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Small molecule therapeutics for tauopathy in Alzheimer’s disease: Walking on the path of most resistance

European journal of medicinal chemistry, 2021-01, Vol.209, p.112915-112915, Article 112915

2021

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amyloid β-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

Proceedings of the National Academy of Sciences - PNAS, 2008-09, Vol.105 (35), p.13145-13150

2008

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Mitochondrial dysfunction in a transgenic mouse model expressing human amyloid precursor protein (APP) with the Arctic mutation

Journal of neurochemistry, 2016-02, Vol.136 (3), p.497-502

2016

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Targeting Chaperone/Co-Chaperone Interactions with Small Molecules: A Novel Approach to Tackle Neurodegenerative Diseases

Cells (Basel, Switzerland), 2021-09, Vol.10 (10), p.2596

2021

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Structure-based discovery of small molecule inhibitors of FKBP51-Hsp90 protein-protein interaction

European journal of medicinal chemistry, 2024-04, Vol.270, p.116356-116356, Article 116356

2024

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Metal Binding by GMP-1 and Its Pyrimido [1, 2]benzimidazole Analogs Confirms Protection Against Amyloid-β Associated Neurotoxicity

Journal of Alzheimer's disease, 2020-01, Vol.73 (2), p.695

2020

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Combined x-ray crystallography and computational modeling approach to investigate the Hsp90 C-terminal peptide binding to FKBP51

Scientific reports, 2017-10, Vol.7 (1), p.14288-17, Article 14288

2017

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FKBP51-Hsp90 Interaction-Deficient Mice Exhibit Altered Endocrine Stress Response and Sex Differences Under High-Fat Diet

Molecular neurobiology, 2024-03, Vol.61 (3), p.1479-1494

2024

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Mitochondrial γ-secretase participates in the metabolism of mitochondria-associated amyloid precursor protein

The FASEB journal, 2011, Vol.25 (1), p.78-88

2011

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Studies of Chaperone-Cochaperone Interactions using Homogenous Bead-Based Assay

Journal of visualized experiments, 2021-07 (173)

2021

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Mitochondrial accumulation of APP and Aβ: significance for Alzheimer disease pathogenesis

Journal of cellular and molecular medicine, 2009-10, Vol.13 (10), p.4137-4145

2009

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Development of GMP‐1 a molecular chaperone network modulator protecting mitochondrial function and its assessment in fly and mice models of Alzheimer's disease

Journal of cellular and molecular medicine, 2018-07, Vol.22 (7), p.3464-3474

2018

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Degradation of the Amyloid β-Protein by the Novel Mitochondrial Peptidasome, PreP

The Journal of biological chemistry, 2006-09, Vol.281 (39), p.29096-29104

2006

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In silico identification and biochemical characterization of the human dicarboxylate clamp TPR protein interaction network

FEBS open bio, 2018-11, Vol.8 (11), p.1830-1843

2018

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Abnormal platelet amyloid-β protein precursor (AβPP) metabolism in Alzheimer's disease: identification and characterization of a new AβPP isoform as potential biomarker

Journal of Alzheimer's disease, 2013-01, Vol.35 (2), p.285

2013

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Association of Omi/HtrA2 with γ-secretase in mitochondria

Neurochemistry international, 2010-11, Vol.57 (6), p.668-675

2010

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Metabolism of mitochondria-associated APP

Alzheimer's & dementia, 2010-07, Vol.6 (4), p.S395-S395

Pavlov, Pavel F

2010

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P4-197: Regulation of HtrA2/Omi activity by the mitochondrial γ-secretase

Alzheimer's & dementia, 2008-07, Vol.4 (4), p.T729-T729

Pavlov, Pavel F

2008

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GMP‐1 and its analogues bind Cu 2+ and Zn 2+ and protect neurons against amyloid beta toxicity: Nonhuman/Lead optimization studies

Alzheimer's & dementia, 2020-12, Vol.16 (S9)

2020

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GMP‐1 and its analogues bind Cu2+ and Zn2+ and protect neurons against amyloid beta toxicity

Alzheimer's & dementia, 2020-12, Vol.16, p.n/a

2020

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THERAPEUTIC TARGETING OF FKBP51 CO-CHAPERONE FOR POTENTIAL ANTI-TAU THERAPY FOR ALZHEIMER’S DISEASE

