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Rabex-5 E3 and Rab5 GEF domains differ in their regulation of Ras, Notch, and PI3K signaling in Drosophila wing development

PloS one, 2024-10, Vol.19 (10), p.e0312274

2024

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A conserved, N-terminal tyrosine signal directs Ras for inhibition by Rabex-5

PLoS genetics, 2020-06, Vol.16 (6), p.e1008715

2020

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The Drosophila Mst Ortholog, hippo, Restricts Growth and Cell Proliferation and Promotes Apoptosis

Cell, 2003-08, Vol.114 (4), p.457-467

2003

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Mutation in E1, the ubiquitin activating enzyme, reduces Drosophila lifespan and results in motor impairment

PloS one, 2013-01, Vol.8 (1), p.e32835-e32835

2013

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The Hippo Pathway Targets Rae1 to Regulate Mitosis and Organ Size and to Feed Back to Regulate Upstream Components Merlin, Hippo, and Warts

PLoS genetics, 2016-08, Vol.12 (8), p.e1006198-e1006198

2016

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The Hippo Pathway: A Master Regulatory Network Important in Development and Dysregulated in Disease

Current topics in developmental biology, 2017, Vol.123, p.181-228

Pfleger, Cathie M

2017

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Rabex-5 Ubiquitin Ligase Activity Restricts Ras Signaling to Establish Pathway Homeostasis in Drosophila

Current biology, 2010-08, Vol.20 (15), p.1378-1382

2010

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Alcohol interacts with genetic alteration of the Hippo tumor suppressor pathway to modulate tissue growth in Drosophila

PloS one, 2013-10, Vol.8 (10), p.e78880

2013

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Mouse Ribonucleotide Reductase R2 Protein: A New Target for Anaphase-Promoting Complex-Cdh1-Mediated Proteolysis

Proceedings of the National Academy of Sciences - PNAS, 2003-04, Vol.100 (7), p.3925-3929

2003

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Lysines K117 and K147 play conserved roles in Ras activation from Drosophila to mammals

G3 : genes - genomes - genetics, 2023-11, Vol.13 (11)

2023

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MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network

Molecular cell, 2019-05, Vol.74 (3), p.452-465.e7

2019

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Drosophila Rabex-5 restricts Notch activity in hematopoietic cells and maintains hematopoietic homeostasis

Journal of cell science, 2015-12, Vol.128 (24), p.4512-4525

2015

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The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1

Genes & development, 2000-03, Vol.14 (6), p.655-665

2000

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Ubiquitin on ras: warden or partner in crime?

Science signaling, 2011-03, Vol.4 (163), p.pe12

Pfleger, Cathie M

2011

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Methods to Examine the Lymph Gland and Hemocytes in Drosophila Larvae

Journal of visualized experiments, 2016-11 (117)

2016

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Grape-Seed Polyphenolic Extract Improves the Eye Phenotype in a Drosophila Model of Tauopathy

International journal of alzheimer's disease, 2010, Vol.2010 (2010), p.1-5

2010

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Recent efforts to model human diseases in vivo in Drosophila

Fly, 2008-05, Vol.2 (3), p.129-132

2008

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Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1

Genes & development, 2001-07, Vol.15 (14), p.1759-1764

2001

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Impairment of ubiquitylation by mutation in Drosophila E1 promotes both cell-autonomous and non-cell-autonomous Ras-ERK activation in vivo

Journal of cell science, 2009-05, Vol.122 (9), p.1461-1470

2009

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Drosophila melanogaster Apaf-1 homologue ARK is required for most, but not all, programmed cell death

The Journal of cell biology, 2006-03, Vol.172 (6), p.809-815

2006

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The C-terminal Domain of the Xenopus Cyclin-dependent Kinase Inhibitor, p27Xic1, Is Both Necessary and Sufficient for Phosphorylation-independent Proteolysis

The Journal of biological chemistry, 2005-10, Vol.280 (42), p.35290-35298

2005

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Mutations in the Drosophila orthologs of the F-actin capping protein alpha- and beta-subunits cause actin accumulation and subsequent retinal degeneration

Genetics (Austin), 2005-12, Vol.171 (4), p.1757-1765

2005

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Potential application of grape derived polyphenols in Huntington’s disease

Translational neuroscience, 2010-06, Vol.1 (2), p.95-100

2010

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Mutation of the Gene Encoding the Ubiquitin Activating Enzyme Uba1 Causes Tissue Overgrowth in Drosophila

Fly (Austin, Tex.), 2007-03, Vol.1 (2), p.95-105

2007

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Methods to Examine the Lymph Gland and Hemocytes in Drosophila Larvae

Journal of visualized experiments, 2016-11 (117)

2016

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Rabex-5 E3 and Rab5 GEF domains differ in their regulation of Ras, Notch, and PI3K signaling in Drosophila wing development

A conserved, N-terminal tyrosine signal directs Ras for inhibition by Rabex-5

The Drosophila Mst Ortholog, hippo, Restricts Growth and Cell Proliferation and Promotes Apoptosis

Mutation in E1, the ubiquitin activating enzyme, reduces Drosophila lifespan and results in motor impairment

The Hippo Pathway Targets Rae1 to Regulate Mitosis and Organ Size and to Feed Back to Regulate Upstream Components Merlin, Hippo, and Warts

The Hippo Pathway: A Master Regulatory Network Important in Development and Dysregulated in Disease

Rabex-5 Ubiquitin Ligase Activity Restricts Ras Signaling to Establish Pathway Homeostasis in Drosophila

Alcohol interacts with genetic alteration of the Hippo tumor suppressor pathway to modulate tissue growth in Drosophila

Mouse Ribonucleotide Reductase R2 Protein: A New Target for Anaphase-Promoting Complex-Cdh1-Mediated Proteolysis

Lysines K117 and K147 play conserved roles in Ras activation from Drosophila to mammals

MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network

Drosophila Rabex-5 restricts Notch activity in hematopoietic cells and maintains hematopoietic homeostasis

The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1

Ubiquitin on ras: warden or partner in crime?

Methods to Examine the Lymph Gland and Hemocytes in Drosophila Larvae

Grape-Seed Polyphenolic Extract Improves the Eye Phenotype in a Drosophila Model of Tauopathy

Recent efforts to model human diseases in vivo in Drosophila

Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1

Impairment of ubiquitylation by mutation in Drosophila E1 promotes both cell-autonomous and non-cell-autonomous Ras-ERK activation in vivo

Drosophila melanogaster Apaf-1 homologue ARK is required for most, but not all, programmed cell death

The C-terminal Domain of the Xenopus Cyclin-dependent Kinase Inhibitor, p27Xic1, Is Both Necessary and Sufficient for Phosphorylation-independent Proteolysis

Mutations in the Drosophila orthologs of the F-actin capping protein alpha- and beta-subunits cause actin accumulation and subsequent retinal degeneration

Potential application of grape derived polyphenols in Huntington’s disease

Mutation of the Gene Encoding the Ubiquitin Activating Enzyme Uba1 Causes Tissue Overgrowth in Drosophila

Methods to Examine the Lymph Gland and Hemocytes in Drosophila Larvae

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