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A time-of-drug addition approach to target identification of antiviral compounds

Nature protocols, 2011-06, Vol.6 (6), p.925-933

2011

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New non-nucleoside reverse transcriptase inhibitors (NNRTIs) in development for the treatment of HIV infections

Current opinion in pharmacology, 2004-10, Vol.4 (5), p.437-446

Pauwels, Rudi

2004

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TMC114, a Novel Human Immunodeficiency Virus Type 1 Protease Inhibitor Active against Protease Inhibitor-Resistant Viruses, Including a Broad Range of Clinical Isolates

Antimicrobial Agents and Chemotherapy, 2005-06, Vol.49 (6), p.2314-2321

2005

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TMC125 Displays a High Genetic Barrier to the Development of Resistance: Evidence from In Vitro Selection Experiments

Journal of Virology, 2005-10, Vol.79 (20), p.12773-12782

2005

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TMC125, a Novel Next-Generation Nonnucleoside Reverse Transcriptase Inhibitor Active against Nonnucleoside Reverse Transcriptase Inhibitor-Resistant Human Immunodeficiency Virus Type 1

Antimicrobial Agents and Chemotherapy, 2004-12, Vol.48 (12), p.4680-4686

2004

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In Search of a Novel Anti-HIV Drug: Multidisciplinary Coordination in the Discovery of 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, Rilpivirine)

Journal of medicinal chemistry, 2005-03, Vol.48 (6), p.1901-1909

2005

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Discovery and Selection of TMC114, a Next Generation HIV-1 Protease Inhibitor

Journal of medicinal chemistry, 2005-03, Vol.48 (6), p.1813-1822

2005

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Field evaluation of a mobile biosafety laboratory in Senegal to strengthen rapid disease outbreak response and monitoring

African journal of laboratory medicine, 2020, Vol.9 (2), p.1-9

2020

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A Rapid Method for Simultaneous Detection of Phenotypic Resistance to Inhibitors of Protease and Reverse Transcriptase in Recombinant Human Immunodeficiency Virus Type 1 Isolates from Patients Treated with Antiretroviral Drugs

Antimicrobial Agents and Chemotherapy, 1998-02, Vol.42 (2), p.269-276

1998

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Realistic Hope: Facing Global Challenges

1, 2018

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Development of rapid, more automated biomarker diagnostic systems

New biotechnology, 2012-09, Vol.29, p.S27-S27

Pauwels, Rudi

2012

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Aspects of successful drug discovery and development

Antiviral research, 2006-09, Vol.71 (2), p.77-89

Pauwels, Rudi

2006

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Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds

Journal of virological methods, 1988-08, Vol.20 (4), p.309-321

1988

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Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives

Nature (London), 1990-02, Vol.343 (6257), p.470-474

1990

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Betulinic Acid Derivatives: A New Class of Specific Inhibitors of Human Immunodeficiency Virus Type 1 Entry

Journal of medicinal chemistry, 1996-03, Vol.39 (5), p.1069-1083

1996

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Encoding microcarriers: present and future technologies

Nature reviews. Drug discovery, 2002-06, Vol.1 (6), p.447-456

2002

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Patterns of Resistance and Cross-Resistance to Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitors in Patients Treated with the Nonnucleoside Reverse Transcriptase Inhibitor Loviride

Antimicrobial Agents and Chemotherapy, 1998-12, Vol.42 (12), p.3123-3129

1998

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Encoding microcarriers by spatial selective photobleaching

Nature materials, 2003-03, Vol.2 (3), p.169-173

2003

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Both 2′,3′-dideoxythymidine and its 2′,3′-unsaturated derivative (2′,3′-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro

Biochemical and biophysical research communications, 1987-01, Vol.142 (1), p.128-134

1987

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Inhibitory effect of dextran sulfate and heparin on the replication of human immunodeficiency virus (HIV) in vitro

Antiviral research, 1987-07, Vol.7 (6), p.361-367

1987

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Synthesis of Novel Diarylpyrimidine Analogues and Their Antiviral Activity against Human Immunodeficiency Virus Type 1

Journal of medicinal chemistry, 2005-03, Vol.48 (6), p.2072-2079

2005

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Health Systems: Doomed to Fail or About to Be Saved by a Copernican Shift?

Realistic Hope, 2018, p.151-164

2018

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Synthesis and anti-HIV activity of different sugar-modified pyrimidine and purine nucleosides

Journal of medicinal chemistry, 1988-10, Vol.31 (10), p.2040-2048

1988

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A time-of-drug addition approach to target identification of antiviral compounds

New non-nucleoside reverse transcriptase inhibitors (NNRTIs) in development for the treatment of HIV infections

TMC114, a Novel Human Immunodeficiency Virus Type 1 Protease Inhibitor Active against Protease Inhibitor-Resistant Viruses, Including a Broad Range of Clinical Isolates

TMC125 Displays a High Genetic Barrier to the Development of Resistance: Evidence from In Vitro Selection Experiments

TMC125, a Novel Next-Generation Nonnucleoside Reverse Transcriptase Inhibitor Active against Nonnucleoside Reverse Transcriptase Inhibitor-Resistant Human Immunodeficiency Virus Type 1

In Search of a Novel Anti-HIV Drug: Multidisciplinary Coordination in the Discovery of 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, Rilpivirine)

Discovery and Selection of TMC114, a Next Generation HIV-1 Protease Inhibitor

Field evaluation of a mobile biosafety laboratory in Senegal to strengthen rapid disease outbreak response and monitoring

A Rapid Method for Simultaneous Detection of Phenotypic Resistance to Inhibitors of Protease and Reverse Transcriptase in Recombinant Human Immunodeficiency Virus Type 1 Isolates from Patients Treated with Antiretroviral Drugs

Realistic Hope: Facing Global Challenges

Development of rapid, more automated biomarker diagnostic systems

Aspects of successful drug discovery and development

Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds

Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives

Betulinic Acid Derivatives: A New Class of Specific Inhibitors of Human Immunodeficiency Virus Type 1 Entry

Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 Variants

Encoding microcarriers: present and future technologies

Patterns of Resistance and Cross-Resistance to Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitors in Patients Treated with the Nonnucleoside Reverse Transcriptase Inhibitor Loviride

Encoding microcarriers by spatial selective photobleaching

Both 2′,3′-dideoxythymidine and its 2′,3′-unsaturated derivative (2′,3′-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro

Institut Pasteur Dakar Mobile Lab: Part of the Solution to Tackle COVID Pandemic in Senegal, a Model to Be Exploited

Inhibitory effect of dextran sulfate and heparin on the replication of human immunodeficiency virus (HIV) in vitro

Synthesis of Novel Diarylpyrimidine Analogues and Their Antiviral Activity against Human Immunodeficiency Virus Type 1

Health Systems: Doomed to Fail or About to Be Saved by a Copernican Shift?

Synthesis and anti-HIV activity of different sugar-modified pyrimidine and purine nucleosides

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