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Preclinical pharmacological profile of the selective 5-HT1F receptor agonist lasmiditan

Cephalalgia, 2010-10, Vol.30 (10), p.1159-1169

2010

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Use of LC/MS to assess brain tracer distribution in preclinical, in vivo receptor occupancy studies: Dopamine D2, serotonin 2A and NK-1 receptors as examples

Life sciences (1973), 2005-12, Vol.78 (4), p.340-346

2005

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Comparison of rat dopamine D2 receptor occupancy for a series of antipsychotic drugs measured using radiolabeled or nonlabeled raclopride tracer

Life sciences (1973), 2006-05, Vol.78 (26), p.3007-3012

2006

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Pharmacological characterization of the competitive GLUK5 receptor antagonist decahydroisoquinoline LY466195 in vitro and in vivo

The Journal of pharmacology and experimental therapeutics, 2006-08, Vol.318 (2), p.772

2006

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Minocycline Prevents Nigrostriatal Dopaminergic Neurodegeneration in the MPTP Model of Parkinson's Disease

Proceedings of the National Academy of Sciences - PNAS, 2001-12, Vol.98 (25), p.14669-14674

2001

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Endocannabinoids Activate Transient Receptor Potential Vanilloid 1 Receptors to Reduce Hyperdopaminergia-Related Hyperactivity: Therapeutic Implications

Biological psychiatry (1969), 2006-03, Vol.59 (6), p.508-515

2006

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Ethyl (3S,4aR,6S,8aR)-6-(4-Ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso- quinoline-3-carboxylic Ester: A Prodrug of a GluR5 Kainate Receptor Antagonist Active in Two Animal Models of Acute Migraine

Journal of medicinal chemistry, 2002-09, Vol.45 (20), p.4383-4386

2002

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The PET Radioligand [11C]MePPEP Binds Reversibly and with High Specific Signal to Cannabinoid CB1 Receptors in Nonhuman Primate Brain

Neuropsychopharmacology (New York, N.Y.), 2008-01, Vol.33 (2), p.259-269

2008

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Chronic coadministration of olanzapine and fluoxetine activates locus coeruleus neurons in rats : implications for bipolar disorder

Psychopharmacologia, 2005-08, Vol.181 (1), p.126-133

2005

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In vivo rat brain opioid receptor binding of LY255582 assessed with a novel method using LC/MS/MS and the administration of three tracers simultaneously

Life sciences (1973), 2007-10, Vol.81 (17-18), p.1389-1396

2007

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The relationship of in vivo central CB1 receptor occupancy to changes in cortical monoamine release and feeding elicited by CB1 receptor antagonists in rats

Psychopharmacologia, 2006, Vol.184 (1), p.26-35

2006

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Fluoxetine administration potentiates the effect of olanzapine on locus coeruleus neuronal activity

Biological psychiatry (1969), 2004-06, Vol.55 (11), p.1103-1109

2004

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Discovery of a Potent, Dual Serotonin and Norepinephrine Reuptake Inhibitor

ACS medicinal chemistry letters, 2013-06, Vol.4 (6), p.560-564

2013

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5-HT1F receptor agonists inhibit neurogenic dural inflammation in guinea pigs

Neuroreport, 1997-07, Vol.8 (9), p.2237-2239

1997

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Novel Potent 5-HT1F Receptor Agonists: Structure−Activity Studies of a Series of Substituted N-[3-(1-Methyl-4-piperidinyl)-1H-pyrrolo[3,2-b]pyridin-5-yl]amides

Journal of medicinal chemistry, 2003-07, Vol.46 (14), p.3060-3071

2003

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Characterization of LY344864 as a pharmacological tool to study 5-HT1F receptors: binding affinities, brain penetration and activity in the neurogenic dural inflammation model of migraine

Life sciences (1973), 1997-10, Vol.61 (21), p.2117-2126

1997

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N-[3-(2-Dimethylaminoethyl)-2-methyl-1H- indol-5-yl]-4-fluorobenzamide: A Potent, Selective, and Orally Active 5-HT1F Receptor Agonist Potentially Useful for Migraine Therapy

Journal of medicinal chemistry, 2001-11, Vol.44 (24), p.4031-4034

2001

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Serotonin in migraine: theories, animal models and emerging therapies

Progress in drug research, 1998, Vol.51, p.219

1998

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Benzylamine antioxidants: relationship between structure, peroxyl radical scavenging, lipid peroxidation inhibition and cytoprotection

