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Two common disease-associated TYK2 variants impact exon splicing and TYK2 dosage

PloS one, 2020-01, Vol.15 (1), p.e0225289-e0225289

2020

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IFNA2: The prototypic human alpha interferon

Gene, 2015-08, Vol.567 (2), p.132-137

2015

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STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling

Nature structural & molecular biology, 2017-03, Vol.24 (3), p.279-289

2017

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Assessment of mTOR-Dependent Translational Regulation of Interferon Stimulated Genes

PloS one, 2015-07, Vol.10 (7), p.e0133482-e0133482

2015

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Mycolactone subverts immunity by selectively blocking the Sec61 translocon

The Journal of experimental medicine, 2016-12, Vol.213 (13), p.2885-2896

2016

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ISG15 deficiency and increased viral resistance in humans but not mice

Nature communications, 2016-05, Vol.7 (1), p.11496-11496, Article 11496

2016

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USP18-based negative feedback control is induced by type I and type III interferons and specifically inactivates interferon α response

PloS one, 2011, Vol.6 (7), p.e22200-e22200

2011

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A partial form of inherited human USP18 deficiency underlies infection and inflammation

The Journal of experimental medicine, 2022-04, Vol.219 (4)

2022

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USP18 and ISG15 coordinately impact on SKP2 and cell cycle progression

Scientific reports, 2019-03, Vol.9 (1), p.4066-4066, Article 4066

2019

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Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling

The Journal of cell biology, 2015-05, Vol.209 (4), p.579-593

2015

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Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense

PLoS genetics, 2009-07, Vol.5 (7), p.e1000562-e1000562

2009

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IFN-I inducible miR-3614-5p targets ADAR1 isoforms and fine tunes innate immune activation

Frontiers in immunology, 2022-07, Vol.13, p.939907-939907

2022

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Two rare disease-associated Tyk2 variants are catalytically impaired but signaling competent

The Journal of immunology (1950), 2013-03, Vol.190 (5), p.2335-2344

2013

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Receptor Density Is Key to the Alpha2/Beta Interferon Differential Activities

Molecular and Cellular Biology, 2009-09, Vol.29 (17), p.4778-4787

2009

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Type I Interferonopathy due to a Homozygous Loss-of-Inhibitory Function Mutation in STAT2

Journal of clinical immunology, 2023-05, Vol.43 (4), p.808-818

2023

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Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses

Cell reports (Cambridge), 2016-09, Vol.16 (10), p.2777-2791

2016

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Genome-wide expression profiling of lymphoblastoid cell lines distinguishes different forms of autism and reveals shared pathways

Human molecular genetics, 2007-07, Vol.16 (14), p.1682-1698

2007

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Human Ubiquitin-Specific Peptidase 18 Is Regulated by microRNAs via the 3'Untranslated Region, A Sequence Duplicated in Long Intergenic Non-coding RNA Genes Residing in chr22q11.21

Frontiers in genetics, 2021-02, Vol.11, p.627007-627007

2021

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Tyk2 and Stat3 Regulate Brown Adipose Tissue Differentiation and Obesity

Cell metabolism, 2012-12, Vol.16 (6), p.814-824

2012

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Altered Immune Phenotypes and HLA-DQB1 Gene Variation in Multiple Sclerosis Patients Failing Interferon β Treatment

Frontiers in immunology, 2021-05, Vol.12, p.628375-628375

2021

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Copy number variations and founder effect underlying complete IL-10Rβ deficiency in Portuguese kindreds

PloS one, 2018-10, Vol.13 (10), p.e0205826-e0205826

2018

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Genome-Wide Gene Expression Analysis of Mtb-Infected DC Highlights the Rapamycin-Driven Modulation of Regulatory Cytokines via the mTOR/GSK-3β Axis

Frontiers in immunology, 2021-04, Vol.12, p.649475-649475

2021

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T cell receptor signal initiation induced by low-grade stimulation requires the cooperation of LAT in human T cells

PloS one, 2010-11, Vol.5 (11), p.e15114-e15114

2010

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Biochemical monitoring of the early endocytic traffic of the type I interferon receptor

Journal of interferon & cytokine research, 2010-02, Vol.30 (2), p.89-98

2010

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A Natural Mutation in the Tyk2 Pseudokinase Domain Underlies Altered Susceptibility of B10.Q/J Mice to Infection and Autoimmunity

Proceedings of the National Academy of Sciences - PNAS, 2003-09, Vol.100 (20), p.11594-11599

2003

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Two common disease-associated TYK2 variants impact exon splicing and TYK2 dosage

IFNA2: The prototypic human alpha interferon

STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling

Assessment of mTOR-Dependent Translational Regulation of Interferon Stimulated Genes

Mycolactone subverts immunity by selectively blocking the Sec61 translocon

ISG15 deficiency and increased viral resistance in humans but not mice

USP18-based negative feedback control is induced by type I and type III interferons and specifically inactivates interferon α response

A partial form of inherited human USP18 deficiency underlies infection and inflammation

USP18 and ISG15 coordinately impact on SKP2 and cell cycle progression

Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling

Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense

IFN-I inducible miR-3614-5p targets ADAR1 isoforms and fine tunes innate immune activation

Two rare disease-associated Tyk2 variants are catalytically impaired but signaling competent

Receptor Density Is Key to the Alpha2/Beta Interferon Differential Activities

Type I Interferonopathy due to a Homozygous Loss-of-Inhibitory Function Mutation in STAT2

Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses

Genome-wide expression profiling of lymphoblastoid cell lines distinguishes different forms of autism and reveals shared pathways

Human Ubiquitin-Specific Peptidase 18 Is Regulated by microRNAs via the 3'Untranslated Region, A Sequence Duplicated in Long Intergenic Non-coding RNA Genes Residing in chr22q11.21

Tyk2 and Stat3 Regulate Brown Adipose Tissue Differentiation and Obesity

Altered Immune Phenotypes and HLA-DQB1 Gene Variation in Multiple Sclerosis Patients Failing Interferon β Treatment

Copy number variations and founder effect underlying complete IL-10Rβ deficiency in Portuguese kindreds

Genome-Wide Gene Expression Analysis of Mtb-Infected DC Highlights the Rapamycin-Driven Modulation of Regulatory Cytokines via the mTOR/GSK-3β Axis

T cell receptor signal initiation induced by low-grade stimulation requires the cooperation of LAT in human T cells

Biochemical monitoring of the early endocytic traffic of the type I interferon receptor

A Natural Mutation in the Tyk2 Pseudokinase Domain Underlies Altered Susceptibility of B10.Q/J Mice to Infection and Autoimmunity

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