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Age‐ and Genotype‐Dependent Variability in the Protein Abundance and Activity of Six Major Uridine Diphosphate‐Glucuronosyltransferases in Human Liver

Clinical pharmacology and therapeutics, 2019-01, Vol.105 (1), p.131-141

2019

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Human carboxylesterases HCE1 and HCE2: Ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, aspirin, deltamethrin and permethrin

Biochemical pharmacology, 2009-01, Vol.77 (2), p.238-247

2009

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In Vitro Hepatic Oxidative Biotransformation of Trimethoprim

Drug metabolism and disposition, 2015-09, Vol.43 (9), p.1372-1380

2015

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Influence of novel CYP2C‐haplotype on proton pump inhibitor pharmacokinetics in children

Clinical and translational science, 2024-04, Vol.17 (4), p.e13782-n/a

2024

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The role of human cytochrome P450 enzymes in the formation of 2-hydroxymetronidazole: CYP2A6 is the high affinity (low Km) catalyst

Drug metabolism and disposition, 2013-09, Vol.41 (9), p.1686-1694

2013

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A longitudinal study of cytochrome P450 2D6 (CYP2D6) activity during adolescence

Clinical and translational science, 2022-10, Vol.15 (10), p.2514-2527

2022

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Variability in Expression of CYP3A5 in Human Fetal Liver

Drug metabolism and disposition, 2015-08, Vol.43 (8), p.1286-1293

2015

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Utility of the 13C‐pantoprazole breath test as a CYP2C19 phenotyping probe for children

Clinical and translational science, 2022-05, Vol.15 (5), p.1155-1166

2022

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Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine

Drug metabolism and disposition, 2008-08, Vol.36 (8), p.1637-1649

2008

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Variability of CYP3A7 expression in human fetal liver

The Journal of pharmacology and experimental therapeutics, 2005-08, Vol.314 (2), p.626-635

2005

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CYP3A4-Mediated carbamazepine (CBZ) metabolism: formation of a covalent CBZ-CYP3A4 adduct and alteration of the enzyme kinetic profile

Drug metabolism and disposition, 2008-03, Vol.36 (3), p.490-499

2008

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Age‐Dependent Abundance of CYP450 Enzymes Involved in Metronidazole Metabolism: Application to Pediatric PBPK Modeling

Clinical pharmacology and therapeutics, 2024-10, Vol.116 (4), p.1090-1099

2024

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Ontogeny of Scaling Factors for Pediatric Physiologically Based Pharmacokinetic Modeling and Simulation: Cytosolic Protein Per Gram of Liver

Drug metabolism and disposition, 2023-12, Vol.51 (12), p.1578-1582

2023

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Pathways of carbamazepine bioactivation in vitro: II. The role of human cytochrome P450 enzymes in the formation of 2-hydroxyiminostilbene

Drug metabolism and disposition, 2005-12, Vol.33 (12), p.1819

2005

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Ontogeny of Hepatic Sulfotransferases and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism

Drug metabolism and disposition, 2019-08, Vol.47 (8), p.818-831

2019

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Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants

Drug metabolism and disposition, 2017-02, Vol.45 (2), p.216-223

2017

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The Impact of Age and Genetics on Naltrexone Biotransformation

Drug metabolism and disposition, 2022-02, Vol.50 (2), p.168-173

2022

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Age-dependent Protein Abundance of Cytosolic Alcohol and Aldehyde Dehydrogenases in Human Liver

Drug metabolism and disposition, 2017-09, Vol.45 (9), p.1044-1048

2017

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Biotransformation of fluticasone: in vitro characterization

Drug metabolism and disposition, 2006-06, Vol.34 (6), p.1035-1040

2006

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Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants

Drug metabolism and disposition, 2017-02, Vol.45 (2), p.216-223

2017

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Ontogeny of Scaling Factors for Pediatric Physiology-Based Pharmacokinetic Modeling and Simulation: Microsomal Protein Per Gram of Liver

Drug metabolism and disposition, 2022-01, Vol.50 (1), p.24-32

2022

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Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites

Drug metabolism and disposition, 2002-11, Vol.30 (11), p.1170-1179

2002

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Discovery of the nonfunctional CYP2D631 allele in Spanish, Puerto Rican, and US Hispanic populations

European journal of clinical pharmacology, 2010-09, Vol.66 (9), p.859-864

2010

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Development of a UPLC-MS/MS method for quantitation of metronidazole and 2-hydroxy metronidazole in human plasma and its application to a pharmacokinetic study

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2018-08, Vol.1092, p.272-278

2018

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The Impact of the CYP2D6 “Enhancer” Single Nucleotide Polymorphism on CYP2D6 Activity

Clinical pharmacology and therapeutics, 2022-03, Vol.111 (3), p.646-654

2022

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Age‐ and Genotype‐Dependent Variability in the Protein Abundance and Activity of Six Major Uridine Diphosphate‐Glucuronosyltransferases in Human Liver

Human carboxylesterases HCE1 and HCE2: Ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, aspirin, deltamethrin and permethrin

In Vitro Hepatic Oxidative Biotransformation of Trimethoprim

Influence of novel CYP2C‐haplotype on proton pump inhibitor pharmacokinetics in children

The role of human cytochrome P450 enzymes in the formation of 2-hydroxymetronidazole: CYP2A6 is the high affinity (low Km) catalyst

A longitudinal study of cytochrome P450 2D6 (CYP2D6) activity during adolescence

Variability in Expression of CYP3A5 in Human Fetal Liver

Utility of the 13C‐pantoprazole breath test as a CYP2C19 phenotyping probe for children

Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine

Variability of CYP3A7 expression in human fetal liver

CYP3A4-Mediated carbamazepine (CBZ) metabolism: formation of a covalent CBZ-CYP3A4 adduct and alteration of the enzyme kinetic profile

Age‐Dependent Abundance of CYP450 Enzymes Involved in Metronidazole Metabolism: Application to Pediatric PBPK Modeling

Ontogeny of Scaling Factors for Pediatric Physiologically Based Pharmacokinetic Modeling and Simulation: Cytosolic Protein Per Gram of Liver

Pathways of carbamazepine bioactivation in vitro: II. The role of human cytochrome P450 enzymes in the formation of 2-hydroxyiminostilbene

Ontogeny of Hepatic Sulfotransferases and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism

Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants

The Impact of Age and Genetics on Naltrexone Biotransformation

Age-dependent Protein Abundance of Cytosolic Alcohol and Aldehyde Dehydrogenases in Human Liver

Biotransformation of fluticasone: in vitro characterization

Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants

Ontogeny of Scaling Factors for Pediatric Physiology-Based Pharmacokinetic Modeling and Simulation: Microsomal Protein Per Gram of Liver

Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites

Discovery of the nonfunctional CYP2D631 allele in Spanish, Puerto Rican, and US Hispanic populations

Development of a UPLC-MS/MS method for quantitation of metronidazole and 2-hydroxy metronidazole in human plasma and its application to a pharmacokinetic study

The Impact of the CYP2D6 “Enhancer” Single Nucleotide Polymorphism on CYP2D6 Activity

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