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Translational precision medicine: an industry perspective

Journal of translational medicine, 2021-06, Vol.19 (1), p.245-245, Article 245

2021

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The selective sphingosine 1-phosphate receptor 1 agonist ponesimod protects against lymphocyte-mediated tissue inflammation

The Journal of pharmacology and experimental therapeutics, 2011-05, Vol.337 (2), p.547

2011

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Therapeutic use of a selective S1P1 receptor modulator ponesimod in autoimmune diabetes

PloS one, 2013-10, Vol.8 (10), p.e77296-e77296

2013

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A randomized, double‐blind phase 1b study evaluating the safety, tolerability, pharmacokinetics and pharmacodynamics of the NLRP3 inhibitor selnoflast in patients with moderate to severe active ulcerative colitis

Clinical and translational medicine, 2023-11, Vol.13 (11), p.e1471-n/a

2023

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Macrophages exposed to Mycobacterium tuberculosis release chemokines able to recruit selected leucocyte subpopulations: focus on γδ cells

Immunology, 2003-03, Vol.108 (3), p.365-374

2003

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Expression of checkpoint molecules on myeloid-derived suppressor cells

Immunology letters, 2017-12, Vol.192, p.1-6

2017

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Chemokines and chemotaxis of leukocytes in infectious meningitis

Journal of neuroimmunology, 1998-05, Vol.85 (1), p.33-43

1998

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Discovery and In Vivo Evaluation of ACT-660602: A Potent and Selective Antagonist of the Chemokine Receptor CXCR3 for Autoimmune Diseases

Journal of medicinal chemistry, 2022-09, Vol.65 (17), p.11513-11532

2022

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High‐dimensional single‐cell proteomics analysis identifies immune checkpoint signatures and therapeutic targets in ulcerative colitis

European journal of immunology, 2019-03, Vol.49 (3), p.462-475

2019

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Mo1882 – Immune Cell and Checkpoint Signatures in Pbmc of Patients with Ulcerative Colitis

Gastroenterology (New York, N.Y. 1943), 2019-05, Vol.156 (6), p.S-873-S-874

2019

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β cells are responsible for CXCR3-mediated T-cell infiltration in insulitis

Nature medicine, 2002-12, Vol.8 (12), p.1414-1420

2002

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Therapeutic Potential of Ponesimod Alone and in Combination with Dimethyl Fumarate in Experimental Models of Multiple Sclerosis

Innovations in clinical neuroscience, 2019-03, Vol.16 (3-4), p.22-30

2019

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G-protein coupled receptors: drug targets of key importance

Current topics in medicinal chemistry, 2011, Vol.11 (6), p.608

2011

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The role of CCL21 in recruitment of T-precursor cells to fetal thymi

Blood, 2005-01, Vol.105 (1), p.31-39

2005

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Su1124 Evaluation of the CRTH2 Pathway As Therapeutic Approach for Eosinophilic Esophagitis

Gastroenterology (New York, N.Y. 1943), 2015-04, Vol.148 (4), p.S-415-S-415

2015

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Therapeutic Use of a Selective S1P.sub.1 Receptor Modulator Ponesimod in Autoimmune Diabetes

PloS one, 2013-10, Vol.8 (10), p.e77296

2013

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Cenerimod, a novel selective S1P1 receptor modulator with unique signaling properties

Pharmacology research & perspectives, 2017-12, Vol.5 (6), p.n/a

2017

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Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice

Nature immunology, 2002-11, Vol.3 (11), p.1102-1108

2002

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The chemokine receptor CXCR3 mediates rapid and shear‐resistant adhesion‐induction of effector T lymphocytes by the chemokines IP10 and Mig

European journal of immunology, 1998-03, Vol.28 (3), p.961-972

1998

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Cenerimod, a novel selective S1P 1 receptor modulator with unique signaling properties

Pharmacology research & perspectives, 2017-12, Vol.5 (6)

2017

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S.76. Selective S1P1 Receptor Agonist ACT-128800 Rapidly and Reversibly Reduces Blood Lymphocyte Count

Clinical immunology (Orlando, Fla.), 2009, Vol.131, p.S153-S153

2009

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CD4(+) T cell subsets during virus infection. Protective capacity depends on effector cytokine secretion and on migratory capability

The Journal of experimental medicine, 2000-06, Vol.191 (12), p.2159-2170

2000

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To stick or not to stick: the new leukocyte homing paradigm

Current opinion in cell biology, 1996-10, Vol.8 (5), p.714-723

1996

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Thymic atrophy in murine acute graft-versus-host disease is effected by impaired cell cycle progression of host pro-T and pre-T cells

Blood, 2000-07, Vol.96 (1), p.347-354

2000

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Endothelial vascular cell adhesion molecule 1 expression is suppressed by melanoma and carcinoma

The Journal of experimental medicine, 1995-02, Vol.181 (2), p.811-816

1995

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Translational precision medicine: an industry perspective

The selective sphingosine 1-phosphate receptor 1 agonist ponesimod protects against lymphocyte-mediated tissue inflammation

Therapeutic use of a selective S1P1 receptor modulator ponesimod in autoimmune diabetes

A randomized, double‐blind phase 1b study evaluating the safety, tolerability, pharmacokinetics and pharmacodynamics of the NLRP3 inhibitor selnoflast in patients with moderate to severe active ulcerative colitis

Macrophages exposed to Mycobacterium tuberculosis release chemokines able to recruit selected leucocyte subpopulations: focus on γδ cells

Expression of checkpoint molecules on myeloid-derived suppressor cells

Chemokines and chemotaxis of leukocytes in infectious meningitis

Discovery and In Vivo Evaluation of ACT-660602: A Potent and Selective Antagonist of the Chemokine Receptor CXCR3 for Autoimmune Diseases

High‐dimensional single‐cell proteomics analysis identifies immune checkpoint signatures and therapeutic targets in ulcerative colitis

Mo1882 – Immune Cell and Checkpoint Signatures in Pbmc of Patients with Ulcerative Colitis

β cells are responsible for CXCR3-mediated T-cell infiltration in insulitis

Therapeutic Potential of Ponesimod Alone and in Combination with Dimethyl Fumarate in Experimental Models of Multiple Sclerosis

G-protein coupled receptors: drug targets of key importance

The role of CCL21 in recruitment of T-precursor cells to fetal thymi

Su1124 Evaluation of the CRTH2 Pathway As Therapeutic Approach for Eosinophilic Esophagitis

Therapeutic Use of a Selective S1P.sub.1 Receptor Modulator Ponesimod in Autoimmune Diabetes

Cenerimod, a novel selective S1P1 receptor modulator with unique signaling properties

Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice

The chemokine receptor CXCR3 mediates rapid and shear‐resistant adhesion‐induction of effector T lymphocytes by the chemokines IP10 and Mig

Cenerimod, a novel selective S1P 1 receptor modulator with unique signaling properties

S.76. Selective S1P1 Receptor Agonist ACT-128800 Rapidly and Reversibly Reduces Blood Lymphocyte Count

CD4(+) T cell subsets during virus infection. Protective capacity depends on effector cytokine secretion and on migratory capability

To stick or not to stick: the new leukocyte homing paradigm

Thymic atrophy in murine acute graft-versus-host disease is effected by impaired cell cycle progression of host pro-T and pre-T cells

Endothelial vascular cell adhesion molecule 1 expression is suppressed by melanoma and carcinoma

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