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Counteracting CAR T cell dysfunction

Oncogene, 2021-01, Vol.40 (2), p.421-435

2021

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Melanoma-Educated CD14+ Cells Acquire a Myeloid-Derived Suppressor Cell Phenotype through COX-2-Dependent Mechanisms

Cancer research (Chicago, Ill.), 2013-07, Vol.73 (13), p.3877-3887

2013

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In-depth plasma proteomics reveals increase in circulating PD-1 during anti-PD-1 immunotherapy in patients with metastatic cutaneous melanoma

Journal for immunotherapy of cancer, 2020-05, Vol.8 (1), p.e000204

2020

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Myeloid-derived suppressor cells and their role in CTLA-4 blockade therapy

Cancer Immunology, Immunotherapy, 2014-09, Vol.63 (9), p.977-983

2014

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IL-15, TIM-3 and NK cells subsets predict responsiveness to anti-CTLA-4 treatment in melanoma patients

Oncoimmunology, 2017-02, Vol.6 (2), p.e1261242-e1261242

2017

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Early Pharmacodynamic Changes Measured Using RNA Sequencing of Peripheral Blood from Patients in a Phase I Study with Mitazalimab, a Potent CD40 Agonistic Monoclonal Antibody

Cells (Basel, Switzerland), 2023-09, Vol.12 (19), p.2365

2023

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Checkpoint blockade for cancer therapy: revitalizing a suppressed immune system

Trends in molecular medicine, 2015-08, Vol.21 (8), p.482-491

2015

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Myeloid suppressors decrease melanoma survival by abating tumor-fighting T cells

Clinical cancer research, 2014-03, Vol.20 (6), p.1401-1403

2014

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Modulation of the Humoral Response to Dermatophagoides pteronyssinus Allergens in BALB/c Mice by Extract Modification and Adjuvant Use

International archives of allergy and immunology, 2012-03, Vol.157 (4), p.331-338

2012

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Self-Delivering RNAi Targeting PD-1 Improves Tumor-Specific T Cell Functionality for Adoptive Cell Therapy of Malignant Melanoma

Molecular therapy, 2018-06, Vol.26 (6), p.1482-1493

2018

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Interactions among myeloid regulatory cells in cancer

Cancer Immunology, Immunotherapy, 2019-04, Vol.68 (4), p.645-660

2019

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PD-1 checkpoint blockade in advanced melanoma patients: NK cells, monocytic subsets and host PD-L1 expression as predictive biomarker candidates

Oncoimmunology, 2020-01, Vol.9 (1), p.1786888-1786888

2020

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Ipilimumab treatment results in an early decrease in the frequency of circulating granulocytic myeloid-derived suppressor cells as well as their Arginase1 production

Cancer immunology research, 2013-09, Vol.1 (3), p.158-162

2013

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High expression of ID1 in monocytes is strongly associated with phenotypic and functional MDSC markers in advanced melanoma

Cancer Immunology, Immunotherapy, 2020-04, Vol.69 (4), p.513-522

2020

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Predicting anti-PD-1 responders in malignant melanoma from the frequency of S100A9+ monocytes in the blood

Journal for immunotherapy of cancer, 2021-05, Vol.9 (5), p.e002171

2021

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796 ALG.APV-527: a 5T4 tumor directed bispecific approach utilizing ADAPTIRTM technology designed for conditional 4-1BB T cell/NK agonism against solid tumors

Journal for immunotherapy of cancer, 2021-11, Vol.9 (Suppl 2), p.A831-A831

2021

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A highly infective Plasmodium vivax strain adapted to Aotus monkeys: Quantitative haematological and molecular determinations useful for P. vivax malaria vaccine development

Vaccine, 2003-09, Vol.21 (25-26), p.3930-3937

2003

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Ipilimumab treatment decreases monocytic MDSCs and increases CD8 effector memory T cells in long-term survivors with advanced melanoma

Oncotarget, 2017-03, Vol.8 (13), p.21539-21553

2017

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Molecular cloning and characterization of Cup a 4, a new allergen from Cupressus arizonica

Biochemical and biophysical research communications, 2010-10, Vol.401 (3), p.451-457

2010

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Modified Protocol for RNA Isolation from High Polysaccharide Containing Cupressus arizonica Pollen. Applications for RT-PCR and Phage Display Library Construction

