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Building a toxicokinetic model using in vitro/in silico data: What is needed?

Toxicology letters, 2015-10, Vol.238 (2), p.S47-S47

Pelkonen, O.

2015

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Human placenta: a human organ for developmental toxicology research and biomonitoring

Placenta (Eastbourne), 2005-05, Vol.26 (5), p.361-371

2005

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In vitro-in vivo extrapolation of hepatic clearance: Biological tools, scaling factors, model assumptions and correct concentrations

Xenobiotica, 2007-10, Vol.37 (10-11), p.1066-1089

2007

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Predictive value of animal models for human cytochrome P450 (CYP)-mediated metabolism: A comparative study in vitro

Xenobiotica, 2007-12, Vol.37 (12), p.1367-1377

2007

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Effect of Clopidogrel and Ticlopidine on Cytochrome P450 2B6 Activity as Measured by Bupropion Hydroxylation

Clinical pharmacology and therapeutics, 2005-06, Vol.77 (6), p.553-559

2005

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Reactive metabolites: In vitro screening techniques and potential extrapolation to in vivo

Toxicology letters, 2015-10, Vol.238 (2), p.S18-S18

Pelkonen, O.

2015

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Inhibition and induction of human cytochrome P450 (CYP) enzymes

Xenobiotica, 1998, Vol.28 (12), p.1203-1253

1998

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Toxicology of Herbal Products

1, 2017

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New potent and selective cytochrome P450 2B6 (CYP2B6) inhibitors based on three‐dimensional quantitative structure‐activity relationship (3D‐QSAR) analysis

British journal of pharmacology, 2007-04, Vol.150 (7), p.932-942

2007

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Rapid screening of commercially available herbal products for the inhibition of major human hepatic cytochrome P450 enzymes using the N-in-one cocktail

Xenobiotica, 2010-04, Vol.40 (4), p.245-254

2010

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P19-64 Relevance of dog studies for the derivation of health-based guidance values for plant protection products approval

Toxicology letters, 2024-09, Vol.399, p.S279-S279

2024

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Extracranial internal carotid and vertebral artery dissections: angiographic spectrum, course and prognosis

Neuroradiology, 2003-02, Vol.45 (2), p.71-77

2003

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Metabolism: a bottleneck in in vitro toxicological test development. The report and recommendations of ECVAM workshop 54

Alternatives to laboratory animals, 2006-02, Vol.34 (1), p.49-84

2006

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In vitro inhibition of cytochrome P450 enzymes in human liver microsomes by a potent CYP2A6 inhibitor, trans-2-phenylcyclopropylamine (tranylcypromine), and its nonamine analog, cyclopropylbenzene

Drug metabolism and disposition, 2001-03, Vol.29 (3), p.217

2001

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The expression of cytochrome P450 enzymes in human breast tumours and normal breast tissue

Breast cancer research and treatment, 2001-11, Vol.70 (1), p.47-54

2001

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Xenobiotic-Metabolizing Cytochrome P450 Enzymes in the Human Feto-Placental Unit: Role in Intrauterine Toxicity

Critical reviews in toxicology, 1998, Vol.28 (1), p.35-72

1998

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Cardiac arrest after interscalene brachial plexus block with ropivacaine and lidocaine

Acta anaesthesiologica Scandinavica, 2003-08, Vol.47 (7), p.904-906

2003

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Metabolic Activation of Toxins: Tissue-Specific Expression and Metabolism in Target Organs

Environmental health perspectives, 1997-06, Vol.105 (Suppl 4), p.767-774

1997

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In vitro inhibition screening of human hepatic P450 enzymes by five angiotensin-II receptor antagonists

European journal of clinical pharmacology, 2000-05, Vol.56 (2), p.135-140

2000

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Diagnosis of polymorphisms in carcinogen-activating and inactivating enzymes and cancer susceptibility-a review

Gene, 1995-06, Vol.159 (1), p.113-121

1995

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In vitro inhibition screening of human hepatic P 450 enzymes by five angiotensin-II receptor antagonists

