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Lectin chaperones help direct the maturation of glycoproteins in the endoplasmic reticulum

Biochimica et biophysica acta, 2010-06, Vol.1803 (6), p.684-693

2010

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The Cotranslational Maturation Program for the Type II Membrane Glycoprotein Influenza Neuraminidase

The Journal of biological chemistry, 2008-12, Vol.283 (49), p.33826-33837

2008

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cell-based reglucosylation assay demonstrates the role of GT1 in the quality control of a maturing glycoprotein

The Journal of cell biology, 2008-04, Vol.181 (2), p.309-320

2008

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role of UDP-Glc:glycoprotein glucosyltransferase 1 in the maturation of an obligate substrate prosaposin

The Journal of cell biology, 2010-05, Vol.189 (5), p.829-841

2010

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Cotranslocational Degradation: Utilitarianism in the ER Stress Response

Molecular cell, 2006-09, Vol.23 (6), p.773-775

2006

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Yos9p: A Sweet-Toothed Bouncer of the Secretory Pathway

Molecular cell, 2005-09, Vol.19 (6), p.717-719

2005

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Single Agent CD45-Targeted Antibody Drug Conjugate Enables Full Mismatch Allogeneic Hematopoietic Stem Cell Transplantation in a Murine HSCT Model

Blood, 2020-11, Vol.136 (Supplement 1), p.31-31

2020

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A CD117-Amanitin Antibody Drug Conjugate (ADC) Effectively Depletes Human and Non-Human Primate Hematopoietic Stem and Progenitor Cells (HSPCs): targeted Non-Genotoxic Conditioning for Bone Marrow Transplant

Biology of blood and marrow transplantation, 2019-03, Vol.25 (3), p.S29-S30

2019

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Antibody Drug Conjugates Targeted to CD45 or CD117 Enable Allogeneic Hematopoietic Stem Cell Transplantation in Animal Models

Blood, 2018-11, Vol.132 (Supplement 1), p.3324-3324

2018

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A Single Dose of CD117 Antibody Drug Conjugate Enables Autologous Gene-Modified Hematopoietic Stem Cell Transplant (Gene Therapy) in Nonhuman Primates

Blood, 2019-11, Vol.134 (Supplement_1), p.610-610

2019

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Non-Genotoxic Conditioning for Hematopoietic Stem Cell Transplant Using a Human Antibody Drug Conjugate Targeting C-KIT

Blood, 2017-12, Vol.130, p.1894-1894

2017

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Single Doses of Antibody Drug Conjugates (ADCs) Targeted to CD117 or CD45 Have Potent In Vivo Anti-Leukemia Activity and Survival Benefit in Patient Derived AML Models

Blood, 2018-11, Vol.132 (Supplement 1), p.3316-3316

2018

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Targeting CD45 with an Amanitin Antibody-Drug Conjugate Effectively Depletes Human HSCs and Immune Cells for Transplant Conditioning

Blood, 2018-11, Vol.132 (Supplement 1), p.4526-4526

2018

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CD117-Amanitin Antibody Drug Conjugates Effectively Deplete Human and Non-Human Primate HSCs: Proof of Concept As a Targeted Strategy for Conditioning Patients for Bone Marrow Transplant

Blood, 2018-11, Vol.132 (Supplement 1), p.3314-3314

2018

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Targeted CD45 Antibody Drug Conjugate Enables Full Mismatch Allogeneic Hematopoietic Stem Cell Transplantation in a Murine HSCT Model As a Single Agent

Transplantation and cellular therapy, 2021-03, Vol.27 (3), p.S217

2021

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A Single Dose of a Novel Anti-Human CD117-Amanitin Antibody Drug Conjugate (ADC) Engineered for a Short Half-Life Provides Dual Conditioning and Anti-Leukemia Activity and Extends Survival Compared to Standard of Care in Multiple Preclinical Models of Acute Myeloid Leukemia (AML)

Transplantation and cellular therapy, 2021-03, Vol.27 (3), p.S49-S50

2021

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The Cotranslational Maturation Program for the Type II Membrane Glycoprotein Influenza NeuraminidaseS

The Journal of biological chemistry, 2008-12, Vol.283 (49), p.33826-33837

2008

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The ER glucosyltransferase reglucosylates non‐native and slow folding domains during glycoprotein maturation

The FASEB journal, 2006-03, Vol.20 (5), p.A915-A915

2006

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The role of UDP‐glucose: glycoprotein glucosyltransferase and EDEM in glycoprotein maturation and quality control in the ER

The FASEB journal, 2006-03, Vol.20 (5), p.A1307-A1307

2006

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Successful Allogeneic Hematopoietic Stem Cell Transplantation in Mice Mediated By Well-Tolerated Conditioning Regimens Based on CD45-Targeted Antibody Drug Conjugate: Implications for Haplo Transplantation

Biology of blood and marrow transplantation, 2020-03, Vol.26 (3), p.S160-S160

2020

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A Novel Targeted Approach to Achieve Immune System Reset: CD45-Targeted Antibody Drug Conjugates Enable Autologous HSCT and Ameliorate Disease in Preclinical Autoimmune Disease Models