Molecular biotechnology, 2010-02, Vol.44 (2), p.127-132

2010

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Ipilimumab treatment enhances CD4+ T cell activation while decreasing Treg and MDSC frequency in advanced melanoma patients

Journal for immunotherapy of cancer, 2014-11, Vol.2 (S3), p.P231-P231, Article P231

2014

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Mitazalimab in combination with mFOLFIRINOX in patients with metastatic pancreatic ductal adenocarcinoma (PDAC): Safety data from part of the OPTIMIZE-1 study

Journal of clinical oncology, 2022-06, Vol.40 (16_suppl), p.e16237-e16237

2022

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Analysis of calcium-induced conformational changes in calcium-binding allergens and quantitative determination of their IgE binding properties

Methods in molecular biology (Clifton, N.J.), 2013, Vol.963, p.115

2013

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Efficacy and safety of mitazalimab in combination with mFOLFIRINOX in patients with metastatic pancreatic ductal adenocarcinoma (mPDAC): An interim analysis of the optimize-1 phase 1b/2 study

Journal of clinical oncology, 2023-06, Vol.41 (16_suppl), p.4139-4139

2023

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Counteracting CAR T cell dysfunction

Melanoma-Educated CD14+ Cells Acquire a Myeloid-Derived Suppressor Cell Phenotype through COX-2-Dependent Mechanisms

In-depth plasma proteomics reveals increase in circulating PD-1 during anti-PD-1 immunotherapy in patients with metastatic cutaneous melanoma

Myeloid-derived suppressor cells and their role in CTLA-4 blockade therapy

IL-15, TIM-3 and NK cells subsets predict responsiveness to anti-CTLA-4 treatment in melanoma patients

Early Pharmacodynamic Changes Measured Using RNA Sequencing of Peripheral Blood from Patients in a Phase I Study with Mitazalimab, a Potent CD40 Agonistic Monoclonal Antibody

Checkpoint blockade for cancer therapy: revitalizing a suppressed immune system

Myeloid suppressors decrease melanoma survival by abating tumor-fighting T cells

Modulation of the Humoral Response to Dermatophagoides pteronyssinus Allergens in BALB/c Mice by Extract Modification and Adjuvant Use

Combining CD40 agonist mitazalimab with mFOLFIRINOX in previously untreated metastatic pancreatic ductal adenocarcinoma (OPTIMIZE-1): a single-arm, multicentre phase 1b/2 study

Self-Delivering RNAi Targeting PD-1 Improves Tumor-Specific T Cell Functionality for Adoptive Cell Therapy of Malignant Melanoma

Interactions among myeloid regulatory cells in cancer

PD-1 checkpoint blockade in advanced melanoma patients: NK cells, monocytic subsets and host PD-L1 expression as predictive biomarker candidates

Ipilimumab treatment results in an early decrease in the frequency of circulating granulocytic myeloid-derived suppressor cells as well as their Arginase1 production

High expression of ID1 in monocytes is strongly associated with phenotypic and functional MDSC markers in advanced melanoma

Predicting anti-PD-1 responders in malignant melanoma from the frequency of S100A9+ monocytes in the blood

796 ALG.APV-527: a 5T4 tumor directed bispecific approach utilizing ADAPTIRTM technology designed for conditional 4-1BB T cell/NK agonism against solid tumors

A highly infective Plasmodium vivax strain adapted to Aotus monkeys: Quantitative haematological and molecular determinations useful for P. vivax malaria vaccine development

Ipilimumab treatment decreases monocytic MDSCs and increases CD8 effector memory T cells in long-term survivors with advanced melanoma

Molecular cloning and characterization of Cup a 4, a new allergen from Cupressus arizonica

Modified Protocol for RNA Isolation from High Polysaccharide Containing Cupressus arizonica Pollen. Applications for RT-PCR and Phage Display Library Construction

Ipilimumab treatment enhances CD4+ T cell activation while decreasing Treg and MDSC frequency in advanced melanoma patients

Mitazalimab in combination with mFOLFIRINOX in patients with metastatic pancreatic ductal adenocarcinoma (PDAC): Safety data from part of the OPTIMIZE-1 study

Analysis of calcium-induced conformational changes in calcium-binding allergens and quantitative determination of their IgE binding properties

Efficacy and safety of mitazalimab in combination with mFOLFIRINOX in patients with metastatic pancreatic ductal adenocarcinoma (mPDAC): An interim analysis of the optimize-1 phase 1b/2 study

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