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A phase 1/2 trial of HQK-1001, an oral fetal globin inducer, in sickle cell disease

American journal of hematology, 2012-11, Vol.87 (11), p.1017-1021

2012

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Sustained Induction of Fetal Hemoglobin by Pulse Butyrate Therapy in Sickle Cell Disease

Blood, 1999-03, Vol.93 (6), p.1790-1797

1999

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Isobutyramide, an orally bioavailable butyrate analogue, stimulates fetal globin gene expression in vitro and in vivo

British journal of haematology, 1994-11, Vol.88 (3), p.555-561

1994

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Short-chain fatty acid derivatives induce fetal globin expression and erythropoiesis in vivo

Blood, 2002-12, Vol.100 (13), p.4640-4648

2002

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Sickle cell anemia is associated with reduced nitric oxide bioactivity in peripheral conduit and resistance vessels

American journal of hematology, 2003-10, Vol.74 (2), p.104-111

2003

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A Short-Term Trial of Butyrate to Stimulate Fetal-Globin-Gene Expression in the β-Globin Disorders

The New England journal of medicine, 1993-01, Vol.328 (2), p.81-86

1993

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Induction of the Epstein–Barr virus thymidine kinase gene with concomitant nucleoside antivirals as a therapeutic strategy for Epstein–Barr virus–associated malignancies

Current opinion in oncology, 2001-09, Vol.13 (5), p.360-367

2001

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Induction of Fetal Globin in β-Thalassemia: Cellular Obstacles and Molecular Progress

Annals of the New York Academy of Sciences, 2005-01, Vol.1054 (1), p.257-265

2005

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Short-chain fatty acid derivatives stimulate cell proliferation and induce STAT-5 activation

Blood, 2001-05, Vol.97 (10), p.3259-3267

2001

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Novel short chain fatty acids restore chloride secretion in cystic fibrosis

Biochemical and biophysical research communications, 2006-03, Vol.342 (1), p.245-252

2006

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Enhancement of growth and survival and alterations in Bcl-family proteins in β-thalassemic erythroid progenitors by novel short-chain fatty acid derivatives

Blood cells, molecules, & diseases, 2005-09, Vol.35 (2), p.217-226

2005

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Sickle erythrocytes, after sickling, regulate the expression of the endothelin-1 gene and protein in human endothelial cells in culture

The Journal of clinical investigation, 1995-08, Vol.96 (2), p.1145-1151

1995

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Arginine Butyrate-Induced Susceptibility to Ganciclovir in an Epstein–Barr-Virus-Associated Lymphoma

Blood cells, molecules, & diseases, 1998-06, Vol.24 (2), p.114-123

1998

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Hypoxia-activated ligand HAL-1/13 is lupus autoantigen Ku80 and mediates lymphoid cell adhesion in vitro

American Journal of Physiology: Cell Physiology, 2001-04, Vol.280 (4), p.C897-C911

2001

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Alterations in Protein-DNA Interactions in the γ-Globin Gene Promoter in Response to Butyrate Therapy

Blood, 1998-10, Vol.92 (8), p.2924-2933

1998

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Biochemical effect of intravenous arginine butyrate in x-linked adrenoleukodystrophy

The Journal of pediatrics, 2003-06, Vol.142 (6), p.709-713

2003

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Butyrate Infusions in the Ovine Fetus Delay the Biologic Clock for Globin Gene Switching

Proceedings of the National Academy of Sciences - PNAS, 1988-11, Vol.85 (22), p.8540-8542

1988

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Sodium butyrate enhances fetal globin gene expression in erythroid progenitors of patients with Hb SS and β thalassemia

Blood, 1989-07, Vol.74 (1), p.454-459

1989

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Trial of recombinant human erythropoietin: three patients with thalassemia intermedia [letter]

Blood, 1992-12, Vol.80 (12), p.3258-3260

1992

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Delay in the fetal globin switch in infants of diabetic mothers

