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Antibiotic thermorubin tethers ribosomal subunits and impedes A-site interactions to perturb protein synthesis in bacteria

Nature communications, 2023-02, Vol.14 (1), p.918-918, Article 918

2023

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Mechanistic insights into translation inhibition by aminoglycoside antibiotic arbekacin

Nucleic acids research, 2021-07, Vol.49 (12), p.6880-6892

2021

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Optimal control of gene expression for fast proteome adaptation to environmental change

Proceedings of the National Academy of Sciences - PNAS, 2013-12, Vol.110 (51), p.20527-20532

2013

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Slow peptide bond formation by proline and other N-alkylamino acids in translation

Proceedings of the National Academy of Sciences - PNAS, 2009-01, Vol.106 (1), p.50-54

2009

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On the pH Dependence of Class-1 RF-Dependent Termination of mRNA Translation

Journal of molecular biology, 2015-05, Vol.427 (9), p.1848-1860

2015

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pH-sensitivity of the ribosomal peptidyl transfer reaction dependent on the identity of the A-site aminoacyl-tRNA

Proceedings of the National Academy of Sciences - PNAS, 2011-01, Vol.108 (1), p.79-84

2011

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How initiation factors tune the rate of initiation of protein synthesis in bacteria

The EMBO journal, 2006-06, Vol.25 (11), p.2539-2550

2006

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How Initiation Factors Maximize the Accuracy of tRNA Selection in Initiation of Bacterial Protein Synthesis

Molecular cell, 2006-07, Vol.23 (2), p.183-193

2006

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Estimation of peptide elongation times from ribosome profiling spectra

Nucleic acids research, 2021-05, Vol.49 (9), p.5124-5142

2021

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Complementary roles of initiation factor 1 and ribosome recycling factor in 70S ribosome splitting

The EMBO journal, 2008-06, Vol.27 (12), p.1706-1717

2008

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Peptide Formation by N‑Methyl Amino Acids in Translation Is Hastened by Higher pH and tRNAPro

ACS chemical biology, 2014-06, Vol.9 (6), p.1303-1311

2014

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Accuracy of genetic code translation and its orthogonal corruption by aminoglycosides and Mg2+ ions

Nucleic acids research, 2018-02, Vol.46 (3), p.1362-1374

2018

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Substrate-Induced Formation of Ribosomal Decoding Center for Accurate and Rapid Genetic Code Translation

Annual review of biophysics, 2018-05, Vol.47 (1), p.525-548

2018

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Dynamics of release factor recycling during translation termination in bacteria

Nucleic acids research, 2023-06, Vol.51 (11), p.5774-5790

2023

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Novel Roles for Classical Factors at the Interface between Translation Termination and Initiation

Molecular cell, 1999-05, Vol.3 (5), p.601-609

1999

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tmRNA·SmpB complex mimics native aminoacyl-tRNAs in the A site of stalled ribosomes

Journal of structural biology, 2010-03, Vol.169 (3), p.342-348

2010

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A recent intermezzo at the Ribosome Club

Philosophical transactions of the Royal Society of London. Series B. Biological sciences, 2017-03, Vol.372 (1716), p.20160185

2017

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Ribosome formation from subunits studied by stopped-flow and Rayleigh light scattering

Biological procedures online, 2004, Vol.6 (1), p.35-54

2004

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tmRNA-induced Release of Messenger RNA from Stalled Ribosomes

Journal of molecular biology, 2005-07, Vol.350 (5), p.897-905

2005

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A tRNA body with high affinity for EF-Tu hastens ribosomal incorporation of unnatural amino acids

RNA (Cambridge), 2014-05, Vol.20 (5), p.632-643

2014

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Activation of initiation factor 2 by ligands and mutations for rapid docking of ribosomal subunits

The EMBO journal, 2011-01, Vol.30 (2), p.289-301

2011

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Inefficient Delivery but Fast Peptide Bond Formation of Unnatural l‑Aminoacyl-tRNAs in Translation

Journal of the American Chemical Society, 2012-10, Vol.134 (43), p.17955-17962

2012

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Ribosome Rescue by tmRNA Requires Truncated mRNAs

Journal of molecular biology, 2004-04, Vol.338 (1), p.33-41

2004

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Identification of enzyme inhibitory mechanisms from steady-state kinetics

Biochimie, 2011-09, Vol.93 (9), p.1623-1629

2011

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The roles of initiation factor 2 and guanosine triphosphate in initiation of protein synthesis

The EMBO journal, 2003-10, Vol.22 (20), p.5593-5601

2003

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Antibiotic thermorubin tethers ribosomal subunits and impedes A-site interactions to perturb protein synthesis in bacteria

Mechanistic insights into translation inhibition by aminoglycoside antibiotic arbekacin

Optimal control of gene expression for fast proteome adaptation to environmental change

Slow peptide bond formation by proline and other N-alkylamino acids in translation

On the pH Dependence of Class-1 RF-Dependent Termination of mRNA Translation

pH-sensitivity of the ribosomal peptidyl transfer reaction dependent on the identity of the A-site aminoacyl-tRNA

How initiation factors tune the rate of initiation of protein synthesis in bacteria

How Initiation Factors Maximize the Accuracy of tRNA Selection in Initiation of Bacterial Protein Synthesis

Estimation of peptide elongation times from ribosome profiling spectra

Complementary roles of initiation factor 1 and ribosome recycling factor in 70S ribosome splitting

Peptide Formation by N‑Methyl Amino Acids in Translation Is Hastened by Higher pH and tRNAPro

Accuracy of genetic code translation and its orthogonal corruption by aminoglycosides and Mg2+ ions

Substrate-Induced Formation of Ribosomal Decoding Center for Accurate and Rapid Genetic Code Translation

Dynamics of release factor recycling during translation termination in bacteria

Novel Roles for Classical Factors at the Interface between Translation Termination and Initiation

tmRNA·SmpB complex mimics native aminoacyl-tRNAs in the A site of stalled ribosomes

A recent intermezzo at the Ribosome Club

Ribosome formation from subunits studied by stopped-flow and Rayleigh light scattering

tmRNA-induced Release of Messenger RNA from Stalled Ribosomes

A tRNA body with high affinity for EF-Tu hastens ribosomal incorporation of unnatural amino acids

Activation of initiation factor 2 by ligands and mutations for rapid docking of ribosomal subunits

Inefficient Delivery but Fast Peptide Bond Formation of Unnatural l‑Aminoacyl-tRNAs in Translation

Ribosome Rescue by tmRNA Requires Truncated mRNAs

Identification of enzyme inhibitory mechanisms from steady-state kinetics

The roles of initiation factor 2 and guanosine triphosphate in initiation of protein synthesis

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