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Geranylgeranyltransferase I Inhibitors Target RalB To Inhibit Anchorage-Dependent Growth and Induce Apoptosis and RalA To Inhibit Anchorage-Independent Growth

Molecular and Cellular Biology, 2007-11, Vol.27 (22), p.8003-8014

2007

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Novel Bicyclic Piperazine Derivatives of Triazolotriazine and Triazolopyrimidines as Highly Potent and Selective Adenosine A2A Receptor Antagonists

Journal of medicinal chemistry, 2004-12, Vol.47 (25), p.6218-6229

2004

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Discovery of 4-aminomethylphenylacetic acids as γ-secretase modulators via a scaffold design approach

Bioorganic & medicinal chemistry letters, 2011-12, Vol.21 (24), p.7277-7280

2011

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Synthesis and evaluation of potent, highly-selective, 3-aryl-piperazinone inhibitors of protein geranylgeranyltransferase-I

Organic & biomolecular chemistry, 2006-01, Vol.4 (9), p.1768-1784

2006

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Blockade of Protein Geranylgeranylation Inhibits Cdk2-Dependent p27Kip1 Phosphorylation on Thr187 and Accumulates p27Kip1 in the Nucleus: Implications for Breast Cancer Therapy

Molecular and Cellular Biology, 2009-04, Vol.29 (8), p.2254-2263

2009

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Syntheses and Biological Activities of a Novel Group of Steroidal Derived Inhibitors for Human CDC25A Protein Phosphatase

Journal of medicinal chemistry, 2001-03, Vol.44 (5), p.834-848

2001

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Acceleration of Petasis Reactions of Salicylaldehyde Derivatives with Molecular Sieves

Journal of organic chemistry, 2012-01, Vol.77 (2), p.1154-1160

2012

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Eight New Eremophilane Derivatives from the Roots of Ligularia przewalskii

Journal of natural products (Washington, D.C.), 1995-09, Vol.58 (9), p.1358-1364

1995

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Structure–activity relationship of Aza-steroids as PI-PLC inhibitors

Bioorganic & medicinal chemistry, 2001-05, Vol.9 (5), p.1073-1083

2001

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Investigating small molecules to inhibit germinal center kinase-like kinase (GLK/MAP4K3) upstream of PKCθ phosphorylation: Potential therapy to modulate T cell dependent immunity

Bioorganic & medicinal chemistry letters, 2018-06, Vol.28 (10), p.1964-1971

2018

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3β-Hydroxy-6-aza-cholestane and related analogues as phosphatidylinositol specific phospholipase C (PI-PLC) inhibitors with antitumor activity

Bioorganic & medicinal chemistry, 2000-04, Vol.8 (4), p.699-706

2000

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BIIB042, a novel γ-secretase modulator, reduces amyloidogenic Aβ isoforms in primates and rodents and plaque pathology in a mouse model of Alzheimer's disease

Neuropharmacology, 2016-04, Vol.103, p.57-68

2016

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Novel CDC25A Phosphatase Inhibitors from Pyrolysis of 3-α-Azido-B-homo-6-oxa-4-cholesten-7-one on Silica Gel

Journal of medicinal chemistry, 1998-11, Vol.41 (24), p.4677-4680

1998

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First Synthesis of Piperazine-derived [1,2,4]Triazolo[1,5-a]pyrazine as an Adenosine A2A Receptor Antagonist

Heterocycles, 2005-10, Vol.65 (10), p.2321

2005

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Six New Eremophilane Derivatives from Two Ligularia Species

Journal of natural products (Washington, D.C.), 1994-12, Vol.57 (12), p.1626-1630

1994

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Steroidal derived acids as inhibitors of human Cdc25A protein phosphatase

Bioorganic & medicinal chemistry, 2000-02, Vol.8 (2), p.299-306

2000

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Discovery of BIIB042, a Potent, Selective, and Orally Bioavailable γ-Secretase Modulator

ACS medicinal chemistry letters, 2011-10, Vol.2 (10), p.786-791

2011

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Discovery of 4-aminomethylphenylacetic acids as I3-secretase modulators via a scaffold design approach

Bioorganic & medicinal chemistry letters, 2011-12, Vol.21 (24), p.7277-7280

2011

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Synthesis and MEK1 inhibitory activities of imido-Substituted 2-chloro-1,4-naphthoquinones

Bioorganic & medicinal chemistry, 2003-07, Vol.11 (14), p.3165-3170

2003

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Novel Bicyclic Piperazine Derivatives of Triazolotriazine and Triazolopyrimidines as Highly Potent and Selective Adenosine A 2 A Receptor Antagonists

