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A Synthetic Antithrombin III Binding Pentasaccharide Is Now a Drug! What Comes Next?

Angewandte Chemie (International ed.), 2004-06, Vol.43 (24), p.3118-3133

2004

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Molecular modeling of the interaction between heparan sulfate and cellular growth factors: Bringing pieces together

Glycobiology (Oxford), 2011-09, Vol.21 (9), p.1181-1193

2011

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The Anticoagulant Activation of Antithrombin by Heparin

Proceedings of the National Academy of Sciences - PNAS, 1997-12, Vol.94 (26), p.14683-14688

1997

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Accelerating ability of synthetic oligosaccharides on antithrombin inhibition of proteinases of the clotting and fibrinolytic systems. Comparison with heparin and low-molecular-weight heparin

Thrombosis and haemostasis, 2004-11, Vol.92 (5), p.929-939

2004

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Heparan sulfate mimetics can efficiently mobilize long-term hematopoietic stem cells

Haematologica (Roma), 2012-04, Vol.97 (4), p.491-499

2012

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From heparin to EP217609: the long way to a new pentasaccharide-based neutralisable anticoagulant with an unprecedented pharmacological profile

Thrombosis and haemostasis, 2009-11, Vol.102 (5), p.804-810

2009

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Synthesis of thrombin-inhibiting heparin mimetics without side effects

Nature (London), 1999-04, Vol.398 (6726), p.417-422

1999

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Large, Tissue-regulated Domain Diversity of Heparan Sulfates Demonstrated by Phage Display Antibodies

The Journal of biological chemistry, 2002-03, Vol.277 (13), p.10982-10986

2002

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Rational design of anticoagulant drugs using oligosaccharide chemistry

Chimia, 2011-01, Vol.65 (1-2), p.14

2011

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Long-Lasting Enfuvirtide Carrier Pentasaccharide Conjugates with Potent Anti-Human Immunodeficiency Virus Type 1 Activity

Antimicrobial Agents and Chemotherapy, 2010-01, Vol.54 (1), p.134-142

2010

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The Unique Antithrombin III Binding Domain of Heparin: A Lead to New Synthetic Antithrombotics

Angewandte Chemie (International ed.), 1993-12, Vol.32 (12), p.1671-1690

1993

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Efficient selective deacetylation of complex oligosaccharides using the neutral organotin catalyst [tBu2SnOH(Cl)]2

Carbohydrate research, 2020-12, Vol.498, p.108172-108172, Article 108172

2020

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Degeneracy of the Antithrombin Binding Sequence in Heparin: 2‐O‐Sulfated Iduronic Acid Can Replace the Critical Glucuronic Acid

Chemistry : a European journal, 2020-09, Vol.26 (51), p.11814-11818

2020

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New Orally Active Non-Peptide Fibrinogen Receptor (GpIIb-IIIa) Antagonists: Identification of Ethyl 3-[N-[4-[4-[Amino[(ethoxycarbonyl)imino]methyl]phenyl]- 1,3-thiazol-2-yl]-N-[1-[(ethoxycarbonyl)methyl]piperid-4-yl]amino]propionate (SR 121787) as a Potent and Long-Acting Antithrombotic Agent

Journal of medicinal chemistry, 1997-10, Vol.40 (21), p.3393-3401

1997

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Specificity and selectivity profile of EP217609: a new neutralizable dual-action anticoagulant that targets thrombin and factor Xa

Blood, 2012-03, Vol.119 (10), p.2187-2195

2012

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Investigating Glycol-Split-Heparin-Derived Inhibitors of Heparanase: A Study of Synthetic Trisaccharides

Molecules (Basel, Switzerland), 2016-11, Vol.21 (11), p.1602-1602

2016

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Evidence for Multiple Binding Modes in the Initial Contact Between SARS‐CoV‐2 Spike S1 Protein and Cell Surface Glycans

Chemistry : a European journal, 2023-01, Vol.29 (1), p.e202202599-n/a

2023

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1976-1983, a critical period in the history of heparin: the discovery of the antithrombin binding site

Biochimie, 2003-01, Vol.85 (1-2), p.83-89

2003

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Mechanism of Heparin Activation of Antithrombin: Evidence for an Induced-Fit Model of Allosteric Activation Involving Two Interaction Subsites

Biochemistry (Easton), 1998-09, Vol.37 (37), p.13033-13041

1998

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Synthesis and Biological Evaluation of a Unique Heparin Mimetic Hexasaccharide for Structure–Activity Relationship Studies