Alzheimer's & dementia, 2019-07, Vol.15 (7), p.P1287-P1288

2019

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P4‐034: THERAPEUTIC TARGETING OF FKBP51 CO‐CHAPERONE FOR POTENTIAL ANTI‐TAU THERAPY FOR ALZHEIMER'S DISEASE

Alzheimer's & dementia, 2019-07, Vol.15 (7S_Part_24), p.P1287-P1288

2019

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Aged mice lacking interaction between FKBP51 and Hsp90 have normal cognition and memory

Alzheimer's & dementia, 2023-12, Vol.19 (S12)

2023

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Immunohistochemical and behavioral assessment of FKBP51‐Hsp90 interaction‐deficient mouse crossed with Alzheimer tau transgenic Tg4510 mice

Alzheimer's & dementia, 2023-12, Vol.19 (S21), p.n/a

2023

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FKBP51‐Hsp90 complex as a novel therapeutic target for Alzheimer’s disease: Nonhuman/Target identification and validation studies: Other

Alzheimer's & dementia, 2020-12, Vol.16 (S9)

2020

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Small molecule therapeutics for tauopathy in Alzheimer’s disease: Walking on the path of most resistance

amyloid β-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

Mitochondrial dysfunction in a transgenic mouse model expressing human amyloid precursor protein (APP) with the Arctic mutation

Targeting Chaperone/Co-Chaperone Interactions with Small Molecules: A Novel Approach to Tackle Neurodegenerative Diseases

Structure-based discovery of small molecule inhibitors of FKBP51-Hsp90 protein-protein interaction

Metal Binding by GMP-1 and Its Pyrimido [1, 2]benzimidazole Analogs Confirms Protection Against Amyloid-β Associated Neurotoxicity

Combined x-ray crystallography and computational modeling approach to investigate the Hsp90 C-terminal peptide binding to FKBP51

FKBP51-Hsp90 Interaction-Deficient Mice Exhibit Altered Endocrine Stress Response and Sex Differences Under High-Fat Diet

Mitochondrial γ-secretase participates in the metabolism of mitochondria-associated amyloid precursor protein

Studies of Chaperone-Cochaperone Interactions using Homogenous Bead-Based Assay

Mitochondrial accumulation of APP and Aβ: significance for Alzheimer disease pathogenesis

Development of GMP‐1 a molecular chaperone network modulator protecting mitochondrial function and its assessment in fly and mice models of Alzheimer's disease

Degradation of the Amyloid β-Protein by the Novel Mitochondrial Peptidasome, PreP

In silico identification and biochemical characterization of the human dicarboxylate clamp TPR protein interaction network

Abnormal platelet amyloid-β protein precursor (AβPP) metabolism in Alzheimer's disease: identification and characterization of a new AβPP isoform as potential biomarker

Association of Omi/HtrA2 with γ-secretase in mitochondria

Metabolism of mitochondria-associated APP

P4-197: Regulation of HtrA2/Omi activity by the mitochondrial γ-secretase

GMP‐1 and its analogues bind Cu 2+ and Zn 2+ and protect neurons against amyloid beta toxicity: Nonhuman/Lead optimization studies

GMP‐1 and its analogues bind Cu2+ and Zn2+ and protect neurons against amyloid beta toxicity

THERAPEUTIC TARGETING OF FKBP51 CO-CHAPERONE FOR POTENTIAL ANTI-TAU THERAPY FOR ALZHEIMER’S DISEASE

P4‐034: THERAPEUTIC TARGETING OF FKBP51 CO‐CHAPERONE FOR POTENTIAL ANTI‐TAU THERAPY FOR ALZHEIMER'S DISEASE

Aged mice lacking interaction between FKBP51 and Hsp90 have normal cognition and memory

Immunohistochemical and behavioral assessment of FKBP51‐Hsp90 interaction‐deficient mouse crossed with Alzheimer tau transgenic Tg4510 mice

FKBP51‐Hsp90 complex as a novel therapeutic target for Alzheimer’s disease: Nonhuman/Target identification and validation studies: Other

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