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Population pharmacokinetic/pharmacodynamic modeling for remimazolam in the induction and maintenance of general anesthesia in healthy subjects and in surgical subjects

Journal of clinical anesthesia, 2020-11, Vol.66, p.109899, Article 109899

2020

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Constipation in older people: A consensus statement

International journal of clinical practice (Esher), 2017-01, Vol.71 (1), p.e12920-n/a

2017

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Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity

Nature medicine, 2012-07, Vol.18 (7), p.1123-1129

2012

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Metabolism of remimazolam in primary human hepatocytes during continuous long-term infusion in a 3-D bioreactor system

Drug design, development and therapy, 2019-04, Vol.13, p.1033-1047

2019

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Tissue-type plasminogen activator controls neuronal death by raising surface dynamics of extrasynaptic NMDA receptors

Cell death & disease, 2016-11, Vol.7 (11), p.e2466-e2466

2016

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Recombinant Thrombomodulin (Solulin) Ameliorates Early Intestinal Radiation Toxicity in a Preclinical Rat Model

Radiation research, 2016-08, Vol.186 (2), p.112-120

2016

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Comment on: “Differences in In Vitro Properties of Pancreatin Preparations for Pancreatic Exocrine Insufficiency as Marketed in Russia and CIS”

Drugs in R&D, 2021-12, Vol.21 (4), p.467-468

Petersen, Karl-Uwe

2021

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A miniature pig model of pharmacological tolerance to long-term sedation with the intravenous benzodiazepines; midazolam and remimazolam

European journal of pharmacology, 2021-04, Vol.896, p.173886-173886, Article 173886

2021

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Pepsin and Its Importance for Functional Dyspepsia: Relic, Regulator or Remedy?

Digestive diseases (Basel), 2018-01, Vol.36 (2), p.98-105

Petersen, Karl-Uwe

2018

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The Metabolism of the New Benzodiazepine Remimazolam

Current drug metabolism, 2024-01, Vol.25 (2), p.164-173

2024

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The case of drug causation of childhood asthma: antibiotics and paracetamol

European journal of clinical pharmacology, 2013-06, Vol.69 (6), p.1197-1209

2013

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Impact of concurrent remifentanil on the sedative effects of remimazolam, midazolam and propofol in cynomolgus monkeys

European journal of pharmacology, 2021-01, Vol.890, p.173639, Article 173639

2021

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Solulin reduces infarct volume and regulates gene-expression in transient middle cerebral artery occlusion in rats

BMC neuroscience, 2011-11, Vol.12 (1), p.113-113, Article 113

2011

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Time‐to‐Event Modeling for Remimazolam for the Indication of Induction and Maintenance of General Anesthesia

Journal of clinical pharmacology, 2020-04, Vol.60 (4), p.505-514

2020

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Vampire bat salivary plasminogen activator (desmoteplase) inhibits tissue-type plasminogen activator-induced potentiation of excitotoxic injury

Stroke (1970), 2005-06, Vol.36 (6), p.1241-1246

2005

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Solulin increases clot stability in whole blood from humans and dogs with hemophilia

Blood, 2012-04, Vol.119 (15), p.3622-3628

2012

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Immunotherapy blocking the tissue plasminogen activator-dependent activation of N-methyl-d-aspartate glutamate receptors improves hemorrhagic stroke outcome

Neuropharmacology, 2013-04, Vol.67, p.267-271

2013

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Decreasing the infusion rate reduces the proarrhythmic risk of NS‐7: confirming the relevance of short‐term variability of repolarisation in predicting drug‐induced torsades de pointes

British journal of pharmacology, 2005-06, Vol.145 (3), p.397-404

2005

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Thrombin-induced activation of astrocytes in mixed rat hippocampal cultures is inhibited by soluble thrombomodulin

Brain research, 2011-03, Vol.1381, p.38-51

2011

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Antibodies Preventing the Interaction of Tissue-Type Plasminogen Activator With N-Methyl-D-Aspartate Receptors Reduce Stroke Damages and Extend the Therapeutic Window of Thrombolysis