The New England journal of medicine, 1985-02, Vol.312 (6), p.334-338

1985

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Hypoxia increases thrombospondin-1 transcript and protein in cultured endothelial cells

The Journal of laboratory and clinical medicine, 1998-12, Vol.132 (6), p.519-529

1998

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Erythroid Progenitor Proliferation is Stimulated by Phenoxyacetic and Phenylalkyl Acids

Blood cells, molecules, & diseases, 1996, Vol.22 (2), p.150-158

1996

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Abrogation of IL-3 requirements and stimulation of hematopoietic cell proliferation in vitro and in vivo by carboxylic acids

Blood cells, molecules, & diseases, 1997-12, Vol.23 (3), p.434-442

1997

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Influence of steel factor on hemoglobin synthesis in sickle cell disease

Blood, 1992-04, Vol.79 (7), p.1861-1868

1992

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Butryic acid analogues augment γ globin gene expression in neonatal erythroid progenitors

Biochemical and biophysical research communications, 1987-10, Vol.148 (2), p.694-700

1987

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Fetal Hemoglobin - Biosynthesis
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Butyrates - Pharmacology
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Gene Expression Regulation - Drug Effects
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A phase 1/2 trial of HQK-1001, an oral fetal globin inducer, in sickle cell disease

Sustained Induction of Fetal Hemoglobin by Pulse Butyrate Therapy in Sickle Cell Disease

Isobutyramide, an orally bioavailable butyrate analogue, stimulates fetal globin gene expression in vitro and in vivo

Short-chain fatty acid derivatives induce fetal globin expression and erythropoiesis in vivo

Sickle cell anemia is associated with reduced nitric oxide bioactivity in peripheral conduit and resistance vessels

A Short-Term Trial of Butyrate to Stimulate Fetal-Globin-Gene Expression in the β-Globin Disorders

Induction of the Epstein–Barr virus thymidine kinase gene with concomitant nucleoside antivirals as a therapeutic strategy for Epstein–Barr virus–associated malignancies

Induction of Fetal Globin in β-Thalassemia: Cellular Obstacles and Molecular Progress

Short-chain fatty acid derivatives stimulate cell proliferation and induce STAT-5 activation

Novel short chain fatty acids restore chloride secretion in cystic fibrosis

Enhancement of growth and survival and alterations in Bcl-family proteins in β-thalassemic erythroid progenitors by novel short-chain fatty acid derivatives

Sickle erythrocytes, after sickling, regulate the expression of the endothelin-1 gene and protein in human endothelial cells in culture

Arginine Butyrate-Induced Susceptibility to Ganciclovir in an Epstein–Barr-Virus-Associated Lymphoma

Hypoxia-activated ligand HAL-1/13 is lupus autoantigen Ku80 and mediates lymphoid cell adhesion in vitro

Alterations in Protein-DNA Interactions in the γ-Globin Gene Promoter in Response to Butyrate Therapy

Biochemical effect of intravenous arginine butyrate in x-linked adrenoleukodystrophy

Butyrate Infusions in the Ovine Fetus Delay the Biologic Clock for Globin Gene Switching

Sodium butyrate enhances fetal globin gene expression in erythroid progenitors of patients with Hb SS and β thalassemia

Trial of recombinant human erythropoietin: three patients with thalassemia intermedia [letter]

Delay in the fetal globin switch in infants of diabetic mothers

Hypoxia increases thrombospondin-1 transcript and protein in cultured endothelial cells

Erythroid Progenitor Proliferation is Stimulated by Phenoxyacetic and Phenylalkyl Acids

Abrogation of IL-3 requirements and stimulation of hematopoietic cell proliferation in vitro and in vivo by carboxylic acids

Influence of steel factor on hemoglobin synthesis in sickle cell disease

Butryic acid analogues augment γ globin gene expression in neonatal erythroid progenitors

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