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Mechanism of action of SNF472, a novel calcification inhibitor to treat vascular calcification and calciphylaxis

British journal of pharmacology, 2020-10, Vol.177 (19), p.4400-4415

2020

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Characterization of SNF472 pharmacokinetics and efficacy in uremic and non-uremic rats models of cardiovascular calcification

PloS one, 2018-05, Vol.13 (5), p.e0197061-e0197061

2018

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Direct Covalent Grafting of Phytate to Titanium Surfaces through Ti–O–P Bonding Shows Bone Stimulating Surface Properties and Decreased Bacterial Adhesion

ACS applied materials & interfaces, 2016-05, Vol.8 (18), p.11326-11335

2016

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Relationship between Urinary Level of Phytate and Valvular Calcification in an Elderly Population: A Cross-Sectional Study

PloS one, 2015-08, Vol.10 (8), p.e0136560-e0136560

2015

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Author Correction: A novel assay to measure calcification propensity: from laboratory to humans

Scientific reports, 2021-02, Vol.11 (1), p.4314-4314, Article 4314

2021

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Slowing Progression of Cardiovascular Calcification With SNF472 in Patients on Hemodialysis: Results of a Randomized Phase 2b Study

Circulation (New York, N.Y.), 2020-03, Vol.141 (9), p.728-739

2020

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Plant phosphates, phytate and pathological calcifications in chronic kidney disease

Nefrología, 2017-01, Vol.37 (1), p.20-28

2017

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Hexasodium fytate for the treatment of calciphylaxis: a randomised, double-blind, phase 3, placebo-controlled trial with an open-label extension

EClinicalMedicine, 2024-09, Vol.75, p.102784, Article 102784

2024

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Effect of Crystallization Inhibitors on Vascular Calcifications Induced by Vitamin D: A Pilot Study in Sprague-Dawley Rats

Circulation Journal, 2007, Vol.71(7), pp.1152-1156

2007

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Hexasodium fytate exposure-response correlations in a randomized, placebo-controlled study of patients on dialysis with cardiovascular calcification

Frontiers in pharmacology, 2024-02, Vol.15, p.1325186-1325186

2024

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Phytate levels in biological fluids of mammals

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2014-06, Vol.960, p.255-257

2014

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Effects of Myo-inositol Hexaphosphate (SNF472) on Bone Mineral Density in Patients Receiving Hemodialysis: An Analysis of the Randomized, Placebo-Controlled CaLIPSO Study

Clinical journal of the American Society of Nephrology, 2021-05, Vol.16 (5), p.736-745

2021

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Determination of uric acid in urine, saliva and calcium oxalate renal calculi by high-performance liquid chromatography/mass spectrometry

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005-09, Vol.824 (1), p.175-180

2005

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Inositol hexakisphosphate inhibits osteoclastogenesis on RAW 264.7 cells and human primary osteoclasts

PloS one, 2012-08, Vol.7 (8), p.e43187-e43187

2012

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Improvement in wound healing, pain, and quality of life after 12 weeks of SNF472 treatment: a phase 2 open-label study of patients with calciphylaxis

Journal of nephrology, 2019-10, Vol.32 (5), p.811-821

2019

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Fosfatos de origen vegetal, fitato y calcificaciones patológicas en la enfermedad renal crónica

Nefrología, 2017-01, Vol.37 (1), p.20-28

2017

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A phase 1b randomized, placebo‐controlled clinical trial with SNF472 in haemodialysis patients

British journal of clinical pharmacology, 2019-04, Vol.85 (4), p.796-806

2019

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SNF472 Improves Limb Blood Perfusion and Walking Ability and Inhibits Progression of Calcification in Femoral Arteries in a Rat Model of Peripheral Artery Disease

Journal of vascular surgery, 2021-09, Vol.74 (3), p.e62-e63

2021

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FC 107SNF472 ATTENUATES THE PROGRESSION OF FEMORAL ARTERY CALCIFICATION AND RECOVERS LIMB BLOOD PERFUSION AND WALKING ABILITY IN A RAT MODEL OF PERIPHERAL ARTERY DISEASE

Nephrology, dialysis, transplantation, 2021-05, Vol.36 (Supplement_1)

2021

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Validation of an LC–MS bioanalytical method for quantification of phytate levels in rat, dog and human plasma

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2013-06, Vol.928, p.146-154

2013

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Plant phosphates, phytate and pathological calcifications in chronic kidney disease

Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2017-01, Vol.37 (1), p.20-28

2017

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The CALCIPHYX study: a randomized, double-blind, placebo-controlled, Phase 3 clinical trial of SNF472 for the treatment of calciphylaxis

Clinical kidney journal, 2022-01, Vol.15 (1), p.136-144

2022

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A novel assay to measure calcification propensity: from laboratory to humans

Scientific reports, 2020-10, Vol.10 (1), p.17578, Article 17578

2020

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P0884MYO-INOSITOL HEXAPHOSPHATE PEGYLATION IMPROVES BIOAVAILABILITY BUT REDUCES ITS ANTI-VASCULAR CALCIFICATION EFFECT IN RATS

Nephrology, dialysis, transplantation, 2020-06, Vol.35 (Supplement_3)

2020

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P1234SNF472 IMPROVES LIMB BLOOD PERFUSION AND WALKING ABILITY IN A PERIPHERAL ARTERY DISEASE VASCULAR CALCIFICATION RAT MODEL

Nephrology, dialysis, transplantation, 2020-06, Vol.35 (Supplement_3)

2020

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Mechanism of action of SNF472, a novel calcification inhibitor to treat vascular calcification and calciphylaxis

Characterization of SNF472 pharmacokinetics and efficacy in uremic and non-uremic rats models of cardiovascular calcification

Direct Covalent Grafting of Phytate to Titanium Surfaces through Ti–O–P Bonding Shows Bone Stimulating Surface Properties and Decreased Bacterial Adhesion

Relationship between Urinary Level of Phytate and Valvular Calcification in an Elderly Population: A Cross-Sectional Study

Author Correction: A novel assay to measure calcification propensity: from laboratory to humans

Slowing Progression of Cardiovascular Calcification With SNF472 in Patients on Hemodialysis: Results of a Randomized Phase 2b Study

Plant phosphates, phytate and pathological calcifications in chronic kidney disease

Hexasodium fytate for the treatment of calciphylaxis: a randomised, double-blind, phase 3, placebo-controlled trial with an open-label extension

Effect of Crystallization Inhibitors on Vascular Calcifications Induced by Vitamin D: A Pilot Study in Sprague-Dawley Rats

Hexasodium fytate exposure-response correlations in a randomized, placebo-controlled study of patients on dialysis with cardiovascular calcification

Phytate levels in biological fluids of mammals

Effects of Myo-inositol Hexaphosphate (SNF472) on Bone Mineral Density in Patients Receiving Hemodialysis: An Analysis of the Randomized, Placebo-Controlled CaLIPSO Study

Determination of uric acid in urine, saliva and calcium oxalate renal calculi by high-performance liquid chromatography/mass spectrometry

Inositol hexakisphosphate inhibits osteoclastogenesis on RAW 264.7 cells and human primary osteoclasts

Improvement in wound healing, pain, and quality of life after 12 weeks of SNF472 treatment: a phase 2 open-label study of patients with calciphylaxis

Fosfatos de origen vegetal, fitato y calcificaciones patológicas en la enfermedad renal crónica

A phase 1b randomized, placebo‐controlled clinical trial with SNF472 in haemodialysis patients

SNF472 Improves Limb Blood Perfusion and Walking Ability and Inhibits Progression of Calcification in Femoral Arteries in a Rat Model of Peripheral Artery Disease

FC 107SNF472 ATTENUATES THE PROGRESSION OF FEMORAL ARTERY CALCIFICATION AND RECOVERS LIMB BLOOD PERFUSION AND WALKING ABILITY IN A RAT MODEL OF PERIPHERAL ARTERY DISEASE

Validation of an LC–MS bioanalytical method for quantification of phytate levels in rat, dog and human plasma

Plant phosphates, phytate and pathological calcifications in chronic kidney disease

The CALCIPHYX study: a randomized, double-blind, placebo-controlled, Phase 3 clinical trial of SNF472 for the treatment of calciphylaxis

A novel assay to measure calcification propensity: from laboratory to humans

P0884MYO-INOSITOL HEXAPHOSPHATE PEGYLATION IMPROVES BIOAVAILABILITY BUT REDUCES ITS ANTI-VASCULAR CALCIFICATION EFFECT IN RATS

P1234SNF472 IMPROVES LIMB BLOOD PERFUSION AND WALKING ABILITY IN A PERIPHERAL ARTERY DISEASE VASCULAR CALCIFICATION RAT MODEL

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