Journal of medicinal chemistry, 2014-06, Vol.57 (11), p.4511-4520

2014

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The ternary complex of antithrombin-anhydrothrombin-heparin reveals the basis of inhibitor specificity

Nature structural & molecular biology, 2004-09, Vol.11 (9), p.863-867

2004

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A synthetic heparan sulfate pentasaccharide, exclusively containing L-iduronic acid, displays higher affinity for FGF-2 than its D-glucuronic acid-containing isomers

Bioorganic & medicinal chemistry, 1999-08, Vol.7 (8), p.1567-1580

1999

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Effect of fondaparinux on platelet activation in the presence of heparin-dependent antibodies: a blinded comparative multicenter study with unfractionated heparin

Blood, 2005-01, Vol.105 (1), p.139-144

2005

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Mechanism of Acceleration of Antithrombin-Proteinase Reactions by Low Affinity Heparin

The Journal of biological chemistry, 1995-04, Vol.270 (16), p.9043-9051

1995

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Chemoenzymatic Synthesis of D‐Glucaro‐δ‐lactam Containing Oligosaccharides as Putative Heparanase Inhibitors

ChemistrySelect (Weinheim), 2021-11, Vol.6 (42), p.11690-11695

2021

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A Synthetic Antithrombin III Binding Pentasaccharide Is Now a Drug! What Comes Next?

Molecular modeling of the interaction between heparan sulfate and cellular growth factors: Bringing pieces together

The Anticoagulant Activation of Antithrombin by Heparin

Accelerating ability of synthetic oligosaccharides on antithrombin inhibition of proteinases of the clotting and fibrinolytic systems. Comparison with heparin and low-molecular-weight heparin

Heparan sulfate mimetics can efficiently mobilize long-term hematopoietic stem cells

From heparin to EP217609: the long way to a new pentasaccharide-based neutralisable anticoagulant with an unprecedented pharmacological profile

Synthesis of thrombin-inhibiting heparin mimetics without side effects

Large, Tissue-regulated Domain Diversity of Heparan Sulfates Demonstrated by Phage Display Antibodies

Rational design of anticoagulant drugs using oligosaccharide chemistry

Long-Lasting Enfuvirtide Carrier Pentasaccharide Conjugates with Potent Anti-Human Immunodeficiency Virus Type 1 Activity

The Unique Antithrombin III Binding Domain of Heparin: A Lead to New Synthetic Antithrombotics

Efficient selective deacetylation of complex oligosaccharides using the neutral organotin catalyst [tBu2SnOH(Cl)]2

Degeneracy of the Antithrombin Binding Sequence in Heparin: 2‐O‐Sulfated Iduronic Acid Can Replace the Critical Glucuronic Acid

New Orally Active Non-Peptide Fibrinogen Receptor (GpIIb-IIIa) Antagonists: Identification of Ethyl 3-[N-[4-[4-[Amino[(ethoxycarbonyl)imino]methyl]phenyl]- 1,3-thiazol-2-yl]-N-[1-[(ethoxycarbonyl)methyl]piperid-4-yl]amino]propionate (SR 121787) as a Potent and Long-Acting Antithrombotic Agent

Specificity and selectivity profile of EP217609: a new neutralizable dual-action anticoagulant that targets thrombin and factor Xa

Investigating Glycol-Split-Heparin-Derived Inhibitors of Heparanase: A Study of Synthetic Trisaccharides

Evidence for Multiple Binding Modes in the Initial Contact Between SARS‐CoV‐2 Spike S1 Protein and Cell Surface Glycans

1976-1983, a critical period in the history of heparin: the discovery of the antithrombin binding site

Mechanism of Heparin Activation of Antithrombin: Evidence for an Induced-Fit Model of Allosteric Activation Involving Two Interaction Subsites

Synthesis and Biological Evaluation of a Unique Heparin Mimetic Hexasaccharide for Structure–Activity Relationship Studies

The ternary complex of antithrombin-anhydrothrombin-heparin reveals the basis of inhibitor specificity

A synthetic heparan sulfate pentasaccharide, exclusively containing L-iduronic acid, displays higher affinity for FGF-2 than its D-glucuronic acid-containing isomers

Effect of fondaparinux on platelet activation in the presence of heparin-dependent antibodies: a blinded comparative multicenter study with unfractionated heparin

Mechanism of Acceleration of Antithrombin-Proteinase Reactions by Low Affinity Heparin

Chemoenzymatic Synthesis of D‐Glucaro‐δ‐lactam Containing Oligosaccharides as Putative Heparanase Inhibitors

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