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Identification of a Putative Binding Site for [2‘,5‘-Bis-O-(tert-butyldimethylsilyl)-β-d-ribofuranosyl]-3‘-spiro-5‘ ‘-(4‘ ‘-amino-1‘ ‘,2‘ ‘-oxathiole-2‘ ‘,2‘ ‘-dioxide)thymine (TSAO) Derivatives at the p51−p66 Interface of HIV-1 Reverse Transcriptase

Journal of medicinal chemistry, 2001-06, Vol.44 (12), p.1853-1865

2001

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Highly favorable antiviral activity and resistance profile of the novel thiocarboxanilide pentenyloxy ether derivatives UC-781 and UC-82 as inhibitors of human immunodeficiency virus type 1 replication

Molecular pharmacology, 1996-08, Vol.50 (2), p.394-401

1996

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Characteristics of the Pro225His mutation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase that appears under selective pressure of dose-escalating quinoxaline treatment of HIV-1

Journal of Virology, 1997-11, Vol.71 (11), p.8195-8203

1997

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Reverse transcriptase fidelity and HIV-1 variation

Science (American Association for the Advancement of Science), 1997-01, Vol.275 (5297), p.229; author reply 230-229

1997

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Mutational Analysis of Trp-229 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase (RT) Identifies This Amino Acid Residue as a Prime Target for the Rational Design of New Non-Nucleoside RT Inhibitors

Molecular pharmacology, 2000-05, Vol.57 (5), p.954

2000

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Zidovudine-Resistant Human Immunodeficiency Virus Type 1 Strains Subcultured in the Presence of Both Lamivudine and Quinoxaline HBY 097 Retain Marked Sensitivity to HBY 097 but Not to Lamivudine

The Journal of infectious diseases, 1997-11, Vol.176 (5), p.1392-1397

1997

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Marked inhibitory activity of non-nucleoside reverse transcriptase inhibitors against human immunodeficiency virus type 1 when combined with (-)2',3'-dideoxy-3'-thiacytidine

Molecular pharmacology, 1996-05, Vol.49 (5), p.882-890

1996

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Identification and characterization of a Rhizobium leguminosarum bv. phaseoli gene that is important for nodulation competitiveness and shows structural homology to a Rhizobium fredii host-inducible gene

Molecular plant-microbe interactions, 1995-05, Vol.8 (3), p.468

1995

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Presence of 2', 5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5-(4-amino-1, 2-oxathiole-2, 2 -dioxide) (TSAO)-resistant virus strains in TSAO-inexperienced HIV patients

AIDS research and human retroviruses, 2000-06, Vol.16 (9), p.825-833

2000

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Mutational Analysis of Tyr-318 within the Non-nucleoside Reverse Transcriptase Inhibitor Binding Pocket of Human Immunodeficiency Virus Type I Reverse Transcriptase

The Journal of biological chemistry, 1998-12, Vol.273 (51), p.34234-34239

1998

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Anti-HIV and Anti-HBV Activity and Resistance Profile of 2′,3′-Dideoxy-3′-Thiacytidine (3TC) and Its Arylphosphoramidate Derivative CF 1109

Biochemical and biophysical research communications, 1996-08, Vol.225 (2), p.363-369

1996

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Mutations at Amino Acid Positions 63, 189, and 396 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase (RT) Partially Restore the DNA Polymerase Activity of a TRP229TYR Mutant RT

Virology (New York, N.Y.), 2001-08, Vol.287 (1), p.143-150

2001

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Concomitant Combination Therapy for HIV Infection Preferable over Sequential Therapy with 3TC and Non-Nucleoside Reverse Transcriptase Inhibitors

Proceedings of the National Academy of Sciences - PNAS, 1996-11, Vol.93 (23), p.13152-13157

1996

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Site-Directed Mutagenesis of Human Immunodeficiency Virus Type 1 Reverse Transcriptase at Amino Acid Position 138

Virology (New York, N.Y.), 2001-02, Vol.280 (1), p.97-106

2001

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A novel mutation (F227L) arises in the reverse transcriptase of human immunodeficiency virus type 1 on dose-escalating treatment of HIV type 1-infected cell cultures with the nonnucleoside reverse transcriptase inhibitor thiocarboxanilide UC-781

AIDS research and human retroviruses, 1998-02, Vol.14 (3), p.255-260

1998

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Reverse Transcriptase Fidelity and HIV-1 Variation

Science (American Association for the Advancement of Science), 1997-01, Vol.275 (5297), p.228-231

1997

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A proline-to-histidine substitution at position 225 of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) sensitizes HIV-1 RT to BHAP U-90152

Journal of general virology, 1998-06, Vol.79 (6), p.1347-1352

1998

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Retention of marked sensitivity to ( S)-4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3,4-Dihydroquinoxaline-2(1H)-Thione (HBY 097) by an azidothymidine (AZT)-resistant human immunodeficiency virus type 1 (HIV-1) strain subcultured in the combined presence of quinoxaline HBY 097 and 2′,3′-dideoxy-3′-thiacytidine (Lamivudine)

