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Design and synthesis of dihydroisoquinolones for fragment-based drug discovery (FBDD)

Organic & biomolecular chemistry, 2016-02, Vol.14 (5), p.1599-1610

2016

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Atropisomeric Racemization Kinetics of MRTX1719 Using Chiral Solvating Agent-Assisted 19F NMR Spectroscopy

ACS omega, 2022-09, Vol.7 (36), p.32062-32067

2022

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Isolation and Structural Proof of the Large Diamond Molecule, Cyclohexamantane (C26H30)

Angewandte Chemie (International ed.), 2003-05, Vol.42 (18), p.2040-2044

2003

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The Molecular Fossil Record of Oleanane and Its Relation to Angiosperms

Science (American Association for the Advancement of Science), 1994-08, Vol.265 (5173), p.768-771

1994

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Preparation of triazolobenzodiazepine derivatives as Vasopressin V1a antagonists

Tetrahedron letters, 2011-11, Vol.52 (45), p.5913-5917

2011

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Cyclization of the Acyl Glucuronide Metabolite of a Neutral Endopeptidase Inhibitor to an Electrophilic Glutarimide: Synthesis, Reactivity, and Mechanistic Analysis

Journal of medicinal chemistry, 2007-11, Vol.50 (24), p.6165-6176

2007

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A highly selective method for 11 beta-OH protection of steroidal 11 beta, 17 alpha-diols

Steroids, 2008-05, Vol.73 (5), p.574-577

2008

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A highly selective method for 11β-OH protection of steroidal 11β, 17α-diols

Steroids, 2008-05, Vol.73 (5), p.574-577

2008

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Accuracy vs Time Dilemma on the Prediction of NMR Chemical Shifts: A Case Study (Chloropyrimidines)

Journal of organic chemistry, 2006-04, Vol.71 (8), p.3103-3110

2006

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X‑ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor

Journal of medicinal chemistry, 2022-09, Vol.65 (18), p.12319-12333

2022

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Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X‑Linked Inhibitor of Apoptosis Protein (XIAP)

Journal of medicinal chemistry, 2017-06, Vol.60 (11), p.4611-4625

2017

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Design and synthesis of dihydroisoquinolones for fragment-based drug discovery (FBDD)Electronic supplementary information (ESI) available. See DOI: 10.1039/c5ob02461g

2016-01

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Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase‑2 (SHP2)

Journal of medicinal chemistry, 2024-03, Vol.67 (6), p.4655-4675

2024

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Atropisomeric Racemization Kinetics of MRTX1719 Using Chiral Solvating Agent-Assisted 19 F NMR Spectroscopy

ACS omega, 2022-09, Vol.7 (36), p.32062-32067

2022

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Homoallyl-Substituted Vinylcyclopropanes from α,β-Unsaturated Ketones and Allylindium Derivatives

Angewandte Chemie (International ed.), 1998-06, Vol.37 (11), p.1545-1547

1998

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Entropy-Driven Hydrogen Bonding: Stereodynamics of a Protonated, N,N-Chiral "Proton Sponge"

Chemistry : a European journal, 2000-12, Vol.6 (24), p.4451-4460

2000

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Long‐chain alkenes of the haptophytes Isochrysis galbana and Emiliania huxleyi

Lipids, 1998-06, Vol.33 (6), p.617-625

1998

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Regioselective directed lithiation of N-Boc 3-hydroxypyrrolidine. Synthesis of 2-substituted 4-hydroxypyrrolidines

Chemical communications (Cambridge, England), 1998-08 (16), p.1723-1724

1998

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Aldehydes and ketones as dipolarophiles: application to the synthesis of oxapenams

Chemical communications (Cambridge, England), 1999-02 (3), p.249-250

1999

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Highly Substituted Homoallylvinylcyclopropanes by Indium-Mediated Reaction of α,β-Unsaturated Ketones and Aldehydes with Allylic Halides

European journal of organic chemistry, 2000-03, Vol.2000 (6), p.963-974

2000

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Design and synthesis of dihydroisoquinolones for fragment-based drug discovery (FBDD)

Structure–Activity and Structure–Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2‑Related Factor 2 (KEAP1/NRF2) Protein–Protein Interaction

Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2

Atropisomeric Racemization Kinetics of MRTX1719 Using Chiral Solvating Agent-Assisted 19F NMR Spectroscopy

Isolation and Structural Proof of the Large Diamond Molecule, Cyclohexamantane (C26H30)

The Molecular Fossil Record of Oleanane and Its Relation to Angiosperms

Preparation of triazolobenzodiazepine derivatives as Vasopressin V1a antagonists

Cyclization of the Acyl Glucuronide Metabolite of a Neutral Endopeptidase Inhibitor to an Electrophilic Glutarimide: Synthesis, Reactivity, and Mechanistic Analysis

A highly selective method for 11 beta-OH protection of steroidal 11 beta, 17 alpha-diols

A highly selective method for 11β-OH protection of steroidal 11β, 17α-diols

Accuracy vs Time Dilemma on the Prediction of NMR Chemical Shifts: A Case Study (Chloropyrimidines)

X‑ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor

Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X‑Linked Inhibitor of Apoptosis Protein (XIAP)

Design and synthesis of dihydroisoquinolones for fragment-based drug discovery (FBDD)Electronic supplementary information (ESI) available. See DOI: 10.1039/c5ob02461g

Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase‑2 (SHP2)

Fragment-Based Discovery of a Series of Allosteric-Binding Site Modulators of β‑Glucocerebrosidase

Atropisomeric Racemization Kinetics of MRTX1719 Using Chiral Solvating Agent-Assisted 19 F NMR Spectroscopy

Homoallyl-Substituted Vinylcyclopropanes from α,β-Unsaturated Ketones and Allylindium Derivatives

Entropy-Driven Hydrogen Bonding: Stereodynamics of a Protonated, N,N-Chiral "Proton Sponge"

Long‐chain alkenes of the haptophytes Isochrysis galbana and Emiliania huxleyi

Regioselective directed lithiation of N-Boc 3-hydroxypyrrolidine. Synthesis of 2-substituted 4-hydroxypyrrolidines

Aldehydes and ketones as dipolarophiles: application to the synthesis of oxapenams

Highly Substituted Homoallylvinylcyclopropanes by Indium-Mediated Reaction of α,β-Unsaturated Ketones and Aldehydes with Allylic Halides

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