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Role of mitochondria in non-alcoholic fatty liver disease

Journal of gastroenterology and hepatology, 2007-06, Vol.22 (s1), p.S20-S27

Pessayre, Dominique

2007

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Drug-induced liver injury through mitochondrial dysfunction: mechanisms and detection during preclinical safety studies

Fundamental & clinical pharmacology, 2008-08, Vol.22 (4), p.335-353

2008

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Central role of mitochondria in drug-induced liver injury

Drug metabolism reviews, 2012-02, Vol.44 (1), p.34-87

2012

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Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity

The Journal of pharmacology and experimental therapeutics, 2005-11, Vol.315 (2), p.879

2005

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NOX family NADPH oxidases in liver and in pancreatic islets: a role in the metabolic syndrome and diabetes?

Biochemical Society transactions, 2008-10, Vol.36 (Pt 5), p.920

2008

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Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: a model of viral‐related steatosis

The FASEB journal, 2002-02, Vol.16 (2), p.185-194

2002

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Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity

Pharmacology & therapeutics (Oxford), 1995, Vol.67 (1), p.101-154

1995

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Hepatic mitochondrial DNA depletion after an alcohol binge in mice: probable role of peroxynitrite and modulation by manganese superoxide dismutase

The Journal of pharmacology and experimental therapeutics, 2010-03, Vol.332 (3), p.886

2010

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Tamoxifen inhibits topoisomerases, depletes mitochondrial DNA, and triggers steatosis in mouse liver

The Journal of pharmacology and experimental therapeutics, 2007-05, Vol.321 (2), p.526

2007

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Acute ethanol administration oxidatively damages and depletes mitochondrial dna in mouse liver, brain, heart, and skeletal muscles: protective effects of antioxidants

The Journal of pharmacology and experimental therapeutics, 2001-08, Vol.298 (2), p.737

2001

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Impaired mitochondrial function in microvesicular steatosis effects of drugs, ethanol, hormones and cytokines

Journal of hepatology, 1997, Vol.26, p.43-53

1997

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Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes

Gastroenterology (New York, N.Y. 1943), 1998-04, Vol.114 (4), p.764-774

1998

Volltextzugriff (PDF)

NASH : a mitochondrial disease

Journal of hepatology, 2005-06, Vol.42 (6), p.928-940

2005

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Partial leptin deficiency favors diet-induced obesity and related metabolic disorders in mice

American journal of physiology: endocrinology and metabolism, 2008-05, Vol.294 (5), p.E939-E951

2008

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Microvesicular steatosis and steatohepatitis: role of mitochondrial dysfunction and lipid peroxidation

Journal of hepatology, 1997, Vol.26, p.13-22

1997

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The anti-inflammatory drug, nimesulide (4-nitro-2-phenoxymethane-sulfoanilide), uncouples mitochondria and induces mitochondrial permeability transition in human hepatoma cells: protection by albumin

The Journal of pharmacology and experimental therapeutics, 2006-07, Vol.318 (1), p.444

2006

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Acute and chronic hepatic steatosis lead to in vivo lipid peroxidation in mice

Journal of hepatology, 1996-02, Vol.24 (2), p.200-208

1996

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Protein kinase PKC delta and c-Abl are required for mitochondrial apoptosis induction by genotoxic stress in the absence of p53, p73 and Fas receptor

FEBS letters, 2006-05, Vol.580 (11), p.2547-2552

2006

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Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it

Mitochondrion, 2006-02, Vol.6 (1), p.1-28

2006

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Opening of the mitochondrial permeability transition pore causes matrix expansion and outer membrane rupture in fas‐mediated hepatic apoptosis in mice

Hepatology (Baltimore, Md.), 2000-03, Vol.31 (3), p.674-683

2000

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Toxicity of alpidem, a peripheral benzodiazepine receptor ligand, but not zolpidem, in rat hepatocytes: role of mitochondrial permeability transition and metabolic activation

The Journal of pharmacology and experimental therapeutics, 2001-11, Vol.299 (2), p.793

2001

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Cytochrome P450–generated reactive metabolites cause mitochondrial permeability transition, caspase activation, and apoptosis in rat hepatocytes

Hepatology (Baltimore, Md.), 2000-08, Vol.32 (2), p.303-311

2000

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Human Microsomal Epoxide Hydrolase Is the Target of Germander-Induced Autoantibodies on the Surface of Human Hepatocytes

Molecular pharmacology, 2000-09, Vol.58 (3), p.542-551

2000

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Mitochondrial involvement in drug-induced liver injury

Handbook of experimental pharmacology, 2010 (196), p.311

2010

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Mitochondrial and Metabolic Effects of Nucleoside Reverse Transcriptase Inhibitors (NRTIs) in Mice Receiving One of Five Single- and Three Dual-NRTI Treatments

Antimicrobial Agents and Chemotherapy, 2003-11, Vol.47 (11), p.3384-3392

2003

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Role of mitochondria in non-alcoholic fatty liver disease

Drug-induced liver injury through mitochondrial dysfunction: mechanisms and detection during preclinical safety studies

Central role of mitochondria in drug-induced liver injury

Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity

NOX family NADPH oxidases in liver and in pancreatic islets: a role in the metabolic syndrome and diabetes?

Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: a model of viral‐related steatosis

Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity

Hepatic mitochondrial DNA depletion after an alcohol binge in mice: probable role of peroxynitrite and modulation by manganese superoxide dismutase

Tamoxifen inhibits topoisomerases, depletes mitochondrial DNA, and triggers steatosis in mouse liver

Acute ethanol administration oxidatively damages and depletes mitochondrial dna in mouse liver, brain, heart, and skeletal muscles: protective effects of antioxidants

Impaired mitochondrial function in microvesicular steatosis effects of drugs, ethanol, hormones and cytokines

Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes

NASH : a mitochondrial disease

Partial leptin deficiency favors diet-induced obesity and related metabolic disorders in mice

Microvesicular steatosis and steatohepatitis: role of mitochondrial dysfunction and lipid peroxidation

The anti-inflammatory drug, nimesulide (4-nitro-2-phenoxymethane-sulfoanilide), uncouples mitochondria and induces mitochondrial permeability transition in human hepatoma cells: protection by albumin

Acute and chronic hepatic steatosis lead to in vivo lipid peroxidation in mice

Protein kinase PKC delta and c-Abl are required for mitochondrial apoptosis induction by genotoxic stress in the absence of p53, p73 and Fas receptor

Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it

Opening of the mitochondrial permeability transition pore causes matrix expansion and outer membrane rupture in fas‐mediated hepatic apoptosis in mice

Toxicity of alpidem, a peripheral benzodiazepine receptor ligand, but not zolpidem, in rat hepatocytes: role of mitochondrial permeability transition and metabolic activation

Cytochrome P450–generated reactive metabolites cause mitochondrial permeability transition, caspase activation, and apoptosis in rat hepatocytes

Human Microsomal Epoxide Hydrolase Is the Target of Germander-Induced Autoantibodies on the Surface of Human Hepatocytes

Mitochondrial involvement in drug-induced liver injury

Mitochondrial and Metabolic Effects of Nucleoside Reverse Transcriptase Inhibitors (NRTIs) in Mice Receiving One of Five Single- and Three Dual-NRTI Treatments

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