemistry letters, 1995-02, Vol.5 (3), p.283-288

1995

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A new class of leukotriene biosynthesis inhibitors: The development of ((4-(4-chlorophenyl)-1-(4-(2-quinolinylmethoxy)phenyl)butyl)thio)acetic acid, L-674,636

Bioorganic & medicinal chemistry letters, 1991, Vol.1 (11), p.645-648

1991

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Differing mechanisms for leukotriene d4-induced bronchoconstriction in guinea pigs following intravenous and aerosol administration

Prostaglandins, 1982-09, Vol.24 (3), p.419-432

1982

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Studies on the anti‐allergic action of N‐(3′,4′dimethoxycinnamoyl) anthranilic acid (N‐5′)

Allergy (Copenhagen), 1987-05, Vol.42 (4), p.284-290

1987

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The activity of synthetic leukotriene C-1 on guinea pig trachea and ileum

Prostaglandins, 1980-10, Vol.20 (4), p.717-728

1980

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The respiratory response of sensitized rats to challenge with antigen aerosols

Immunology, 1979-10, Vol.38 (2), p.385-392

1979

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Substituted (Pyridylmethoxy)naphthalenes as Potent and Orally Active 5-Lipoxygenase Inhibitors: Synthesis, Biological Profile, and Pharmacokinetics of L-739,010

Journal of medicinal chemistry, 1997-08, Vol.40 (18), p.2866-2875

1997

Volltextzugriff (PDF)

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Pharmacology of montelukast sodium (Singulair), a potent and selective leukotriene D4 receptor antagonist

Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D4 receptor antagonist

L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor

Effects of a selective phosphodiesterase IV inhibitor (CDP-840) in a leukotriene-dependent non-human primate model of allergic asthma

Pharmacology of MK-0591 (3-[1-(4-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-yl-methoxy)- indol-2-yl]-2,2-dimethyl propanoic acid), a potent, orally active leukotriene biosynthesis inhibitor

Substituted thiopyrano[2,3,4-c,d]indoles as potent, selective, and orally active inhibitors of 5-lipoxygenase. Synthesis and biological evaluation of L-691,816

Discovery of L-791,943: A potent, selective, non emetic and orally active phosphodiesterase-4 inhibitor

Thiopyrano[2,3,4-cd]indoles as 5-Lipoxygenase Inhibitors: Synthesis, Biological Profile, and Resolution of 2-[2-[1-(4-Chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]ethoxy]butanoic Acid

The derivation of an inbred line of rats which develop asthma-like symptoms following challenge with aerosolized antigen

Development of L-689,065 - the prototype of a new class of potent 5-lipoxygenase inhibitors

The discovery of L-699,392, a novel potent and orally active leukotriene D 4 receptor antagonist

The discovery of a new structural class of potent orally active leukotriene D4 antagonists

The discovery of L-699,392, a novel potent and orally active leukotriene D4 receptor antagonist

Respiratory responses to leukotrienes and biogenic amines in normal and hyperreactive rats

L-656,224 (7-chloro-2-[(4-methoxyphenyl)methyl]-3- methyl-5-propyl-4-benzofuranol): a novel, selective, orally active 5-lipoxygenase inhibitor

Pharmacology of the leukotriene antagonist verlukast: the (R)-enantiomer of MK-571

L-649,923, sodium (beta S, gamma R)-4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)-propylthio)- gamma-hydroxy-beta-methylbenzenebutanoate, a selective, orally active leukotriene receptor antagonist

Discovery of MK-0476, a potent and orally active leukotriene D4 receptor antagonist devoid of peroxisomal enxyme induction

A new class of leukotriene biosynthesis inhibitors: The development of ((4-(4-chlorophenyl)-1-(4-(2-quinolinylmethoxy)phenyl)butyl)thio)acetic acid, L-674,636

Differing mechanisms for leukotriene d4-induced bronchoconstriction in guinea pigs following intravenous and aerosol administration

Studies on the anti‐allergic action of N‐(3′,4′dimethoxycinnamoyl) anthranilic acid (N‐5′)

The activity of synthetic leukotriene C-1 on guinea pig trachea and ileum

The respiratory response of sensitized rats to challenge with antigen aerosols

Substituted (Pyridylmethoxy)naphthalenes as Potent and Orally Active 5-Lipoxygenase Inhibitors: Synthesis, Biological Profile, and Pharmacokinetics of L-739,010

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