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Synthesis and antiproliferative evaluation of 5- oxo and 5-thio derivatives of 1,4-diaryl tetrazoles

Bioorganic & medicinal chemistry letters, 2010-07, Vol.20 (13), p.3920-3924

2010

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Novel synthetic inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase activity that inhibit tumor cell proliferation and are structurally unrelated to existing statins

International journal of molecular medicine, 2009-11, Vol.24 (5), p.633-643

2009

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Mechanisms by which synthetic 6,7-annulated-4-substituted indole compounds with anti-proliferative activity disrupt mitosis and block cytokinesis in human HL-60 tumor cells in vitro

Anticancer research, 2014-04, Vol.34 (4), p.1643-1656

2014

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Antitumor Effects of Synthetic 6,7-Annulated-4-substituted Indole Compounds in L1210 Leukemic Cells In Vitro

Anticancer research, 2012-11, Vol.32 (11), p.4671-4684

2012

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Bioactivity of Synthetic 2-Halo-3-aryl-4(3H)-quinazoliniminium Halides in L1210 Leukemia and SK-BR-3 Mammary Tumor Cells In Vitro

Anticancer research, 2011-06, Vol.31 (6), p.2083-2093

2011

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Synthesis, molecular targets, and antitumor activities of substituted tetrahydro-1-oxopyrano[4,3-b][1]benzopyrans and nanogels for drug delivery

Anti-cancer agents in medicinal chemistry, 2009-10, Vol.9 (8), p.864-876

2009

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Synthesis of a natural product-inspired eight-membered ring lactam library via ring-closing metathesis

Bioorganic & medicinal chemistry, 2008-09, Vol.18 (17), p.4876-4879

2008

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Bioactivity and molecular targets of novel substituted quinolines in murine and human tumor cell lines in vitro

International journal of oncology, 2010-03, Vol.36 (3), p.673-688

2010

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Overexpression of eIF5 or its protein mimic 5MP perturbs eIF2 function and induces ATF4 translation through delayed re-initiation

Nucleic acids research, 2016-10, Vol.44 (18), p.8704-8713

2016

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Antiproliferative and Proapoptotic Activities of Pyranoxanthenones, Pyranothioxanthenones and their Pyrazole-fused Derivatives in HL-60 Cells

Anticancer research, 2006-07, Vol.26 (4B), p.2791-2804

2006

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Antitumor Triptycene Analogs Directly Interact with Isolated Mitochondria to Rapidly Trigger Markers of Permeability Transition

Anticancer research, 2007-09, Vol.27 (5A), p.3259-3271

2007

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Syntheses, molecular targets and antitumor activities of novel triptycene bisquinones and 1,4-anthracenedione analogs

Anti-cancer agents in medicinal chemistry, 2006-07, Vol.6 (4), p.303-318

2006

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Novel substituted 1,4-anthracenediones with antitumor activity directly induce permeability transition in isolated mitochondria

International journal of oncology, 2007-11, Vol.31 (5), p.1231-1241

2007

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Total syntheses of (±)-ovalicin, C4( S ∗)-isomer, and its C5-analogs and anti-trypanosomal activities

Bioorganic & medicinal chemistry, 2008-05, Vol.16 (9), p.5232-5246

2008

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Antitumor triptycene analogs induce a rapid collapse of mitochondrial transmembrane potential in HL-60 cells and isolated mitochondria

International journal of oncology, 2006, Vol.28 (1), p.161-172

2006

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Rapid collapse of mitochondrial transmembrane potential in HL-60 cells and isolated mitochondria treated with anti-tumor 1,4-anthracenediones

Anti-cancer drugs, 2005-10, Vol.16 (9), p.953-967

2005

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Antitumor triptycene bisquinones induce a caspase-independent release of mitochondrial cytochrome c and a caspase-2-mediated activation of initiator caspase-8 and -9 in HL-60 cells by a mechanism which does not involve Fas signaling

Anti-cancer drugs, 2004-11, Vol.15 (10), p.929-946

2004

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Induction of poly(ADP-ribose) polymerase-1 cleavage by antitumor triptycene bisquinones in wild-type and daunorubicin-resistant HL-60 cell lines

Cancer letters, 2002-12, Vol.188 (1), p.73-83

2002

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Antioxidants and multistage carcinogenesis in mouse skin

Free Radical Biology and Medicine, 1989, Vol.7 (4), p.377-408

1989

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Antitumor triptycene bisquinones: a novel synthetic class of dual inhibitors of DNA topoisomerase I and II activities

Anti-cancer drugs, 2003-08, Vol.14 (7), p.503-514

2003

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Imidazole-4,5-dicarboxamide Derivatives with Antiproliferative Activity against HL-60 Cells