Biology of blood and marrow transplantation, 2020-03, Vol.26 (3), p.S307-S308

2020

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A Non-Genotoxic Anti-CD117 Antibody Drug Conjugate (ADC) Designed for Patient Conditioning Prior to Stem Cell Transplant and HSC-Based Gene Therapy Has a Broad Therapeutic Window across Species

Biology of blood and marrow transplantation, 2020-03, Vol.26 (3), p.S35-S36

2020

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A Single Dose of CD117 Antibody Drug Conjugate Enables Hematopoietic Stem Cell Based Gene Therapy in Nonhuman Primates

Biology of blood and marrow transplantation, 2020-03, Vol.26 (3), p.S6-S6

2020

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Lectin chaperones help direct the maturation of glycoproteins in the endoplasmic reticulum

The Cotranslational Maturation Program for the Type II Membrane Glycoprotein Influenza Neuraminidase

cell-based reglucosylation assay demonstrates the role of GT1 in the quality control of a maturing glycoprotein

role of UDP-Glc:glycoprotein glucosyltransferase 1 in the maturation of an obligate substrate prosaposin

Cotranslocational Degradation: Utilitarianism in the ER Stress Response

Yos9p: A Sweet-Toothed Bouncer of the Secretory Pathway

A Single Dose of a Novel Anti-Human CD117-Amanitin Antibody Drug Conjugate (ADC) Engineered for a Short Half-Life Provides Dual Conditioning and Anti-Leukemic Activity and Extends Survival Compared to Standard of Care in Multiple Preclinical Models of Acute Myeloid Leukemia (AML)

Single Agent CD45-Targeted Antibody Drug Conjugate Enables Full Mismatch Allogeneic Hematopoietic Stem Cell Transplantation in a Murine HSCT Model

A CD117-Amanitin Antibody Drug Conjugate (ADC) Effectively Depletes Human and Non-Human Primate Hematopoietic Stem and Progenitor Cells (HSPCs): targeted Non-Genotoxic Conditioning for Bone Marrow Transplant

Antibody Drug Conjugates Targeted to CD45 or CD117 Enable Allogeneic Hematopoietic Stem Cell Transplantation in Animal Models

A Single Dose of CD117 Antibody Drug Conjugate Enables Autologous Gene-Modified Hematopoietic Stem Cell Transplant (Gene Therapy) in Nonhuman Primates

A Novel Targeted Approach to Achieve Immune System Reset: CD45-Targeted Antibody Drug Conjugates Enable Autologous HSCT, Ameliorate Disease in Autoimmune Models, Potently Kill Human Immune Cells from Normal Donors and MS Patients, and Achieve Immune Depletion in Non-Human Primates (NHP)

Non-Genotoxic Conditioning for Hematopoietic Stem Cell Transplant Using a Human Antibody Drug Conjugate Targeting C-KIT

Single Doses of Antibody Drug Conjugates (ADCs) Targeted to CD117 or CD45 Have Potent In Vivo Anti-Leukemia Activity and Survival Benefit in Patient Derived AML Models

Targeting CD45 with an Amanitin Antibody-Drug Conjugate Effectively Depletes Human HSCs and Immune Cells for Transplant Conditioning

CD117-Amanitin Antibody Drug Conjugates Effectively Deplete Human and Non-Human Primate HSCs: Proof of Concept As a Targeted Strategy for Conditioning Patients for Bone Marrow Transplant

Targeted CD45 Antibody Drug Conjugate Enables Full Mismatch Allogeneic Hematopoietic Stem Cell Transplantation in a Murine HSCT Model As a Single Agent

A Single Dose of a Novel Anti-Human CD117-Amanitin Antibody Drug Conjugate (ADC) Engineered for a Short Half-Life Provides Dual Conditioning and Anti-Leukemia Activity and Extends Survival Compared to Standard of Care in Multiple Preclinical Models of Acute Myeloid Leukemia (AML)

The Cotranslational Maturation Program for the Type II Membrane Glycoprotein Influenza NeuraminidaseS

The ER glucosyltransferase reglucosylates non‐native and slow folding domains during glycoprotein maturation

The role of UDP‐glucose: glycoprotein glucosyltransferase and EDEM in glycoprotein maturation and quality control in the ER

Successful Allogeneic Hematopoietic Stem Cell Transplantation in Mice Mediated By Well-Tolerated Conditioning Regimens Based on CD45-Targeted Antibody Drug Conjugate: Implications for Haplo Transplantation

A Novel Targeted Approach to Achieve Immune System Reset: CD45-Targeted Antibody Drug Conjugates Enable Autologous HSCT and Ameliorate Disease in Preclinical Autoimmune Disease Models

A Non-Genotoxic Anti-CD117 Antibody Drug Conjugate (ADC) Designed for Patient Conditioning Prior to Stem Cell Transplant and HSC-Based Gene Therapy Has a Broad Therapeutic Window across Species

A Single Dose of CD117 Antibody Drug Conjugate Enables Hematopoietic Stem Cell Based Gene Therapy in Nonhuman Primates

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