European journal of clinical pharmacology, 2000-05, Vol.56 (2), p.135-140

2000

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The inhibition of major human hepatic cytochrome P450 enzymes by 18 pesticides: Comparison of the N-in-one and single substrate approaches

Toxicology in vitro, 2013-08, Vol.27 (5), p.1584-1588

2013

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Cerebral CT and MRI Findings in Cervicocephalic Artery Dissection

Acta radiologica (1987), 2004-05, Vol.45 (3), p.259-265

2004

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Cytochrome P450 Induction and Xeno‐Sensing Receptors Pregnane X Receptor, Constitutive Androstane Receptor, Aryl Hydrocarbon Receptor and Peroxisome Proliferator‐Activated Receptor α at the Crossroads of Toxicokinetics and Toxicodynamics

Basic & clinical pharmacology & toxicology, 2018-09, Vol.123 (S5), p.42-50

2018

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Validation of in vitro methods for human cytochrome P450 enzyme induction: Outcome of a multi-laboratory study

Toxicology in vitro, 2019-10, Vol.60, p.212-228

2019

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Building a toxicokinetic model using in vitro/in silico data: What is needed?

Human placenta: a human organ for developmental toxicology research and biomonitoring

In vitro-in vivo extrapolation of hepatic clearance: Biological tools, scaling factors, model assumptions and correct concentrations

Predictive value of animal models for human cytochrome P450 (CYP)-mediated metabolism: A comparative study in vitro

Effect of Clopidogrel and Ticlopidine on Cytochrome P450 2B6 Activity as Measured by Bupropion Hydroxylation

Reactive metabolites: In vitro screening techniques and potential extrapolation to in vivo

Inhibition and induction of human cytochrome P450 (CYP) enzymes

Toxicology of Herbal Products

New potent and selective cytochrome P450 2B6 (CYP2B6) inhibitors based on three‐dimensional quantitative structure‐activity relationship (3D‐QSAR) analysis

Rapid screening of commercially available herbal products for the inhibition of major human hepatic cytochrome P450 enzymes using the N-in-one cocktail

P19-64 Relevance of dog studies for the derivation of health-based guidance values for plant protection products approval

Extracranial internal carotid and vertebral artery dissections: angiographic spectrum, course and prognosis

Metabolism: a bottleneck in in vitro toxicological test development. The report and recommendations of ECVAM workshop 54

In vitro inhibition of cytochrome P450 enzymes in human liver microsomes by a potent CYP2A6 inhibitor, trans-2-phenylcyclopropylamine (tranylcypromine), and its nonamine analog, cyclopropylbenzene

The expression of cytochrome P450 enzymes in human breast tumours and normal breast tissue

Xenobiotic-Metabolizing Cytochrome P450 Enzymes in the Human Feto-Placental Unit: Role in Intrauterine Toxicity

Cardiac arrest after interscalene brachial plexus block with ropivacaine and lidocaine

Metabolic Activation of Toxins: Tissue-Specific Expression and Metabolism in Target Organs

In vitro inhibition screening of human hepatic P450 enzymes by five angiotensin-II receptor antagonists

Diagnosis of polymorphisms in carcinogen-activating and inactivating enzymes and cancer susceptibility-a review

In vitro inhibition screening of human hepatic P 450 enzymes by five angiotensin-II receptor antagonists

The inhibition of major human hepatic cytochrome P450 enzymes by 18 pesticides: Comparison of the N-in-one and single substrate approaches

Cerebral CT and MRI Findings in Cervicocephalic Artery Dissection

Cytochrome P450 Induction and Xeno‐Sensing Receptors Pregnane X Receptor, Constitutive Androstane Receptor, Aryl Hydrocarbon Receptor and Peroxisome Proliferator‐Activated Receptor α at the Crossroads of Toxicokinetics and Toxicodynamics

Validation of in vitro methods for human cytochrome P450 enzyme induction: Outcome of a multi-laboratory study

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