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Mitoxantrone, More than Just Another Topoisomerase II Poison

Medicinal research reviews, 2016-03, Vol.36 (2), p.248-299

2016

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Factors determining the stability, size distribution, and cellular accumulation of small, monodisperse chitosan nanoparticles as candidate vectors for anticancer drug delivery: application to the passive encapsulation of [(14)C]-doxorubicin

Nanotechnology, science and applications, 2015-01, Vol.8 (Issue 1), p.67-80

2015

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Understanding mass spectrometry images: complexity to clarity with machine learning

Biopolymers, 2021-04, Vol.112 (4), p.e23400-n/a

2021

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Potential Therapeutic Advantages of Doxorubicin when Activated by Formaldehyde to Function as a DNA Adduct-Forming Agent

Current topics in medicinal chemistry, 2015-05, Vol.15 (14), p.1409

2015

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Doxorubicin-DNA adducts induce a non-topoisomerase II-mediated form of cell death

Cancer research (Chicago, Ill.), 2006-05, Vol.66 (9), p.4863-4871

2006

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An evaluation of the interaction of pixantrone with formaldehyde-releasing drugs in cancer cells

Cancer chemotherapy and pharmacology, 2022-06, Vol.89 (6), p.773-784

2022

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Development of an automated assay for accelerated in vitro detection of DNA adduct-inducing and crosslinking agents

Bioorganic & medicinal chemistry letters, 2021-03, Vol.35, p.127813-127813, Article 127813

2021

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Activation of DNA damage response pathways as a consequence of anthracycline-DNA adduct formation

Biochemical pharmacology, 2012-06, Vol.83 (12), p.1602-1612

2012

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Disparate impact of butyroyloxymethyl diethylphosphate (AN-7), a histone deacetylase inhibitor, and doxorubicin in mice bearing a mammary tumor

PloS one, 2012-02, Vol.7 (2), p.e31393-e31393

2012

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Formaldehyde-activated WEHI-150 induces DNA interstrand crosslinks with unique structural features

Bioorganic & medicinal chemistry, 2020-02, Vol.28 (3), p.115260, Article 115260

2020

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The Power and Potential of Doxorubicin‐DNA Adducts

IUBMB life, 2005-03, Vol.57 (2), p.73-81

2005

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Encapsulation of Mitoxantrone within Cucurbit[8]uril Decreases Toxicity and Enhances Survival in a Mouse Model of Cancer

ACS medicinal chemistry letters, 2017-05, Vol.8 (5), p.538-542

2017

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Detection of Adriamycin-DNA adducts by accelerator mass spectrometry at clinically relevant Adriamycin concentrations

Nucleic acids research, 2008-09, Vol.36 (16), p.e100

2008

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A novel valproic acid prodrug as an anticancer agent that enhances doxorubicin anticancer activity and protects normal cells against its toxicity in vitro and in vivo

Biochemical pharmacology, 2014-03, Vol.88 (2), p.158-168

2014

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Isolation and structural analysis of the covalent adduct formed between a bis-amino mitoxantrone analogue and DNA: a pathway to major-minor groove cross-linked adducts

Organic & biomolecular chemistry, 2016-11, Vol.14 (43), p.10217-10221

2016

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Binding of pixantrone to DNA at CpA dinucleotide sequences and bulge structures

Organic & biomolecular chemistry, 2015-06, Vol.13 (21), p.5972-5982

2015

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The histone deacetylase inhibitor butyroyloxymethyl diethylphosphate (AN-7) protects normal cells against toxicity of anticancer agents while augmenting their anticancer activity

Investigational new drugs, 2012-02, Vol.30 (1), p.130-143

2012

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DNA repair in response to anthracycline–DNA adducts: A role for both homologous recombination and nucleotide excision repair

Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 2008-02, Vol.638 (1), p.110-121

2008

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Reversible and formaldehyde-mediated covalent binding of a bis-amino mitoxantrone analogue to DNA

Organic & biomolecular chemistry, 2016-05, Vol.14 (2), p.4728-4738

2016

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Operational efficiency and effectiveness measurement

International journal of operations & production management, 2001-11, Vol.21 (11), p.1404-1416

