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Safety, efficacy, and dose response of the maturation inhibitor GSK3532795 (formerly known as BMS-955176) plus tenofovir/emtricitabine once daily in treatment-naive HIV-1-infected adults: Week 24 primary analysis from a randomized Phase IIb trial

PloS one, 2018-10, Vol.13 (10), p.e0205368-e0205368

2018

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Population pharmacokinetic modeling of dolutegravir/lamivudine to support a once-daily fixed-dose combination regimen in virologically suppressed adults living with HIV-1

Antimicrobial agents and chemotherapy, 2024-05, Vol.68 (5), p.e0150423

2024

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Phase I Study of the Novel Enhancer of Zeste Homolog 2 (EZH2) Inhibitor GSK2816126 in Patients with Advanced Hematologic and Solid Tumors

Clinical cancer research, 2019-12, Vol.25 (24), p.7331-7339

2019

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A Phase I Evaluation of the Pharmacokinetics and Tolerability of the HIV-1 Maturation Inhibitor GSK3640254 and Tenofovir Alafenamide/Emtricitabine in Healthy Participants

Antimicrobial agents and chemotherapy, 2021-05, Vol.65 (6)

2021

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Lack of pharmacokinetic interaction between the HIV‐1 maturation inhibitor GSK3640254 and combination oral contraceptives in healthy women

British journal of clinical pharmacology, 2022-02, Vol.88 (4), p.1704-1712

2022

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Expression of a Src Family Kinase in Chronic Myelogenous Leukemia Cells Induces Resistance to Imatinib in a Kinase-dependent Manner

The Journal of biological chemistry, 2010-07, Vol.285 (28), p.21446-21457

2010

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Myosins II and V in chromaffin cells: myosin V is a chromaffin vesicle molecular motor involved in secretion

Journal of neurochemistry, 2003-04, Vol.85 (2), p.287-298

2003

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Relative Bioavailability and Food Effect of GSK3640254 Tablet and Capsule Formulations in Healthy Participants

Clinical pharmacology in drug development, 2022-05, Vol.11 (5), p.632-639

2022

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Small Molecule Modulators of Endogenous and Co-chaperone-stimulated Hsp70 ATPase Activity

The Journal of biological chemistry, 2004-12, Vol.279 (49), p.51131-51140

2004

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Conformational disturbance in Abl kinase upon mutation and deregulation

Proceedings of the National Academy of Sciences - PNAS, 2009-02, Vol.106 (5), p.1386-1391

2009

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Bioequivalence and Food Effect Assessment of 2 Fixed‐Dose Combination Formulations of Dolutegravir and Lamivudine

Clinical pharmacology in drug development, 2020-02, Vol.9 (2), p.189-202

2020

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Src Family Kinase Activity Is Required for Murine Embryonic Stem Cell Growth and Differentiation

Molecular pharmacology, 2005-11, Vol.68 (5), p.1320-1330

2005

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Is Placebo Response Responsible for Many Phase III Failures?

Clinical pharmacology and therapeutics, 2019-12, Vol.106 (6), p.1151-1154

2019

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Is Placebo Response Responsible for Many Phase III Failures?

Clinical pharmacology and therapeutics, 2019-12, Vol.106 (6), p.1151-1154

2019

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Expression of various scinderin domains in chromaffin cells indicates that this protein acts as a molecular switch in the control of actin filament dynamics and exocytosis

Journal of neurochemistry, 2005-02, Vol.92 (4), p.780-789

2005

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Population Pharmacokinetics and Pharmacodynamics Modelling of Dilmapimod in Severe Trauma Subjects at Risk for Acute Respiratory Distress Syndrome

Drugs in R&D, 2017-03, Vol.17 (1), p.145-158

2017

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Phase IIa Proof-of-Concept Evaluation of the Antiviral Efficacy, Safety, Tolerability, and Pharmacokinetics of the Next-Generation Maturation Inhibitor GSK3640254

Clinical infectious diseases, 2022-09, Vol.75 (5), p.786-794

2022

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The FEAR Before MEN: Networks of Mitotic Exit

