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Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors

Proceedings of the National Academy of Sciences - PNAS, 2018-11, Vol.115 (48), p.12176-12181

2018

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Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

Molecular cell, 2000-10, Vol.6 (4), p.909-919

2000

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ESCRT-I Core and ESCRT-II GLUE Domain Structures Reveal Role for GLUE in Linking to ESCRT-I and Membranes

Cell, 2006-04, Vol.125 (1), p.99-111

2006

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ESCRT-II, an Endosome-Associated Complex Required for Protein Sorting: Crystal Structure and Interactions with ESCRT-III and Membranes

Developmental cell, 2004-10, Vol.7 (4), p.559-569

2004

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An MTOR mutation hitchhikes through embryogenesis, driving multifocal, multiphenotypic renal tumours

European urology open science (Online), 2023-10, Vol.56, p.S14

2023

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P13 - An MTOR mutation hitchhikes through embryogenesis, driving multifocal, multiphenotypic renal tumours

European urology open science (Online), 2023-10, Vol.56, p.S14-S14

2023

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Structural Mechanisms of PI3K and PTEN Regulation

The FASEB journal, 2015-04, Vol.29 (S1)

2015

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A tobacco DNA binding protein that interacts with a light-responsive box II element

The Plant cell, 1992-07, Vol.4 (7), p.831-838

1992

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Robotic nanolitre protein crystallisation at the MRC Laboratory of Molecular Biology

Progress in biophysics and molecular biology, 2005-07, Vol.88 (3), p.311-327

2005

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Binding of the PX domain of p47(phox) to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interaction

The EMBO journal, 2002-10, Vol.21 (19), p.5057

2002

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Crystal Structure and Functional Analysis of Ras Binding to Its Effector Phosphoinositide 3-Kinase γ

Cell, 2000-12, Vol.103 (6), p.931-944

2000

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Structural insights into phosphoinositide 3-kinase catalysis and signalling

Nature (London), 1999-11, Vol.402 (6759), p.313-320

1999

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PB1 Domain-Mediated Heterodimerization in NADPH Oxidase and Signaling Complexes of Atypical Protein Kinase C with Par6 and p62

Molecular cell, 2003-07, Vol.12 (1), p.39-50

2003

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Structural Basis for Arl1-Dependent Targeting of Homodimeric GRIP Domains to the Golgi Apparatus

Molecular cell, 2003-10, Vol.12 (4), p.863-874

2003

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The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate

Molecular cell, 2001-10, Vol.8 (4), p.829-839

2001

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Crystal structure of a mammalian phosphoinositide-specific phospholipase Cδ

Nature (London), 1996-04, Vol.380 (6575), p.595-602

1996

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Crystal Structure of a Calcium-Phospholipid Binding Domain from Cytosolic Phospholipase A2

The Journal of biological chemistry, 1998-01, Vol.273 (3), p.1596-1604

1998

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Calcium-dependent Membrane Penetration Is a Hallmark of the C2 Domain of Cytosolic Phospholipase A2 Whereas the C2A Domain of Synaptotagmin Binds Membranes Electrostatically

The Journal of biological chemistry, 1998-07, Vol.273 (30), p.19093-19096

1998

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Mapping the Phospholipid-binding Surface and Translocation Determinants of the C2 Domain from Cytosolic Phospholipase A2

The Journal of biological chemistry, 1999-05, Vol.274 (21), p.14979-14987

1999

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Evolution and assembly of ESCRTs

Biochemical Society transactions, 2009-02, Vol.37 (Pt 1), p.151-155

2009

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Stable binding of Drosophila heat shock factor to head-to-head and tail-to-tail repeats of a conserved 5 bp recognition unit

Cell, 1989-12, Vol.59 (5), p.797-806

1989

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Protease-activated kinase II as the potential mediator of insulin-stimulated phosphorylation of ribosomal protein S6

The Journal of biological chemistry, 1983-08, Vol.258 (16), p.9589-9592

1983

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Tyrosine Residues in Phospholipase C gamma 2 Essential for the Enzyme Function in B-cell Signaling

The Journal of biological chemistry, 2001-12, Vol.276 (51), p.47982-47992

2001

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Macromolecular crystallization: robotics, procedures and innovations

Acta crystallographica. Section A, Foundations of crystallography, 2011-08, Vol.67 (a1), p.C765-C765

2011

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Crystal structure of a diabody, a bivalent antibody fragment

Structure (London), 1994-12, Vol.2 (12), p.1217-1226

1994

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Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

ESCRT-I Core and ESCRT-II GLUE Domain Structures Reveal Role for GLUE in Linking to ESCRT-I and Membranes

ESCRT-II, an Endosome-Associated Complex Required for Protein Sorting: Crystal Structure and Interactions with ESCRT-III and Membranes

An MTOR mutation hitchhikes through embryogenesis, driving multifocal, multiphenotypic renal tumours

P13 - An MTOR mutation hitchhikes through embryogenesis, driving multifocal, multiphenotypic renal tumours

Structural Mechanisms of PI3K and PTEN Regulation

A tobacco DNA binding protein that interacts with a light-responsive box II element

Robotic nanolitre protein crystallisation at the MRC Laboratory of Molecular Biology

Binding of the PX domain of p47(phox) to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interaction

Crystal Structure and Functional Analysis of Ras Binding to Its Effector Phosphoinositide 3-Kinase γ

Structural insights into phosphoinositide 3-kinase catalysis and signalling

PB1 Domain-Mediated Heterodimerization in NADPH Oxidase and Signaling Complexes of Atypical Protein Kinase C with Par6 and p62

Structural Basis for Arl1-Dependent Targeting of Homodimeric GRIP Domains to the Golgi Apparatus

The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate

Crystal structure of a mammalian phosphoinositide-specific phospholipase Cδ

Crystal Structure of a Calcium-Phospholipid Binding Domain from Cytosolic Phospholipase A2

Calcium-dependent Membrane Penetration Is a Hallmark of the C2 Domain of Cytosolic Phospholipase A2 Whereas the C2A Domain of Synaptotagmin Binds Membranes Electrostatically

Mapping the Phospholipid-binding Surface and Translocation Determinants of the C2 Domain from Cytosolic Phospholipase A2

Evolution and assembly of ESCRTs

Stable binding of Drosophila heat shock factor to head-to-head and tail-to-tail repeats of a conserved 5 bp recognition unit

Protease-activated kinase II as the potential mediator of insulin-stimulated phosphorylation of ribosomal protein S6

Tyrosine Residues in Phospholipase C gamma 2 Essential for the Enzyme Function in B-cell Signaling

Macromolecular crystallization: robotics, procedures and innovations

Crystal structure of a diabody, a bivalent antibody fragment

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