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Mathematical modeling of endogenous and exogenously administered T cell recirculation in mouse and its application to pharmacokinetic studies of cell therapies

Frontiers in immunology, 2024-04, Vol.15, p.1357706

2024

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An integrative mechanistic model of thymocyte dynamics

Frontiers in immunology, 2024-02, Vol.15, p.1321309-1321309

2024

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Interpretation of metabolic memory phenomenon using a physiological systems model: What drives oxidative stress following glucose normalization?

PloS one, 2017-02, Vol.12 (2), p.e0171781-e0171781

2017

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Mathematical modeling in autoimmune diseases: from theory to clinical application

Frontiers in immunology, 2024-03, Vol.15, p.1371620

2024

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Role of T Cell-To-Dendritic Cell Chemoattraction in T Cell Priming Initiation in the Lymph Node: An Agent-Based Modeling Study

Frontiers in immunology, 2019-06, Vol.10, p.1289-1289

2019

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Quantitative Mechanistic Modeling in Support of Pharmacological Therapeutics Development in Immuno-Oncology

Frontiers in immunology, 2019-04, Vol.10, p.924-924

2019

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Assessment of NSCLC disease burden: A survival model-based meta-analysis study

Computational and structural biotechnology journal, 2024-12, Vol.24, p.611-621

2024

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Combination of immune checkpoint inhibitors with radiation therapy in cancer: A hammer breaking the wall of resistance

Frontiers in oncology, 2022-12, Vol.12, p.1035884-1035884

2022

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Comparative quantitative systems pharmacology modeling of anti-PCSK9 therapeutic modalities in hypercholesterolemia[S]

Journal of lipid research, 2019-09, Vol.60 (9), p.1610-1621

2019

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Agent Based Modeling of Human Gut Microbiome Interactions and Perturbations

PloS one, 2016-02, Vol.11 (2), p.e0148386

2016

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Elaborating on anti CTLA-4 mechanisms of action using an agent-based modeling approach

Frontiers in applied mathematics and statistics, 2022-10, Vol.8

2022

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Quantification of Scheduling Impact on Safety and Efficacy Outcomes of Brain Metastasis Radio- and Immuno-Therapies: A Systematic Review and Meta-Analysis

Frontiers in oncology, 2020-09, Vol.10, p.1609

2020

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Cycle Network Model of Prostaglandin H Synthase-1

Pharmaceuticals (Basel, Switzerland), 2020-09, Vol.13 (10), p.265

2020

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A workflow for the joint modeling of longitudinal and event data in the development of therapeutics: Tools, statistical methods, and diagnostics

CPT: pharmacometrics and systems pharmacology, 2022-04, Vol.11 (4), p.425-437

2022

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A tutorial for model‐based evaluation and translation of cardiovascular safety in preclinical trials

CPT: pharmacometrics and systems pharmacology, 2024-01, Vol.13 (1), p.5-22

2024

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Optimization of the MACE endpoint composition to increase power in studies of lipid-lowering therapies-a model-based meta-analysis

Frontiers in cardiovascular medicine, 2024-01, Vol.10, p.1242845-1242845

2024

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Radiation and PD-(L)1 treatment combinations: immune response and dose optimization via a predictive systems model

Journal for immunotherapy of cancer, 2018-02, Vol.6 (1), p.17-15, Article 17

2018

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Semi-Mechanistic Pharmacokinetic-Pharmacodynamic Model of Camostat Mesylate-Predicted Efficacy against SARS-CoV-2 in COVID-19

Microbiology spectrum, 2022-04, Vol.10 (2), p.e0216721

2022

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Evaluation of therapeutic strategies targeting BCAA catabolism using a systems pharmacology model

Frontiers in pharmacology, 2022-11, Vol.13, p.993422-993422

2022

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Dose dependence of treatment-related adverse events for immune checkpoint inhibitor therapies: a model-based meta-analysis

