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Membrane Sensor Histidine Kinases: Insights from Structural, Ligand and Inhibitor Studies of Full-Length Proteins and Signalling Domains for Antibiotic Discovery

Molecules (Basel, Switzerland), 2021-08, Vol.26 (16), p.5110

2021

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The discovery of hydrogen bonds in DNA and a re-evaluation of the 1948 Creeth two-chain model for its structure

Biochemical Society transactions, 2018-10, Vol.46 (5), p.1171-1182

2018

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Hydrodynamic Compatibility of Hyaluronic Acid and Tamarind Seed Polysaccharide as Ocular Mucin Supplements

Polymers, 2020-10, Vol.12 (10), p.2272

2020

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The gelatinase biosynthesis‐activating pheromone binds and stabilises the FsrB membrane protein in Enterococcus faecalis quorum sensing

FEBS letters, 2020-02, Vol.594 (3), p.553-563

2020

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Characterisation of mass distributions of solvent-fractionated lignins using analytical ultracentrifugation and size exclusion chromatography methods

Scientific reports, 2021-07, Vol.11 (1), p.13937-13937, Article 13937

2021

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Purification of bacterial membrane sensor kinases and biophysical methods for determination of their ligand and inhibitor interactions

Biochemical Society transactions, 2016-06, Vol.44 (3), p.810-823

2016

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Anti-HIV siamycin I directly inhibits autophosphorylation activity of the bacterial FsrC quorum sensor and other ATP-dependent enzyme activities

FEBS letters, 2011-09, Vol.585 (17), p.2660-2664

2011

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Ligand- and drug-binding studies of membrane proteins revealed through circular dichroism spectroscopy

Biochimica et biophysica acta, 2014-01, Vol.1838 (1), p.34-42

2014

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Glycoconjugate vaccines: some observations on carrier and production methods

Biotechnology & genetic engineering reviews, 2019-07, Vol.35 (2), p.93-125

2019

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Antimicrobial resistance (AMR) nanomachines—mechanisms for fluoroquinolone and glycopeptide recognition, efflux and/or deactivation

Biophysical reviews, 2018-04, Vol.10 (2), p.347-362

2018

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The antibiotic vancomycin induces complexation and aggregation of gastrointestinal and submaxillary mucins

Scientific reports, 2020-01, Vol.10 (1), p.960, Article 960

2020

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Full hydrodynamic reversibility of the weak dimerization of vancomycin and elucidation of its interaction with VanS monomers at clinical concentration

Scientific reports, 2017-10, Vol.7 (1), p.12697-10, Article 12697

2017

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Structural and biophysical characterisation of membrane protein–ligand binding

Biochimica et biophysica acta, 2014-01, Vol.1838 (1), p.1-2

Phillips-Jones, Mary K.

2014

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Solution structure and DNA binding of the effector domain from the global regulator PrrA (RegA) from Rhodobacter sphaeroides: insights into DNA binding specificity

Nucleic acids research, 2003-12, Vol.31 (23), p.6778-6787

2003

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Hydrodynamics of the VanA-type VanS histidine kinase: an extended solution conformation and first evidence for interactions with vancomycin

Scientific reports, 2017-04, Vol.7 (1), p.46180, Article 46180

2017

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Interactions of the intact FsrC membrane histidine kinase with its pheromone ligand GBAP revealed through synchrotron radiation circular dichroism

Biochimica et biophysica acta, 2012-07, Vol.1818 (7), p.1595-1602

2012

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Tapping into Synchrotron and Benchtop Circular Dichroism Spectroscopy for Expanding Studies of Complex Polysaccharides and their Interactions in Anoxic Archaeological Wood

Heritage, 2019-03, Vol.2 (1), p.121-134

2019

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Interactions of the intact FsrC membrane histidine kinase with the tricyclic peptide inhibitor siamycin I revealed through synchrotron radiation circular dichroism

Physical chemistry chemical physics : PCCP, 2013-01, Vol.15 (2), p.444-447

2013

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Production of membrane proteins for characterisation of their pheromone-sensing and antimicrobial resistance functions

European biophysics journal, 2018-10, Vol.47 (7), p.723-737

2018

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Structure of the response regulator VicR DNA-binding domain

Acta crystallographica. Section D, Biological crystallography., 2007-02, Vol.63 (2), p.266-269

2007

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Use of a lux reporter system for monitoring rapid changes in α-toxin gene expression in Clostridium perfringens during growth

FEMS microbiology letters, 2000-07, Vol.188 (1), p.29-33

Phillips-Jones, Mary K.