Journal of medicinal chemistry, 2005-09, Vol.48 (19), p.5955-5965

2005

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Total Syntheses of (+)-Chloropuupehenone and (+)-Chloropuupehenol and Their Analogues and Evaluation of Their Bioactivities

Journal of organic chemistry, 2004-09, Vol.69 (18), p.6065-6078

2004

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Syntheses and Bioactivities of Substituted 9,10-Dihydro-9,10-[1,2]benzenoanthracene-1,4,5,8-tetrones. Unusual Reactivities with Amines

Journal of organic chemistry, 2002-05, Vol.67 (9), p.2907-2912

2002

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Synthesis and in vitro antitumor activity of substituted anthracene-1,4-diones

Tetrahedron, 2004-11, Vol.60 (45), p.10155-10163

2004

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Synthetic 1,4-anthracenedione analogs induce cytochrome c release, caspase-9, -3, and -8 activities, poly(ADP-ribose) polymerase-1 cleavage and internucleosomal DNA fragmentation in HL-60 cells by a mechanism which involves caspase-2 activation but not Fas signaling

Biochemical pharmacology, 2004-02, Vol.67 (3), p.523-537

2004

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Synthesis and antiproliferative evaluation of 5- oxo and 5-thio derivatives of 1,4-diaryl tetrazoles

Novel synthetic inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase activity that inhibit tumor cell proliferation and are structurally unrelated to existing statins

Mechanisms by which synthetic 6,7-annulated-4-substituted indole compounds with anti-proliferative activity disrupt mitosis and block cytokinesis in human HL-60 tumor cells in vitro

Antitumor Effects of Synthetic 6,7-Annulated-4-substituted Indole Compounds in L1210 Leukemic Cells In Vitro

Bioactivity of Synthetic 2-Halo-3-aryl-4(3H)-quinazoliniminium Halides in L1210 Leukemia and SK-BR-3 Mammary Tumor Cells In Vitro

Synthesis, molecular targets, and antitumor activities of substituted tetrahydro-1-oxopyrano[4,3-b][1]benzopyrans and nanogels for drug delivery

Synthesis of a natural product-inspired eight-membered ring lactam library via ring-closing metathesis

Bioactivity and molecular targets of novel substituted quinolines in murine and human tumor cell lines in vitro

Overexpression of eIF5 or its protein mimic 5MP perturbs eIF2 function and induces ATF4 translation through delayed re-initiation

Antiproliferative and Proapoptotic Activities of Pyranoxanthenones, Pyranothioxanthenones and their Pyrazole-fused Derivatives in HL-60 Cells

Antitumor Triptycene Analogs Directly Interact with Isolated Mitochondria to Rapidly Trigger Markers of Permeability Transition

Syntheses, molecular targets and antitumor activities of novel triptycene bisquinones and 1,4-anthracenedione analogs

Novel substituted 1,4-anthracenediones with antitumor activity directly induce permeability transition in isolated mitochondria

Total syntheses of (±)-ovalicin, C4( S ∗)-isomer, and its C5-analogs and anti-trypanosomal activities

Antitumor triptycene analogs induce a rapid collapse of mitochondrial transmembrane potential in HL-60 cells and isolated mitochondria

Rapid collapse of mitochondrial transmembrane potential in HL-60 cells and isolated mitochondria treated with anti-tumor 1,4-anthracenediones

Antitumor triptycene bisquinones induce a caspase-independent release of mitochondrial cytochrome c and a caspase-2-mediated activation of initiator caspase-8 and -9 in HL-60 cells by a mechanism which does not involve Fas signaling

Induction of poly(ADP-ribose) polymerase-1 cleavage by antitumor triptycene bisquinones in wild-type and daunorubicin-resistant HL-60 cell lines

Antioxidants and multistage carcinogenesis in mouse skin

Antitumor triptycene bisquinones: a novel synthetic class of dual inhibitors of DNA topoisomerase I and II activities

Imidazole-4,5-dicarboxamide Derivatives with Antiproliferative Activity against HL-60 Cells

Total Syntheses of (+)-Chloropuupehenone and (+)-Chloropuupehenol and Their Analogues and Evaluation of Their Bioactivities

Syntheses and Bioactivities of Substituted 9,10-Dihydro-9,10-[1,2]benzenoanthracene-1,4,5,8-tetrones. Unusual Reactivities with Amines

Synthesis and in vitro antitumor activity of substituted anthracene-1,4-diones

Synthetic 1,4-anthracenedione analogs induce cytochrome c release, caspase-9, -3, and -8 activities, poly(ADP-ribose) polymerase-1 cleavage and internucleosomal DNA fragmentation in HL-60 cells by a mechanism which involves caspase-2 activation but not Fas signaling

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