Oncoimmunology, 2020-01, Vol.9 (1), p.1748982

2020

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Evaluation of Combination Strategies for the A2AR Inhibitor AZD4635 Across Tumor Microenvironment Conditions via a Systems Pharmacology Model

Frontiers in immunology, 2021-03, Vol.12, p.617316-617316

2021

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Differentiating the Sodium‐Glucose Cotransporter 1 Inhibition Capacity of Canagliflozin vs. Dapagliflozin and Empagliflozin Using Quantitative Systems Pharmacology Modeling

CPT: pharmacometrics and systems pharmacology, 2020-04, Vol.9 (4), p.222-229

2020

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Quantitative Systems Pharmacology: An Exemplar Model‐Building Workflow With Applications in Cardiovascular, Metabolic, and Oncology Drug Development

CPT: pharmacometrics and systems pharmacology, 2019-06, Vol.8 (6), p.380-395

2019

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Applications of Model-Based Meta-Analysis in Drug Development

Pharmaceutical research, 2022-08, Vol.39 (8), p.1761-1777

2022

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DBSolve Optimum: a software package for kinetic modeling which allows dynamic visualization of simulation results

BMC systems biology, 2010-08, Vol.4 (1), p.109-109, Article 109

2010

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Mathematical modeling of endogenous and exogenously administered T cell recirculation in mouse and its application to pharmacokinetic studies of cell therapies

An integrative mechanistic model of thymocyte dynamics

Interpretation of metabolic memory phenomenon using a physiological systems model: What drives oxidative stress following glucose normalization?

Mathematical modeling in autoimmune diseases: from theory to clinical application

Role of T Cell-To-Dendritic Cell Chemoattraction in T Cell Priming Initiation in the Lymph Node: An Agent-Based Modeling Study

Quantitative Mechanistic Modeling in Support of Pharmacological Therapeutics Development in Immuno-Oncology

Assessment of NSCLC disease burden: A survival model-based meta-analysis study

Combination of immune checkpoint inhibitors with radiation therapy in cancer: A hammer breaking the wall of resistance

Comparative quantitative systems pharmacology modeling of anti-PCSK9 therapeutic modalities in hypercholesterolemia[S]

Agent Based Modeling of Human Gut Microbiome Interactions and Perturbations

Elaborating on anti CTLA-4 mechanisms of action using an agent-based modeling approach

Quantification of Scheduling Impact on Safety and Efficacy Outcomes of Brain Metastasis Radio- and Immuno-Therapies: A Systematic Review and Meta-Analysis

Cycle Network Model of Prostaglandin H Synthase-1

A workflow for the joint modeling of longitudinal and event data in the development of therapeutics: Tools, statistical methods, and diagnostics

A tutorial for model‐based evaluation and translation of cardiovascular safety in preclinical trials

Optimization of the MACE endpoint composition to increase power in studies of lipid-lowering therapies-a model-based meta-analysis

Radiation and PD-(L)1 treatment combinations: immune response and dose optimization via a predictive systems model

Semi-Mechanistic Pharmacokinetic-Pharmacodynamic Model of Camostat Mesylate-Predicted Efficacy against SARS-CoV-2 in COVID-19

Evaluation of therapeutic strategies targeting BCAA catabolism using a systems pharmacology model

Dose dependence of treatment-related adverse events for immune checkpoint inhibitor therapies: a model-based meta-analysis

Evaluation of Combination Strategies for the A2AR Inhibitor AZD4635 Across Tumor Microenvironment Conditions via a Systems Pharmacology Model

Differentiating the Sodium‐Glucose Cotransporter 1 Inhibition Capacity of Canagliflozin vs. Dapagliflozin and Empagliflozin Using Quantitative Systems Pharmacology Modeling

Quantitative Systems Pharmacology: An Exemplar Model‐Building Workflow With Applications in Cardiovascular, Metabolic, and Oncology Drug Development

Applications of Model-Based Meta-Analysis in Drug Development

DBSolve Optimum: a software package for kinetic modeling which allows dynamic visualization of simulation results

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