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Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange

Proceedings of the National Academy of Sciences - PNAS, 2014-03, Vol.111 (9), p.3401-3406

2014

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Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRASG12C Inhibitor

Journal of medicinal chemistry, 2022-11, Vol.65 (21), p.14614-14629

2022

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Structure-based Design of High Affinity Peptides Inhibiting the Interaction of p53 with MDM2 and MDMX

The Journal of biological chemistry, 2010-01, Vol.285 (3), p.2174-2183

2010

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Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS

Journal of medicinal chemistry, 2018-10, Vol.61 (19), p.8875-8894

2018

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Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity

Cell reports (Cambridge), 2019-03, Vol.26 (11), p.2916-2928.e13

2019

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Physical Therapy for Gait, Balance, and Cognition in Individuals with Cognitive Impairment: A Retrospective Analysis

Rehabilitation research and practice, 2020-11, Vol.2020, p.8861004-12

2020

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Structural Basis for the Substrate Specificity of Tobacco Etch Virus Protease

The Journal of biological chemistry, 2002-12, Vol.277 (52), p.50564-50572

2002

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Erosion of embolization coils into the renal collecting system mimicking stone

The western journal of emergency medicine, 2012-02, Vol.13 (1), p.127-130

2012

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Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation

Angewandte Chemie (International ed.), 2012-06, Vol.51 (25), p.6140-6143

International ed. in English, 2012

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Drugging an undruggable pocket on KRAS

Proceedings of the National Academy of Sciences - PNAS, 2019-08, Vol.116 (32), p.15823-15829

2019

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Fragment-Based Screening of the Bromodomain of ATAD2

Journal of medicinal chemistry, 2014-11, Vol.57 (22), p.9687-9692

2014

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Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC

Molecular cell, 2015-05, Vol.58 (3), p.440-452

2015

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Heterologous desensitization of cardiac β-adrenergic signal via hormone-induced βAR/arrestin/PDE4 complexes

Cardiovascular research, 2017-05, Vol.113 (6), p.656-670

2017

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Structure of Human Thymidylate Synthase Suggests Advantages of Chemotherapy with Noncompetitive Inhibitors

The Journal of biological chemistry, 2001-04, Vol.276 (17), p.14170-14177

2001

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Crystal structure of the Yersinia type III secretion protein YscE

Protein science, 2005-10, Vol.14 (10), p.2759-2763

2005

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High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling

Analytical biochemistry, 2018-05, Vol.548 (C), p.44-52

2018

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Discovery of WD Repeat-Containing Protein 5 (WDR5)–MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design

Journal of medicinal chemistry, 2020-04, Vol.63 (8), p.4315-4333

2020

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Foreign Talent, Local Glory: Can National Excellence Be Outsourced?

Sport, ethics and philosophy, 2013-05, Vol.7 (2), p.186-201

Phan, Jason

2013

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Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods

Journal of medicinal chemistry, 2020-08, Vol.63 (15), p.8325-8337

2020

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VOTING YOUR WAY INTO A SLUM: SINGAPORE'S ELECTION DILEMMA

Think : philosophy for everyone, 2014, Vol.13 (37), p.35-45

Phan, Jason

2014

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Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design

Journal of medicinal chemistry, 2018-07, Vol.61 (13), p.5623-5642

2018

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Discovery of Potent 2‑Aryl-6,7-dihydro‑5H‑pyrrolo[1,2‑a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design

Journal of medicinal chemistry, 2018-07, Vol.61 (13), p.5623-5642

2018

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Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRAS G12C Inhibitor

Journal of medicinal chemistry, 2022-11, Vol.65 (21), p.14614-14629

2022

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Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling

Journal of medicinal chemistry, 2018-07, Vol.61 (14), p.6002-6017

2018

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Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5–MYC Protein–Protein Interaction

Journal of medicinal chemistry, 2019-12, Vol.62 (24), p.11232-11259

2019

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Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange

Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRASG12C Inhibitor

Structure-based Design of High Affinity Peptides Inhibiting the Interaction of p53 with MDM2 and MDMX

Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS

Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity

Physical Therapy for Gait, Balance, and Cognition in Individuals with Cognitive Impairment: A Retrospective Analysis

Structural Basis for the Substrate Specificity of Tobacco Etch Virus Protease

Erosion of embolization coils into the renal collecting system mimicking stone

Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation

Drugging an undruggable pocket on KRAS

Fragment-Based Screening of the Bromodomain of ATAD2

Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC

Heterologous desensitization of cardiac β-adrenergic signal via hormone-induced βAR/arrestin/PDE4 complexes

Structure of Human Thymidylate Synthase Suggests Advantages of Chemotherapy with Noncompetitive Inhibitors

Crystal structure of the Yersinia type III secretion protein YscE

High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling

Discovery of WD Repeat-Containing Protein 5 (WDR5)–MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design

Foreign Talent, Local Glory: Can National Excellence Be Outsourced?

Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods

VOTING YOUR WAY INTO A SLUM: SINGAPORE'S ELECTION DILEMMA

Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design

Discovery of Potent 2‑Aryl-6,7-dihydro‑5H‑pyrrolo[1,2‑a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design

Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRAS G12C Inhibitor

Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling

Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5–MYC Protein–Protein Interaction

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