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Human Aldo-Keto Reductases and the Metabolic Activation of Polycyclic Aromatic Hydrocarbons

Chemical research in toxicology, 2014-11, Vol.27 (11), p.1901-1917

Penning, Trevor M

2014

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Aldo-Keto Reductase Regulation by the Nrf2 System: Implications for Stress Response, Chemotherapy Drug Resistance, and Carcinogenesis

Chemical research in toxicology, 2017-01, Vol.30 (1), p.162-176

Penning, Trevor M

2017

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Steroid Biochemistry

Penning, Trevor M

1, 2023

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Aldo-Keto Reductase (AKR) 1C3 inhibitors: a patent review

Expert opinion on therapeutic patents, 2017-12, Vol.27 (12), p.1329-1340

Penning, Trevor M.

2017

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Structural and Functional Biology of Aldo-Keto Reductase Steroid-Transforming Enzymes

Endocrine reviews, 2019-04, Vol.40 (2), p.447-475

2019

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Role of aldo–keto reductase family 1 (AKR1) enzymes in human steroid metabolism

Steroids, 2014-01, Vol.79, p.49-63

2014

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Aldo-keto reductases and bioactivation/detoxication

Annual review of pharmacology and toxicology, 2007-01, Vol.47 (1), p.263-292

2007

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Conversion of Classical and 11-Oxygenated Androgens by Insulin-Induced AKR1C3 in a Model of Human PCOS Adipocytes

Endocrinology (Philadelphia), 2022-07, Vol.163 (7), p.1

2022

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Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer

Trends in endocrinology and metabolism, 2010-05, Vol.21 (5), p.315-324

2010

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5β-Dihydrosteroids: Formation and Properties

International journal of molecular sciences, 2024-08, Vol.25 (16), p.8857

2024

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The aldo-keto reductases (AKRs): Overview

Chemico-biological interactions, 2015-06, Vol.234, p.236-246

Penning, Trevor M.

2015

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AKR1C3 as a target in castrate resistant prostate cancer

The Journal of steroid biochemistry and molecular biology, 2013-09, Vol.137, p.136-149

2013

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Characterization of the major single nucleotide polymorphic variants of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase)

The Journal of steroid biochemistry and molecular biology, 2022-07, Vol.221, p.106121-106121, Article 106121

2022

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Human aldo–keto reductases: Function, gene regulation, and single nucleotide polymorphisms

Archives of biochemistry and biophysics, 2007-08, Vol.464 (2), p.241-250

2007

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Biology and clinical relevance of Hydroxysteroid (17beta) dehydrogenase enzymes

Molecular and cellular endocrinology, 2019-06, Vol.489, p.1-2

2019

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Germline Mutations in Steroid Metabolizing Enzymes: A Focus on Steroid Transforming Aldo-Keto Reductases

International journal of molecular sciences, 2023-01, Vol.24 (3), p.1873

2023

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AKR1C3 (type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase): Roles in malignancy and endocrine disorders

Molecular and cellular endocrinology, 2019-06, Vol.489, p.82-91

Penning, Trevor M.

2019

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Steroid Hormone Transforming Aldo-Keto Reductases and Cancer

Annals of the New York Academy of Sciences, 2009-02, Vol.1155 (1), p.33-42

2009

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Unconventional Gas and Oil Drilling Is Associated with Increased Hospital Utilization Rates

PloS one, 2015-07, Vol.10 (7), p.e0131093

2015

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Contribution of Adrenal Glands to Intratumor Androgens and Growth of Castration-Resistant Prostate Cancer

Clinical cancer research, 2019-01, Vol.25 (1), p.426-439

2019

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Induction of the Antioxidant Response by the Transcription Factor NRF2 Increases Bioactivation of the Mutagenic Air Pollutant 3‑Nitrobenzanthrone in Human Lung Cells

Chemical research in toxicology, 2019-12, Vol.32 (12), p.2538-2551

2019

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Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer

Cancer research (Chicago, Ill.), 2006-03, Vol.66 (5), p.2815-2825

2006

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AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease

Metabolism, clinical and experimental, 2019-10, Vol.99, p.67-80

2019

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AKR1C3 Inhibitor KV-37 Exhibits Antineoplastic Effects and Potentiates Enzalutamide in Combination Therapy in Prostate Adenocarcinoma Cells

Molecular cancer therapeutics, 2018-09, Vol.17 (9), p.1833-1845

2018

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Genotoxicity of ortho-quinones: reactive oxygen species versus covalent modification

Toxicology research (Cambridge), 2017, Vol.6 (6), p.74-754

Penning, Trevor M

2017

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Human Aldo-Keto Reductases and the Metabolic Activation of Polycyclic Aromatic Hydrocarbons

Aldo-Keto Reductase Regulation by the Nrf2 System: Implications for Stress Response, Chemotherapy Drug Resistance, and Carcinogenesis

Steroid Biochemistry

Aldo-Keto Reductase (AKR) 1C3 inhibitors: a patent review

Structural and Functional Biology of Aldo-Keto Reductase Steroid-Transforming Enzymes

Role of aldo–keto reductase family 1 (AKR1) enzymes in human steroid metabolism

Aldo-keto reductases and bioactivation/detoxication

Conversion of Classical and 11-Oxygenated Androgens by Insulin-Induced AKR1C3 in a Model of Human PCOS Adipocytes

Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer

5β-Dihydrosteroids: Formation and Properties

The aldo-keto reductases (AKRs): Overview

AKR1C3 as a target in castrate resistant prostate cancer

Characterization of the major single nucleotide polymorphic variants of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase)

Human aldo–keto reductases: Function, gene regulation, and single nucleotide polymorphisms

Biology and clinical relevance of Hydroxysteroid (17beta) dehydrogenase enzymes

Germline Mutations in Steroid Metabolizing Enzymes: A Focus on Steroid Transforming Aldo-Keto Reductases

AKR1C3 (type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase): Roles in malignancy and endocrine disorders

Steroid Hormone Transforming Aldo-Keto Reductases and Cancer

Unconventional Gas and Oil Drilling Is Associated with Increased Hospital Utilization Rates

Contribution of Adrenal Glands to Intratumor Androgens and Growth of Castration-Resistant Prostate Cancer

Induction of the Antioxidant Response by the Transcription Factor NRF2 Increases Bioactivation of the Mutagenic Air Pollutant 3‑Nitrobenzanthrone in Human Lung Cells

Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer

AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease

AKR1C3 Inhibitor KV-37 Exhibits Antineoplastic Effects and Potentiates Enzalutamide in Combination Therapy in Prostate Adenocarcinoma Cells

Genotoxicity of ortho-quinones: reactive oxygen species versus covalent modification

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