Journal of medicinal chemistry, 1993-04, Vol.36 (9), p.1262-1271

1993

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Dopamine depletion protects striatal neurons from ischemia-induced cell death

Life sciences (1973), 1988, Vol.42 (6), p.707-713

1988

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A fluorescence-based method for assessing dural protein extravasation induced by trigeminal ganglion stimulation

Journal of neuroscience methods, 1998-06, Vol.81 (1), p.19-24

1998

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Measurement of striatal H2O2 by microdialysis following global forebrain ischemia and reperfusion in the rat : correlation with the cytotoxic potential of H2O2 in vitro

Brain research, 1995-02, Vol.671 (2), p.181-186

1995

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Ischemia increases tissue and decreases extracellular levels of acid dopamine metabolites in the rat striatum: Further evidence for active transport of metabolites

Life sciences (1973), 1995-02, Vol.56 (13), p.1135-1141

1995

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Release of histamine in rat hypothalamus and corpus striatum in vivo

Brain research, 1990-03, Vol.512 (1), p.95-101

1990

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Preclinical pharmacological profile of the selective 5-HT1F receptor agonist lasmiditan

Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas

Use of LC/MS to assess brain tracer distribution in preclinical, in vivo receptor occupancy studies: Dopamine D2, serotonin 2A and NK-1 receptors as examples

Comparison of rat dopamine D2 receptor occupancy for a series of antipsychotic drugs measured using radiolabeled or nonlabeled raclopride tracer

Pharmacological characterization of the competitive GLUK5 receptor antagonist decahydroisoquinoline LY466195 in vitro and in vivo

Minocycline Prevents Nigrostriatal Dopaminergic Neurodegeneration in the MPTP Model of Parkinson's Disease

Endocannabinoids Activate Transient Receptor Potential Vanilloid 1 Receptors to Reduce Hyperdopaminergia-Related Hyperactivity: Therapeutic Implications

Ethyl (3S,4aR,6S,8aR)-6-(4-Ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso- quinoline-3-carboxylic Ester: A Prodrug of a GluR5 Kainate Receptor Antagonist Active in Two Animal Models of Acute Migraine

The PET Radioligand [11C]MePPEP Binds Reversibly and with High Specific Signal to Cannabinoid CB1 Receptors in Nonhuman Primate Brain

Chronic coadministration of olanzapine and fluoxetine activates locus coeruleus neurons in rats : implications for bipolar disorder

In vivo rat brain opioid receptor binding of LY255582 assessed with a novel method using LC/MS/MS and the administration of three tracers simultaneously

The relationship of in vivo central CB1 receptor occupancy to changes in cortical monoamine release and feeding elicited by CB1 receptor antagonists in rats

Fluoxetine administration potentiates the effect of olanzapine on locus coeruleus neuronal activity

Discovery of a Potent, Dual Serotonin and Norepinephrine Reuptake Inhibitor

5-HT1F receptor agonists inhibit neurogenic dural inflammation in guinea pigs

Novel Potent 5-HT1F Receptor Agonists: Structure−Activity Studies of a Series of Substituted N-[3-(1-Methyl-4-piperidinyl)-1H-pyrrolo[3,2-b]pyridin-5-yl]amides

Characterization of LY344864 as a pharmacological tool to study 5-HT1F receptors: binding affinities, brain penetration and activity in the neurogenic dural inflammation model of migraine

N-[3-(2-Dimethylaminoethyl)-2-methyl-1H- indol-5-yl]-4-fluorobenzamide: A Potent, Selective, and Orally Active 5-HT1F Receptor Agonist Potentially Useful for Migraine Therapy

Serotonin in migraine: theories, animal models and emerging therapies

Benzylamine antioxidants: relationship between structure, peroxyl radical scavenging, lipid peroxidation inhibition and cytoprotection

Dopamine depletion protects striatal neurons from ischemia-induced cell death

A fluorescence-based method for assessing dural protein extravasation induced by trigeminal ganglion stimulation

Measurement of striatal H2O2 by microdialysis following global forebrain ischemia and reperfusion in the rat : correlation with the cytotoxic potential of H2O2 in vitro

Ischemia increases tissue and decreases extracellular levels of acid dopamine metabolites in the rat striatum: Further evidence for active transport of metabolites

Release of histamine in rat hypothalamus and corpus striatum in vivo

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