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The crisis of no new antibiotics—what is the way forward?

The Lancet infectious diseases, 2012-03, Vol.12 (3), p.249-253

Piddock, Laura JV, Prof

2012

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Molecular mechanisms of antibiotic resistance

Nature reviews. Microbiology, 2015-01, Vol.13 (1), p.42-51

2015

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Understanding the mechanisms and drivers of antimicrobial resistance

The Lancet (British edition), 2016-01, Vol.387 (10014), p.176-187

2016

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Clinically Relevant Chromosomally Encoded Multidrug Resistance Efflux Pumps in Bacteria

Clinical Microbiology Reviews, 2006-04, Vol.19 (2), p.382-402

PIDDOCK, Laura J. V

2006

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Reflecting on the final report of the O'Neill Review on Antimicrobial Resistance

The Lancet infectious diseases, 2016-07, Vol.16 (7), p.767-768

Piddock, Laura J V

2016

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Loss of or inhibition of all multidrug resistance efflux pumps of Salmonella enterica serovar Typhimurium results in impaired ability to form a biofilm

Journal of antimicrobial chemotherapy, 2012-10, Vol.67 (10), p.2409-2417

2012

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Multidrug-resistance efflux pumps ? not just for resistance

Nature reviews. Microbiology, 2006-08, Vol.4 (8), p.629-636

Piddock, Laura J. V

2006

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Strategies to combat antimicrobial resistance: anti-plasmid and plasmid curing

FEMS microbiology reviews, 2018-11, Vol.42 (6), p.781-804

2018

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RamA Confers Multidrug Resistance in Salmonella enterica via Increased Expression of acrB, Which Is Inhibited by Chlorpromazine

Antimicrobial Agents and Chemotherapy, 2008-10, Vol.52 (10), p.3604-3611

2008

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How to Measure Export via Bacterial Multidrug Resistance Efflux Pumps

mBio, 2016-07, Vol.7 (4)

2016

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The role of combination therapy in the treatment of severe infections caused by carbapenem resistant gram-negatives: a systematic review of clinical studies

BMC infectious diseases, 2021-06, Vol.21 (1), p.1-545, Article 545

2021

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Chlorpromazine and Amitriptyline Are Substrates and Inhibitors of the AcrB Multidrug Efflux Pump

mBio, 2020-06, Vol.11 (3)

2020

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Perturbed structural dynamics underlie inhibition and altered efflux of the multidrug resistance pump AcrB

Nature communications, 2020-11, Vol.11 (1), p.5565-5565, Article 5565

2020

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Parallel evolutionary pathways to antibiotic resistance selected by biocide exposure

Journal of antimicrobial chemotherapy, 2015-08, Vol.70 (8), p.2241-2248

2015

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Structure, function and inhibition of RND efflux pumps in Gram-negative bacteria: an update

Current opinion in microbiology, 2009-10, Vol.12 (5), p.512-519

2009

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The multiple antibiotic resistance operon of enteric bacteria controls DNA repair and outer membrane integrity

Nature communications, 2017-11, Vol.8 (1), p.1444-12, Article 1444

2017

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AcrB drug-binding pocket substitution confers clinically relevant resistance and altered substrate specificity

Proceedings of the National Academy of Sciences - PNAS, 2015-03, Vol.112 (11), p.3511-3516

2015

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Inhibition of multidrug efflux as a strategy to prevent biofilm formation

Journal of antimicrobial chemotherapy, 2014-03, Vol.69 (3), p.673-681

2014

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Multidrug efflux pumps: structure, function and regulation

Nature reviews. Microbiology, 2018-09, Vol.16 (9), p.523-539

2018

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A 96-well plate fluorescence assay for assessment of cellular permeability and active efflux in Salmonella enterica serovar Typhimurium and Escherichia coli

Journal of antimicrobial chemotherapy, 2010-08, Vol.65 (8), p.1655-1663

2010

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RamA, which controls expression of the MDR efflux pump AcrAB-TolC, is regulated by the Lon protease

Journal of antimicrobial chemotherapy, 2014-03, Vol.69 (3), p.643-650

2014

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Choice of bacterial growth medium alters the transcriptome and phenotype of Salmonella enterica Serovar Typhimurium

PloS one, 2013-05, Vol.8 (5), p.e63912

2013

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The O-Antigen Epitope Governs Susceptibility to Colistin in Salmonella enterica

mBio, 2020-01, Vol.11 (1)

2020

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The global antibiotic research and development partnership (GARDP): researching and developing new antibiotics to meet global public health needs

MedChemComm, 2019, Vol.1 (8), p.1227-123

Piddock, Laura J. V

2019

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Persistence of Transferable Extended-Spectrum-β-Lactamase Resistance in the Absence of Antibiotic Pressure

Antimicrobial Agents and Chemotherapy, 2012-09, Vol.56 (9), p.4703-4706

2012

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The crisis of no new antibiotics—what is the way forward?

Molecular mechanisms of antibiotic resistance

Understanding the mechanisms and drivers of antimicrobial resistance

Clinically Relevant Chromosomally Encoded Multidrug Resistance Efflux Pumps in Bacteria

Reflecting on the final report of the O'Neill Review on Antimicrobial Resistance

Loss of or inhibition of all multidrug resistance efflux pumps of Salmonella enterica serovar Typhimurium results in impaired ability to form a biofilm

Multidrug-resistance efflux pumps ? not just for resistance

Strategies to combat antimicrobial resistance: anti-plasmid and plasmid curing

RamA Confers Multidrug Resistance in Salmonella enterica via Increased Expression of acrB, Which Is Inhibited by Chlorpromazine

How to Measure Export via Bacterial Multidrug Resistance Efflux Pumps

The role of combination therapy in the treatment of severe infections caused by carbapenem resistant gram-negatives: a systematic review of clinical studies

Chlorpromazine and Amitriptyline Are Substrates and Inhibitors of the AcrB Multidrug Efflux Pump

Perturbed structural dynamics underlie inhibition and altered efflux of the multidrug resistance pump AcrB

Parallel evolutionary pathways to antibiotic resistance selected by biocide exposure

Structure, function and inhibition of RND efflux pumps in Gram-negative bacteria: an update

The multiple antibiotic resistance operon of enteric bacteria controls DNA repair and outer membrane integrity

AcrB drug-binding pocket substitution confers clinically relevant resistance and altered substrate specificity

Inhibition of multidrug efflux as a strategy to prevent biofilm formation

Multidrug efflux pumps: structure, function and regulation

A 96-well plate fluorescence assay for assessment of cellular permeability and active efflux in Salmonella enterica serovar Typhimurium and Escherichia coli

RamA, which controls expression of the MDR efflux pump AcrAB-TolC, is regulated by the Lon protease

Choice of bacterial growth medium alters the transcriptome and phenotype of Salmonella enterica Serovar Typhimurium

The O-Antigen Epitope Governs Susceptibility to Colistin in Salmonella enterica

The global antibiotic research and development partnership (GARDP): researching and developing new antibiotics to meet global public health needs

Persistence of Transferable Extended-Spectrum-β-Lactamase Resistance in the Absence of Antibiotic Pressure

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