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Structural biology of the Bcl-2 family of proteins

BBA - Molecular Cell Research, 2004-03, Vol.1644 (2), p.83-94

2004

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Fragment-based discovery of potent inhibitors of the anti-apoptotic MCL-1 protein

Bioorganic & medicinal chemistry letters, 2014-03, Vol.24 (6), p.1484-1488

2014

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Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site

Scientific reports, 2022-08, Vol.12 (1), p.14561-14561, Article 14561

2022

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Discovery and Development of Potent and Selective Inhibitors of Histone Methyltransferase G9a

ACS medicinal chemistry letters, 2014-02, Vol.5 (2), p.205-209

2014

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Structure of the N-Terminal RNA-Binding Domain of the SARS CoV Nucleocapsid Protein

Biochemistry (Easton), 2004-05, Vol.43 (20), p.6059-6063

2004

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Solution Structure of the Antiapoptotic Protein bcl-2

Proceedings of the National Academy of Sciences - PNAS, 2001-03, Vol.98 (6), p.3012-3017

2001

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Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR

Bioorganic & medicinal chemistry letters, 2010-11, Vol.20 (22), p.6587-6591

2010

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Insights into the Conformation and Self-Association of a Concentrated Monoclonal Antibody using Isothermal Chemical Denaturation and Nuclear Magnetic Resonance

Journal of pharmaceutical sciences, 2021-12, Vol.110 (12), p.3819-3828

2021

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Defining the p53 DNA‐binding domain/Bcl‐xL‐binding interface using NMR

FEBS letters, 2004-02, Vol.559 (1-3), p.171-174

2004

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Structure-Guided Design of a Series of MCL‑1 Inhibitors with High Affinity and Selectivity

Journal of medicinal chemistry, 2015-03, Vol.58 (5), p.2180-2194

2015

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Efficiently driving protein-based fragment screening and lead discovery using two-dimensional NMR

Journal of biomolecular NMR, 2023-04, Vol.77 (1-2), p.39-53

2023

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Solution Structure of a Bcl-2 Homolog from Kaposi Sarcoma Virus

Proceedings of the National Academy of Sciences - PNAS, 2002-03, Vol.99 (6), p.3428-3433

2002

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NMR-based fragment screening and lead discovery accelerated by principal component analysis

Journal of biomolecular NMR, 2019-12, Vol.73 (12), p.675-685

2019

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A surface groove essential for viral Bcl-2 function during chronic infection in vivo

PLoS pathogens, 2005-09, Vol.1 (1), p.e10

2005

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Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design

Journal of medicinal chemistry, 2021-01, Vol.64 (1), p.417-429

2021

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Fragment-Based Discovery of an Apolipoprotein E4 (apoE4) Stabilizer

Journal of medicinal chemistry, 2019-04, Vol.62 (8), p.4120-4130

2019

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Structure and ligand recognition of the phosphotyrosine binding domain of Shc

Nature (London), 1995-12, Vol.378 (6557), p.584-592

1995

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Discovery of novel inhibitors of Bcl-xL using multiple high-throughput screening platforms

Analytical biochemistry, 2004-05, Vol.328 (2), p.131-138

2004

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Targeting lysine specific demethylase 4A (KDM4A) tandem TUDOR domain – A fragment based approach

Bioorganic & medicinal chemistry letters, 2018-06, Vol.28 (10), p.1708-1713

2018

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Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL

Journal of medicinal chemistry, 2007-02, Vol.50 (4), p.641-662

2007

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Fragment-based discovery of a potent NAMPT inhibitor

Bioorganic & medicinal chemistry letters, 2018-02, Vol.28 (3), p.437-440

2018

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Methylpyrrole inhibitors of BET bromodomains

Bioorganic & medicinal chemistry letters, 2017-05, Vol.27 (10), p.2225-2233

2017

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Solution structure of a pleckstrin-homology domain

Nature (London), 1994-06, Vol.369 (6482), p.672-675

1994

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Structural biology of the Bcl-2 family of proteins

Fragment-based discovery of potent inhibitors of the anti-apoptotic MCL-1 protein

Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site

Discovery and Development of Potent and Selective Inhibitors of Histone Methyltransferase G9a

Structure of the N-Terminal RNA-Binding Domain of the SARS CoV Nucleocapsid Protein

Solution Structure of the Antiapoptotic Protein bcl-2

Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR

Insights into the Conformation and Self-Association of a Concentrated Monoclonal Antibody using Isothermal Chemical Denaturation and Nuclear Magnetic Resonance

Defining the p53 DNA‐binding domain/Bcl‐xL‐binding interface using NMR

Structure-Guided Design of a Series of MCL‑1 Inhibitors with High Affinity and Selectivity

Efficiently driving protein-based fragment screening and lead discovery using two-dimensional NMR

Solution Structure of a Bcl-2 Homolog from Kaposi Sarcoma Virus

NMR-based fragment screening and lead discovery accelerated by principal component analysis

Discovery of a Potent and Selective BCL‑XL Inhibitor with in Vivo Activity

A surface groove essential for viral Bcl-2 function during chronic infection in vivo

Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors

Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design

Fragment-Based Discovery of an Apolipoprotein E4 (apoE4) Stabilizer

Structure and ligand recognition of the phosphotyrosine binding domain of Shc

Discovery of novel inhibitors of Bcl-xL using multiple high-throughput screening platforms

Targeting lysine specific demethylase 4A (KDM4A) tandem TUDOR domain – A fragment based approach

Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL

Fragment-based discovery of a potent NAMPT inhibitor

Methylpyrrole inhibitors of BET bromodomains

Solution structure of a pleckstrin-homology domain

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