2000

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Expression, Purification and Characterisation of Full-length Histidine Protein Kinase RegB from Rhodobacter sphaeroides

Journal of molecular biology, 2002-07, Vol.320 (2), p.201-213

2002

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Expression, purification and activities of the entire family of intact membrane sensor kinases from Enterococcus faecalis

Molecular membrane biology, 2008-01, Vol.25 (6-7), p.449-473

2008

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Activation of the Global Gene Regulator PrrA (RegA) from Rhodobacter sphaeroides

Biochemistry (Easton), 2006-06, Vol.45 (25), p.7872-7881

2006

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WITHDRAWN: Characterisation of the Intact Sensor Kinase VicK from Enterococcus faecalis: Direct Evidence for YycH as a Potent Modulating Signal in vitro

Journal of molecular biology, 2007-04

2007

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Membrane Sensor Histidine Kinases: Insights from Structural, Ligand and Inhibitor Studies of Full-Length Proteins and Signalling Domains for Antibiotic Discovery

The discovery of hydrogen bonds in DNA and a re-evaluation of the 1948 Creeth two-chain model for its structure

Hydrodynamic Compatibility of Hyaluronic Acid and Tamarind Seed Polysaccharide as Ocular Mucin Supplements

The gelatinase biosynthesis‐activating pheromone binds and stabilises the FsrB membrane protein in Enterococcus faecalis quorum sensing

Characterisation of mass distributions of solvent-fractionated lignins using analytical ultracentrifugation and size exclusion chromatography methods

Purification of bacterial membrane sensor kinases and biophysical methods for determination of their ligand and inhibitor interactions

Anti-HIV siamycin I directly inhibits autophosphorylation activity of the bacterial FsrC quorum sensor and other ATP-dependent enzyme activities

Ligand- and drug-binding studies of membrane proteins revealed through circular dichroism spectroscopy

Glycoconjugate vaccines: some observations on carrier and production methods

Antimicrobial resistance (AMR) nanomachines—mechanisms for fluoroquinolone and glycopeptide recognition, efflux and/or deactivation

The antibiotic vancomycin induces complexation and aggregation of gastrointestinal and submaxillary mucins

Full hydrodynamic reversibility of the weak dimerization of vancomycin and elucidation of its interaction with VanS monomers at clinical concentration

Structural and biophysical characterisation of membrane protein–ligand binding

Solution structure and DNA binding of the effector domain from the global regulator PrrA (RegA) from Rhodobacter sphaeroides: insights into DNA binding specificity

Hydrodynamics of the VanA-type VanS histidine kinase: an extended solution conformation and first evidence for interactions with vancomycin

Interactions of the intact FsrC membrane histidine kinase with its pheromone ligand GBAP revealed through synchrotron radiation circular dichroism

Tapping into Synchrotron and Benchtop Circular Dichroism Spectroscopy for Expanding Studies of Complex Polysaccharides and their Interactions in Anoxic Archaeological Wood

Interactions of the intact FsrC membrane histidine kinase with the tricyclic peptide inhibitor siamycin I revealed through synchrotron radiation circular dichroism

Production of membrane proteins for characterisation of their pheromone-sensing and antimicrobial resistance functions

Structure of the response regulator VicR DNA-binding domain

Use of a lux reporter system for monitoring rapid changes in α-toxin gene expression in Clostridium perfringens during growth

Expression, Purification and Characterisation of Full-length Histidine Protein Kinase RegB from Rhodobacter sphaeroides

Expression, purification and activities of the entire family of intact membrane sensor kinases from Enterococcus faecalis

Activation of the Global Gene Regulator PrrA (RegA) from Rhodobacter sphaeroides

WITHDRAWN: Characterisation of the Intact Sensor Kinase VicK from Enterococcus faecalis: Direct Evidence for YycH as a Potent Modulating Signal in vitro

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