Stroke (1970), 2011-08, Vol.42 (8), p.2315-2322

2011

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Toward safer thrombolytic agents in stroke: molecular requirements for NMDA receptor-mediated neurotoxicity

Journal of cerebral blood flow and metabolism, 2008-06, Vol.28 (6), p.1212-1221

2008

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Thrombomodulin and the brain: past, present, and future

Neurology, 2012-04, Vol.78 (16), p.1280-1281

2012

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Recombinant Desmodus rotundus salivary plasminogen activator crosses the blood-brain barrier through a low-density lipoprotein receptor-related protein-dependent mechanism without exerting neurotoxic effects

Stroke (1970), 2007-03, Vol.38 (3), p.1036-1043

2007

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(3) -2 Pre-clinical profile of Remimazolam

The Journal of Japan Society for Clinical Anesthesia, 2017-10, Vol.37 (6), p.S202-S202

Karl-Uwe Petersen

2017

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PPACK-Desmodus rotundus salivary plasminogen activator (cDSPAalpha1) prevents the passage of tissue-type plasminogen activator (rt-PA) across the blood-brain barrier and neurotoxicity

Thrombosis and haemostasis, 2009-09, Vol.102 (3), p.606

2009

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Population pharmacokinetic/pharmacodynamic modeling for remimazolam in the induction and maintenance of general anesthesia in healthy subjects and in surgical subjects

Constipation in older people: A consensus statement

Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity

Metabolism of remimazolam in primary human hepatocytes during continuous long-term infusion in a 3-D bioreactor system

Tissue-type plasminogen activator controls neuronal death by raising surface dynamics of extrasynaptic NMDA receptors

Recombinant Thrombomodulin (Solulin) Ameliorates Early Intestinal Radiation Toxicity in a Preclinical Rat Model

Comment on: “Differences in In Vitro Properties of Pancreatin Preparations for Pancreatic Exocrine Insufficiency as Marketed in Russia and CIS”

A miniature pig model of pharmacological tolerance to long-term sedation with the intravenous benzodiazepines; midazolam and remimazolam

Pepsin and Its Importance for Functional Dyspepsia: Relic, Regulator or Remedy?

The Metabolism of the New Benzodiazepine Remimazolam

The case of drug causation of childhood asthma: antibiotics and paracetamol

Impact of concurrent remifentanil on the sedative effects of remimazolam, midazolam and propofol in cynomolgus monkeys

Solulin reduces infarct volume and regulates gene-expression in transient middle cerebral artery occlusion in rats

Time‐to‐Event Modeling for Remimazolam for the Indication of Induction and Maintenance of General Anesthesia

Vampire bat salivary plasminogen activator (desmoteplase) inhibits tissue-type plasminogen activator-induced potentiation of excitotoxic injury

Solulin increases clot stability in whole blood from humans and dogs with hemophilia

Immunotherapy blocking the tissue plasminogen activator-dependent activation of N-methyl-d-aspartate glutamate receptors improves hemorrhagic stroke outcome

Decreasing the infusion rate reduces the proarrhythmic risk of NS‐7: confirming the relevance of short‐term variability of repolarisation in predicting drug‐induced torsades de pointes

Thrombin-induced activation of astrocytes in mixed rat hippocampal cultures is inhibited by soluble thrombomodulin

Antibodies Preventing the Interaction of Tissue-Type Plasminogen Activator With N-Methyl-D-Aspartate Receptors Reduce Stroke Damages and Extend the Therapeutic Window of Thrombolysis

Toward safer thrombolytic agents in stroke: molecular requirements for NMDA receptor-mediated neurotoxicity

Thrombomodulin and the brain: past, present, and future

Recombinant Desmodus rotundus salivary plasminogen activator crosses the blood-brain barrier through a low-density lipoprotein receptor-related protein-dependent mechanism without exerting neurotoxic effects

(3) -2 Pre-clinical profile of Remimazolam

PPACK-Desmodus rotundus salivary plasminogen activator (cDSPAalpha1) prevents the passage of tissue-type plasminogen activator (rt-PA) across the blood-brain barrier and neurotoxicity

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