Journal of medicinal chemistry, 2004-12, Vol.47 (25), p.6218-6229

2004

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Novel pyrrolo-quinoline derivatives as potent inhibitors for PI3-kinase related kinases

Bioorganic & medicinal chemistry, 2002, Vol.10 (1), p.167-174

2002

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Cdc25A Protein phosphatase inhibitors from anomalous ozonolysis of 5,6-seco-5-oxo-3-cholesten-6-oic acid

Tetrahedron, 2001-03, Vol.57 (10), p.1891-1896

2001

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Potential anticancer agents active against oncogenic cell cycle and signal transduction components

Peng, Hairuo

2000

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Blockade of Protein Geranylgeranylation Inhibits Cdk2-Dependent p27 Kip1 Phosphorylation on Thr187 and Accumulates p27 Kip1 in the Nucleus: Implications for Breast Cancer Therapy

Molecular and cellular biology, 2009-04, Vol.29 (8), p.2254-2263

2009

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Novel CDC25A Phosphatase Inhibitors from Pyrolysis of 3-α-Azido-B-homo-6-oxa-4-cholesten-7-one on Silica Gel

Journal of medicinal chemistry, 1999-05, Vol.42 (9), p.1682-1682

1999

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Geranylgeranyltransferase I Inhibitors Target RalB To Inhibit Anchorage-Dependent Growth and Induce Apoptosis and RalA To Inhibit Anchorage-Independent Growth

Novel Bicyclic Piperazine Derivatives of Triazolotriazine and Triazolopyrimidines as Highly Potent and Selective Adenosine A2A Receptor Antagonists

Discovery of 4-aminomethylphenylacetic acids as γ-secretase modulators via a scaffold design approach

Synthesis and evaluation of potent, highly-selective, 3-aryl-piperazinone inhibitors of protein geranylgeranyltransferase-I

Blockade of Protein Geranylgeranylation Inhibits Cdk2-Dependent p27Kip1 Phosphorylation on Thr187 and Accumulates p27Kip1 in the Nucleus: Implications for Breast Cancer Therapy

Syntheses and Biological Activities of a Novel Group of Steroidal Derived Inhibitors for Human CDC25A Protein Phosphatase

Acceleration of Petasis Reactions of Salicylaldehyde Derivatives with Molecular Sieves

Eight New Eremophilane Derivatives from the Roots of Ligularia przewalskii

Structure–activity relationship of Aza-steroids as PI-PLC inhibitors

Investigating small molecules to inhibit germinal center kinase-like kinase (GLK/MAP4K3) upstream of PKCθ phosphorylation: Potential therapy to modulate T cell dependent immunity

3β-Hydroxy-6-aza-cholestane and related analogues as phosphatidylinositol specific phospholipase C (PI-PLC) inhibitors with antitumor activity

BIIB042, a novel γ-secretase modulator, reduces amyloidogenic Aβ isoforms in primates and rodents and plaque pathology in a mouse model of Alzheimer's disease

Novel CDC25A Phosphatase Inhibitors from Pyrolysis of 3-α-Azido-B-homo-6-oxa-4-cholesten-7-one on Silica Gel

First Synthesis of Piperazine-derived [1,2,4]Triazolo[1,5-a]pyrazine as an Adenosine A2A Receptor Antagonist

Six New Eremophilane Derivatives from Two Ligularia Species

Steroidal derived acids as inhibitors of human Cdc25A protein phosphatase

Discovery of BIIB042, a Potent, Selective, and Orally Bioavailable γ-Secretase Modulator

Discovery of 4-aminomethylphenylacetic acids as I3-secretase modulators via a scaffold design approach

Synthesis and MEK1 inhibitory activities of imido-Substituted 2-chloro-1,4-naphthoquinones

Novel Bicyclic Piperazine Derivatives of Triazolotriazine and Triazolopyrimidines as Highly Potent and Selective Adenosine A 2 A Receptor Antagonists

Novel pyrrolo-quinoline derivatives as potent inhibitors for PI3-kinase related kinases

Cdc25A Protein phosphatase inhibitors from anomalous ozonolysis of 5,6-seco-5-oxo-3-cholesten-6-oic acid

Potential anticancer agents active against oncogenic cell cycle and signal transduction components

Blockade of Protein Geranylgeranylation Inhibits Cdk2-Dependent p27 Kip1 Phosphorylation on Thr187 and Accumulates p27 Kip1 in the Nucleus: Implications for Breast Cancer Therapy

Novel CDC25A Phosphatase Inhibitors from Pyrolysis of 3-α-Azido-B-homo-6-oxa-4-cholesten-7-one on Silica Gel

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