Biochemical pharmacology, 1998-03, Vol.55 (5), p.617-625

1998

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Retention of marked sensitivity to (S)-4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3,4-di hydroquin oxaline-2(1H)-thione (HBY 097) by an azidothymidine (AZT)-resistant human immunodeficiency virus type 1 (HIV-1) strain subcultured in the combined presence of quinoxaline HBY 097 and 2',3'-dideoxy-3'-thiacytidine (lamivudine)

Biochemical pharmacology, 1998-03, Vol.55 (5), p.617

1998

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Characterization of the Rhizobium leguminosarum biovar phaseoli nifA gene, a positive regulator of nif gene expression

Archives of microbiology, 1994, Vol.161 (5), p.404-408

1994

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Reverse transcriptase fidelity and HIV-1 variation

Science (American Association for the Advancement of Science), 1997-01, Vol.275 (5297), p.229

1997

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Concomitant combination therapy for HIV infection preferable over sequential therapy with 3TC and non-nucleoside reverse transcriptase inhibitors

Proceedings of the National Academy of Sciences - PNAS, 1996-01, Vol.93 (24), p.13152-13157

1996

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The combined presence of the quinoxaline HBY097 and 3TC results in potent suppression of AZT-resistant HIV-1 strains

Antiviral research, 1997-04, Vol.34 (2), p.A58-A58

1997

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Reverse transcriptase fidelity and HIV-1 variation. Reply

Science (American Association for the Advancement of Science), 1997, Vol.275 (5297), p.228-231

1997

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Vitamin D status in the elderly: seasonal substrate deficiency causes 1,25-dihydroxycholecalciferol deficiency

The American journal of clinical nutrition, 1987-04, Vol.45 (4), p.755-763

1987

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Identification of a Putative Binding Site for [2‘,5‘-Bis-O-(tert-butyldimethylsilyl)-β-d-ribofuranosyl]-3‘-spiro-5‘ ‘-(4‘ ‘-amino-1‘ ‘,2‘ ‘-oxathiole-2‘ ‘,2‘ ‘-dioxide)thymine (TSAO) Derivatives at the p51−p66 Interface of HIV-1 Reverse Transcriptase

Highly favorable antiviral activity and resistance profile of the novel thiocarboxanilide pentenyloxy ether derivatives UC-781 and UC-82 as inhibitors of human immunodeficiency virus type 1 replication

Characteristics of the Pro225His mutation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase that appears under selective pressure of dose-escalating quinoxaline treatment of HIV-1

Reverse transcriptase fidelity and HIV-1 variation

Mutational Analysis of Trp-229 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase (RT) Identifies This Amino Acid Residue as a Prime Target for the Rational Design of New Non-Nucleoside RT Inhibitors

Zidovudine-Resistant Human Immunodeficiency Virus Type 1 Strains Subcultured in the Presence of Both Lamivudine and Quinoxaline HBY 097 Retain Marked Sensitivity to HBY 097 but Not to Lamivudine

Marked inhibitory activity of non-nucleoside reverse transcriptase inhibitors against human immunodeficiency virus type 1 when combined with (-)2',3'-dideoxy-3'-thiacytidine

Identification and characterization of a Rhizobium leguminosarum bv. phaseoli gene that is important for nodulation competitiveness and shows structural homology to a Rhizobium fredii host-inducible gene

Presence of 2', 5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5-(4-amino-1, 2-oxathiole-2, 2 -dioxide) (TSAO)-resistant virus strains in TSAO-inexperienced HIV patients

Mutational Analysis of Tyr-318 within the Non-nucleoside Reverse Transcriptase Inhibitor Binding Pocket of Human Immunodeficiency Virus Type I Reverse Transcriptase

Anti-HIV and Anti-HBV Activity and Resistance Profile of 2′,3′-Dideoxy-3′-Thiacytidine (3TC) and Its Arylphosphoramidate Derivative CF 1109

Mutations at Amino Acid Positions 63, 189, and 396 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase (RT) Partially Restore the DNA Polymerase Activity of a TRP229TYR Mutant RT

Concomitant Combination Therapy for HIV Infection Preferable over Sequential Therapy with 3TC and Non-Nucleoside Reverse Transcriptase Inhibitors

Site-Directed Mutagenesis of Human Immunodeficiency Virus Type 1 Reverse Transcriptase at Amino Acid Position 138

A novel mutation (F227L) arises in the reverse transcriptase of human immunodeficiency virus type 1 on dose-escalating treatment of HIV type 1-infected cell cultures with the nonnucleoside reverse transcriptase inhibitor thiocarboxanilide UC-781

Reverse Transcriptase Fidelity and HIV-1 Variation

A proline-to-histidine substitution at position 225 of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) sensitizes HIV-1 RT to BHAP U-90152

Characterization of the Rhizobium leguminosarum biovar phaseoli nifA gene, a positive regulator of nif gene expression

Reverse transcriptase fidelity and HIV-1 variation

Concomitant combination therapy for HIV infection preferable over sequential therapy with 3TC and non-nucleoside reverse transcriptase inhibitors

The combined presence of the quinoxaline HBY097 and 3TC results in potent suppression of AZT-resistant HIV-1 strains

Reverse transcriptase fidelity and HIV-1 variation. Reply

Vitamin D status in the elderly: seasonal substrate deficiency causes 1,25-dihydroxycholecalciferol deficiency

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