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Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds

Proceedings of the National Academy of Sciences - PNAS, 2019-02, Vol.116 (7), p.2545-2550

2019

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Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy

Nature genetics, 2008-06, Vol.40 (6), p.789-793

2008

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Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment

Nature communications, 2018-08, Vol.9 (1), p.3169-12, Article 3169

2018

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Rewriting nature’s assembly manual for a ssRNA virus

Proceedings of the National Academy of Sciences - PNAS, 2017-11, Vol.114 (46), p.12255-12260

2017

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Unique architecture of thermophilic archaeal virus APBV1 and its genome packaging

Nature communications, 2017-11, Vol.8 (1), p.1436-6, Article 1436

2017

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Packaging signals in single-stranded RNA viruses: nature’s alternative to a purely electrostatic assembly mechanism

Journal of biological physics, 2013-03, Vol.39 (2), p.277-287

2013

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Structures of replication initiation proteins from staphylococcal antibiotic resistance plasmids reveal protein asymmetry and flexibility are necessary for replication

Nucleic acids research, 2016-03, Vol.44 (5), p.2417-2428

2016

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Revealing the density of encoded functions in a viral RNA

Proceedings of the National Academy of Sciences - PNAS, 2015-02, Vol.112 (7), p.2227-2232

2015

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Van der Waals Interactions Dominate Ligand−Protein Association in a Protein Binding Site Occluded from Solvent Water

Journal of the American Chemical Society, 2005-08, Vol.127 (33), p.11827-11834

2005

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Reaction Mechanism of N‑Acetylneuraminic Acid Lyase Revealed by a Combination of Crystallography, QM/MM Simulation, and Mutagenesis

ACS chemical biology, 2014-04, Vol.9 (4), p.1025-1032

2014

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Importance of the Active Site “Canopy” Residues in an O2‑Tolerant [NiFe]-Hydrogenase

Biochemistry (Easton), 2017-01, Vol.56 (1), p.132-142

2017

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A Versatile Strategy for Production of Membrane Proteins with Diverse Topologies: Application to Investigation of Bacterial Homologues of Human Divalent Metal Ion and Nucleoside Transporters

PloS one, 2015-11, Vol.10 (11), p.e0143010

2015

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The structural basis of Holliday junction resolution by T7 endonuclease I

Nature, 2007-10, Vol.449 (7162), p.621-624

2007

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Degenerate RNA Packaging Signals in the Genome of Satellite Tobacco Necrosis Virus: Implications for the Assembly of a T = 1 Capsid

Journal of molecular biology, 2011-10, Vol.413 (1), p.51-65

2011

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Purification, characterization, and identification of a novel bifunctional catalase-phenol oxidase from Scytalidium thermophilum

Applied microbiology and biotechnology, 2008-06, Vol.79 (3), p.407-415

2008

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The Stacking Tryptophan of Galactose Oxidase: A Second-Coordination Sphere Residue that Has Profound Effects on Tyrosyl Radical Behavior and Enzyme Catalysis

Biochemistry (Easton), 2007-04, Vol.46 (15), p.4606-4618

2007

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Structure, recombinant expression and mutagenesis studies of the catalase with oxidase activity from Scytalidium thermophilum

Acta crystallographica. Section D, Biological crystallography., 2013-03, Vol.69 (3), p.398-408

2013

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BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions

eLife, 2018-07, Vol.7

2018

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Strong Solute−Solute Dispersive Interactions in a Protein−Ligand Complex

Journal of the American Chemical Society, 2005-12, Vol.127 (48), p.17061-17067

2005

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Exploring the Roles of the Metal Ions in Escherichia coli Copper Amine Oxidase

Biochemistry (Easton), 2010-02, Vol.49 (6), p.1268-1280

2010

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Cross-Link Formation of the Cysteine 228−Tyrosine 272 Catalytic Cofactor of Galactose Oxidase Does Not Require Dioxygen

Biochemistry (Easton), 2008-09, Vol.47 (39), p.10428-10439

2008

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Mechanism of hydrogen activation by [NiFe] hydrogenases

Nature chemical biology, 2016-01, Vol.12 (1), p.46-50

2016

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Thermodynamics of Binding of 2-Methoxy-3-isopropylpyrazine and 2-Methoxy-3-isobutylpyrazine to the Major Urinary Protein

Journal of the American Chemical Society, 2004-02, Vol.126 (6), p.1675-1681

2004

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5-Formylcytosine does not change the global structure of DNA

Nature structural & molecular biology, 2017-06, Vol.24 (6), p.544-552

2017

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Crystal Structure of Monomeric Human β-2-Microglobulin Reveals Clues to Its Amyloidogenic Properties

Proceedings of the National Academy of Sciences - PNAS, 2002-07, Vol.99 (15), p.9771-9776

2002

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Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds

Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy

Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment

Rewriting nature’s assembly manual for a ssRNA virus

Unique architecture of thermophilic archaeal virus APBV1 and its genome packaging

Packaging signals in single-stranded RNA viruses: nature’s alternative to a purely electrostatic assembly mechanism

Structures of replication initiation proteins from staphylococcal antibiotic resistance plasmids reveal protein asymmetry and flexibility are necessary for replication

Revealing the density of encoded functions in a viral RNA

Van der Waals Interactions Dominate Ligand−Protein Association in a Protein Binding Site Occluded from Solvent Water

Reaction Mechanism of N‑Acetylneuraminic Acid Lyase Revealed by a Combination of Crystallography, QM/MM Simulation, and Mutagenesis

Importance of the Active Site “Canopy” Residues in an O2‑Tolerant [NiFe]-Hydrogenase

A Versatile Strategy for Production of Membrane Proteins with Diverse Topologies: Application to Investigation of Bacterial Homologues of Human Divalent Metal Ion and Nucleoside Transporters

The structural basis of Holliday junction resolution by T7 endonuclease I

Degenerate RNA Packaging Signals in the Genome of Satellite Tobacco Necrosis Virus: Implications for the Assembly of a T = 1 Capsid

Purification, characterization, and identification of a novel bifunctional catalase-phenol oxidase from Scytalidium thermophilum

The Stacking Tryptophan of Galactose Oxidase: A Second-Coordination Sphere Residue that Has Profound Effects on Tyrosyl Radical Behavior and Enzyme Catalysis

Structure, recombinant expression and mutagenesis studies of the catalase with oxidase activity from Scytalidium thermophilum

BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions

Strong Solute−Solute Dispersive Interactions in a Protein−Ligand Complex

Exploring the Roles of the Metal Ions in Escherichia coli Copper Amine Oxidase

Cross-Link Formation of the Cysteine 228−Tyrosine 272 Catalytic Cofactor of Galactose Oxidase Does Not Require Dioxygen

Mechanism of hydrogen activation by [NiFe] hydrogenases

Thermodynamics of Binding of 2-Methoxy-3-isopropylpyrazine and 2-Methoxy-3-isobutylpyrazine to the Major Urinary Protein

5-Formylcytosine does not change the global structure of DNA

Crystal Structure of Monomeric Human β-2-Microglobulin Reveals Clues to Its Amyloidogenic Properties

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