2001

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Design, synthesis, and DNA sequence selectivity of formaldehyde-mediated DNA-adducts of the novel N-(4-aminobutyl) acridine-4-carboxamide

Bioorganic & medicinal chemistry letters, 2014-12, Vol.24 (24), p.5710-5715

2014

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Formaldehyde-Activated Pixantrone Is a Monofunctional DNA Alkylator That Binds Selectively to CpG and CpA Doublets

Molecular pharmacology, 2008-07, Vol.74 (1), p.184-194

2008

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ABT-737 overcomes Bcl-2 mediated resistance to doxorubicin–DNA adducts

Biochemical pharmacology, 2010-02, Vol.79 (3), p.339-349

2010

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The cardio-protecting agent and topoisomerase II catalytic inhibitor sobuzoxane enhances doxorubicin-DNA adduct mediated cytotoxicity

Cancer chemotherapy and pharmacology, 2008-04, Vol.61 (5), p.739-749

2008

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Gemcitabine Potentiates Cisplatin Cytotoxicity and Inhibits Repair of Cisplatin-DNA Damage in Ovarian Cancer Cell Lines

Molecular pharmacology, 2003-04, Vol.63 (4), p.862-869

2003

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Mitoxantrone, More than Just Another Topoisomerase II Poison

Factors determining the stability, size distribution, and cellular accumulation of small, monodisperse chitosan nanoparticles as candidate vectors for anticancer drug delivery: application to the passive encapsulation of [(14)C]-doxorubicin

Understanding mass spectrometry images: complexity to clarity with machine learning

Potential Therapeutic Advantages of Doxorubicin when Activated by Formaldehyde to Function as a DNA Adduct-Forming Agent

Doxorubicin-DNA adducts induce a non-topoisomerase II-mediated form of cell death

An evaluation of the interaction of pixantrone with formaldehyde-releasing drugs in cancer cells

Development of an automated assay for accelerated in vitro detection of DNA adduct-inducing and crosslinking agents

Activation of DNA damage response pathways as a consequence of anthracycline-DNA adduct formation

Disparate impact of butyroyloxymethyl diethylphosphate (AN-7), a histone deacetylase inhibitor, and doxorubicin in mice bearing a mammary tumor

Formaldehyde-activated WEHI-150 induces DNA interstrand crosslinks with unique structural features

The Power and Potential of Doxorubicin‐DNA Adducts

Encapsulation of Mitoxantrone within Cucurbit[8]uril Decreases Toxicity and Enhances Survival in a Mouse Model of Cancer

Detection of Adriamycin-DNA adducts by accelerator mass spectrometry at clinically relevant Adriamycin concentrations

A novel valproic acid prodrug as an anticancer agent that enhances doxorubicin anticancer activity and protects normal cells against its toxicity in vitro and in vivo

Isolation and structural analysis of the covalent adduct formed between a bis-amino mitoxantrone analogue and DNA: a pathway to major-minor groove cross-linked adducts

Binding of pixantrone to DNA at CpA dinucleotide sequences and bulge structures

The histone deacetylase inhibitor butyroyloxymethyl diethylphosphate (AN-7) protects normal cells against toxicity of anticancer agents while augmenting their anticancer activity

DNA repair in response to anthracycline–DNA adducts: A role for both homologous recombination and nucleotide excision repair

Reversible and formaldehyde-mediated covalent binding of a bis-amino mitoxantrone analogue to DNA

Operational efficiency and effectiveness measurement

Design, synthesis, and DNA sequence selectivity of formaldehyde-mediated DNA-adducts of the novel N-(4-aminobutyl) acridine-4-carboxamide

Formaldehyde-Activated Pixantrone Is a Monofunctional DNA Alkylator That Binds Selectively to CpG and CpA Doublets

ABT-737 overcomes Bcl-2 mediated resistance to doxorubicin–DNA adducts

The cardio-protecting agent and topoisomerase II catalytic inhibitor sobuzoxane enhances doxorubicin-DNA adduct mediated cytotoxicity

Gemcitabine Potentiates Cisplatin Cytotoxicity and Inhibits Repair of Cisplatin-DNA Damage in Ovarian Cancer Cell Lines

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