Cell cycle (Georgetown, Tex.), 2002-09, Vol.1 (5), p.304-307

2002

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Pharmacometrics-guided drug development of antihyperhidrosis agents

Journal of clinical pharmacology, 2015-11, Vol.55 (11), p.1256-1267

2015

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Abstract 3687: Expression of a Src-family kinase in CML cells induces resistance to imatinib in a kinase-dependent manner

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8_Supplement), p.3687-3687

2010

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Abl N-Terminal Cap Stabilization of SH3 Domain Dynamics

Biochemistry (Easton), 2008-05, Vol.47 (21), p.5795-5803

2008

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HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck

BMC chemical biology, 2012-03, Vol.12 (1), p.1-1, Article 1

2012

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Molecular Motors Involved in Chromaffin Cell Secretion

Annals of the New York Academy of Sciences, 2002-10, Vol.971 (1), p.222-231

2002

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Investigating the Src kinase Hck functions in chronic myelogenous leukemia using chemical genetics methods

Pene Dumitrescu, Teodora

2009

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ProQuest

The role of different scinderin domains in the control of actin filament dynamics and regulated exocytosis

Pene-Dumitrescu, Teodora

2001

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Safety, efficacy, and dose response of the maturation inhibitor GSK3532795 (formerly known as BMS-955176) plus tenofovir/emtricitabine once daily in treatment-naive HIV-1-infected adults: Week 24 primary analysis from a randomized Phase IIb trial

Population pharmacokinetic modeling of dolutegravir/lamivudine to support a once-daily fixed-dose combination regimen in virologically suppressed adults living with HIV-1

Phase I Study of the Novel Enhancer of Zeste Homolog 2 (EZH2) Inhibitor GSK2816126 in Patients with Advanced Hematologic and Solid Tumors

A Phase I Evaluation of the Pharmacokinetics and Tolerability of the HIV-1 Maturation Inhibitor GSK3640254 and Tenofovir Alafenamide/Emtricitabine in Healthy Participants

Lack of pharmacokinetic interaction between the HIV‐1 maturation inhibitor GSK3640254 and combination oral contraceptives in healthy women

Expression of a Src Family Kinase in Chronic Myelogenous Leukemia Cells Induces Resistance to Imatinib in a Kinase-dependent Manner

Myosins II and V in chromaffin cells: myosin V is a chromaffin vesicle molecular motor involved in secretion

Relative Bioavailability and Food Effect of GSK3640254 Tablet and Capsule Formulations in Healthy Participants

Small Molecule Modulators of Endogenous and Co-chaperone-stimulated Hsp70 ATPase Activity

Conformational disturbance in Abl kinase upon mutation and deregulation

Bioequivalence and Food Effect Assessment of 2 Fixed‐Dose Combination Formulations of Dolutegravir and Lamivudine

Src Family Kinase Activity Is Required for Murine Embryonic Stem Cell Growth and Differentiation

Is Placebo Response Responsible for Many Phase III Failures?

Is Placebo Response Responsible for Many Phase III Failures?

Expression of various scinderin domains in chromaffin cells indicates that this protein acts as a molecular switch in the control of actin filament dynamics and exocytosis

Population Pharmacokinetics and Pharmacodynamics Modelling of Dilmapimod in Severe Trauma Subjects at Risk for Acute Respiratory Distress Syndrome

Phase IIa Proof-of-Concept Evaluation of the Antiviral Efficacy, Safety, Tolerability, and Pharmacokinetics of the Next-Generation Maturation Inhibitor GSK3640254

The FEAR Before MEN: Networks of Mitotic Exit

Pharmacometrics-guided drug development of antihyperhidrosis agents

Abstract 3687: Expression of a Src-family kinase in CML cells induces resistance to imatinib in a kinase-dependent manner

Abl N-Terminal Cap Stabilization of SH3 Domain Dynamics

HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck

Molecular Motors Involved in Chromaffin Cell Secretion

Investigating the Src kinase Hck functions in chronic myelogenous leukemia using chemical genetics methods

The role of different scinderin domains in the control of actin filament dynamics and regulated exocytosis

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