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Targeting the endocannabinoid system with cannabinoid receptor agonists: pharmacological strategies and therapeutic possibilities

Philosophical transactions of the Royal Society of London. Series B. Biological sciences, 2012-12, Vol.367 (1607), p.3353-3363

Pertwee, Roger G

2012

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Emerging strategies for exploiting cannabinoid receptor agonists as medicines

British journal of pharmacology, 2009-02, Vol.156 (3), p.397-411

Pertwee, Roger G

2009

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Endocannabinoids and Their Pharmacological Actions

Handbook of experimental pharmacology, 2015, Vol.231, p.1

Pertwee, Roger G

2015

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Elevating endocannabinoid levels: pharmacological strategies and potential therapeutic applications

Proceedings of the Nutrition Society, 2014-02, Vol.73 (1), p.96-105

Pertwee, Roger G.

2014

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Are cannabidiol and Δ(9) -tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review

British journal of pharmacology, 2015-02, Vol.172 (3), p.737-753

2015

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Cannabinoid pharmacology: the first 66 years

British journal of pharmacology, 2006-01, Vol.147 (S1), p.S163-S171

Pertwee, Roger G

2006

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Endocannabinoids

1, 2015

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Ligands that target cannabinoid receptors in the brain: from THC to anandamide and beyond

Addiction biology, 2008-06, Vol.13 (2), p.147-159

Pertwee, Roger G.

2008

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The 90th Birthday of Professor Raphael Mechoulam, a Top Cannabinoid Scientist and Pioneer

International journal of molecular sciences, 2020-10, Vol.21 (20), p.7653

Pertwee, Roger G.

2020

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Inverse agonism and neutral antagonism at cannabinoid CB1 receptors

Life sciences (1973), 2005-02, Vol.76 (12), p.1307-1324

Pertwee, Roger G

2005

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Positive Allosteric Modulation of Cannabinoid Receptor Type 1 Suppresses Pathological Pain Without Producing Tolerance or Dependence

Biological psychiatry (1969), 2018-11, Vol.84 (10), p.722-733

2018

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The Plant Derived 3-3′-Diindolylmethane (DIM) Behaves as CB2 Receptor Agonist in Prostate Cancer Cellular Models

International journal of molecular sciences, 2023-02, Vol.24 (4), p.3620

2023

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Effect of cannabis on glutamate signalling in the brain: A systematic review of human and animal evidence

Neuroscience and biobehavioral reviews, 2016-05, Vol.64, p.359-381

2016

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M3 Receptor Pathway Stimulates Rapid Transcription of the CB1 Receptor Activation through Calcium Signalling and the CNR1 Gene Promoter

International journal of molecular sciences, 2023-01, Vol.24 (2), p.1308

2023

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Phytocannabinoids beyond the Cannabis plant – do they exist?

British journal of pharmacology, 2010-06, Vol.160 (3), p.523-529

2010

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The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids

The AAPS journal, 2005-10, Vol.7 (3), p.E625-E654

Pertwee, Roger G

2005

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Identification of the First Synthetic Allosteric Modulator of the CB 2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief

Journal of medicinal chemistry, 2019-01, Vol.62 (1), p.276-287

2019

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Identification of the First Synthetic Allosteric Modulator of the CB2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief

Journal of medicinal chemistry, 2019-01, Vol.62 (1), p.276-287

2019

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Cannabidiol Targets Mitochondria to Regulate Intracellular Ca2+ Levels

The Journal of neuroscience, 2009-02, Vol.29 (7), p.2053-2063

2009

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Lipoxin A₄ is an allosteric endocannabinoid that strengthens anandamide-induced CB₁ receptor activation

Proceedings of the National Academy of Sciences - PNAS, 2012-12, Vol.109 (51), p.20781-20782

Pertwee, Roger G.

2012

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Cannabidiolic acid methyl ester, a stable synthetic analogue of cannabidiolic acid, can produce 5‐HT1A receptor‐mediated suppression of nausea and anxiety in rats

British journal of pharmacology, 2018-01, Vol.175 (1), p.100-112

2018

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Increasing levels of the endocannabinoid 2-AG is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

Experimental neurology, 2015-11, Vol.273, p.36-44

2015

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Pharmacology and potential therapeutic uses of some cannabinoids

Future neurology, 2019-11, Vol.14 (4)

Pertwee, Roger G

2019

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CB2 cannabinoid receptor agonist enantiomers HU-433 and HU-308: An inverse relationship between binding affinity and biological potency

Proceedings of the National Academy of Sciences - PNAS, 2015-07, Vol.112 (28), p.8774-8779

2015

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Anticancer effects of n-3 EPA and DHA and their endocannabinoid derivatives on breast cancer cell growth and invasion

Prostaglandins, leukotrienes and essential fatty acids, 2020-05, Vol.156, p.102024-102024, Article 102024

2020

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Targeting the endocannabinoid system with cannabinoid receptor agonists: pharmacological strategies and therapeutic possibilities

Emerging strategies for exploiting cannabinoid receptor agonists as medicines

Endocannabinoids and Their Pharmacological Actions

Elevating endocannabinoid levels: pharmacological strategies and potential therapeutic applications

Are cannabidiol and Δ(9) -tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review

Cannabinoid pharmacology: the first 66 years

Endocannabinoids

Ligands that target cannabinoid receptors in the brain: from THC to anandamide and beyond

The 90th Birthday of Professor Raphael Mechoulam, a Top Cannabinoid Scientist and Pioneer

Inverse agonism and neutral antagonism at cannabinoid CB1 receptors

Positive Allosteric Modulation of Cannabinoid Receptor Type 1 Suppresses Pathological Pain Without Producing Tolerance or Dependence

The Plant Derived 3-3′-Diindolylmethane (DIM) Behaves as CB2 Receptor Agonist in Prostate Cancer Cellular Models

Effect of cannabis on glutamate signalling in the brain: A systematic review of human and animal evidence

M3 Receptor Pathway Stimulates Rapid Transcription of the CB1 Receptor Activation through Calcium Signalling and the CNR1 Gene Promoter

Phytocannabinoids beyond the Cannabis plant – do they exist?

The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids

Identification of the First Synthetic Allosteric Modulator of the CB 2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief

Identification of the First Synthetic Allosteric Modulator of the CB2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief

Cannabidiol Targets Mitochondria to Regulate Intracellular Ca2+ Levels

Lipoxin A₄ is an allosteric endocannabinoid that strengthens anandamide-induced CB₁ receptor activation

Cannabidiolic acid methyl ester, a stable synthetic analogue of cannabidiolic acid, can produce 5‐HT1A receptor‐mediated suppression of nausea and anxiety in rats

Increasing levels of the endocannabinoid 2-AG is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

Pharmacology and potential therapeutic uses of some cannabinoids

CB2 cannabinoid receptor agonist enantiomers HU-433 and HU-308: An inverse relationship between binding affinity and biological potency

Anticancer effects of n-3 EPA and DHA and their endocannabinoid derivatives on breast cancer cell growth and invasion

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