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Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand

Proceedings of the National Academy of Sciences - PNAS, 2007-03, Vol.104 (12), p.5163-5168

2007

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ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities

The Journal of pharmacology and experimental therapeutics, 2008-12, Vol.327 (3), p.827-839

2008

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MrgD Activation Inhibits KCNQ/M-Currents and Contributes to Enhanced Neuronal Excitability

The Journal of neuroscience, 2007-04, Vol.27 (16), p.4492-4496

2007

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Pharmacological comparison of muscarinic ligands : Historical versus more recent muscarinic M1-preferring receptor agonists

European journal of pharmacology, 2009-03, Vol.605 (1-3), p.53-56

2009

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G-protein-coupled receptors in Saccharomyces cerevisiae: high-throughput screening assays for drug discovery

Trends in biotechnology (Regular ed.), 1997-12, Vol.15 (12), p.487-494

Pausch, Mark H.

1997

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ORK1, a potassium-selective leak channel with two pore domains cloned from Drosophila melanogaster by expression in Saccharomyces cerevisiae. [Erratum: Jan 5, 1999, v. 96 (1), p. 318.]

Proceedings of the National Academy of Sciences - PNAS, 1996-11, Vol.93 (23), p.13256-13261

1996

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Characterization of Gpr101 expression and G-protein coupling selectivity

Brain research, 2006-05, Vol.1087 (1), p.1-14

2006

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Functional expression of human and mouse P2Y12 receptors in Saccharomyces cerevisiae

Biochemical and biophysical research communications, 2004-11, Vol.324 (1), p.171-177

2004

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The identification of neurotensin NTS1 receptor partial agonists through a ligand-based virtual screening approach

Bioorganic & medicinal chemistry, 2008-11, Vol.18 (21), p.5789-5791

2008

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Development of a FLIPR assay for the simultaneous identification of MrgD agonists and antagonists from a single screen

BioMed research international, 2010-01, Vol.2010, p.1-8

2010

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WS-50030 [7-{4-[3-(1H-inden-3-yl)propyl]piperazin-1-yl}-1,3-benzoxazol-2(3H)-one]: a novel dopamine D2 receptor partial agonist/serotonin reuptake inhibitor with preclinical antipsychotic-like and antidepressant-like activity

The Journal of pharmacology and experimental therapeutics, 2010-01, Vol.332 (1), p.190

2010

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Predicting GPCR–G-protein coupling using hidden Markov models

Bioinformatics, 2004-12, Vol.20 (18), p.3490-3499

2004

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Functional expression of M1, M3 and M5 muscarinic acetylcholine receptors in yeast

Journal of neurochemistry, 2001-06, Vol.77 (5), p.1327-1337

2001

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d-Amino Acid Oxidase Activity Is Inhibited by an Interaction with Bassoon Protein at the Presynaptic Active Zone

The Journal of biological chemistry, 2011-08, Vol.286 (33), p.28867-28875

2011

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Identification of MK-8133: An orexin-2 selective receptor antagonist with favorable development properties

Bioorganic & medicinal chemistry letters, 2015-06, Vol.25 (12), p.2488-2492

2015

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Potent dihydroquinolinone dopamine D2 partial agonist/serotonin reuptake inhibitors for the treatment of schizophrenia

Bioorganic & medicinal chemistry letters, 2010-05, Vol.20 (9), p.2983-2986

2010

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Development of a yeast bioassay to characterize G protein-coupled receptor kinases. Identification of an NH2-terminal region essential for receptor phosphorylation

The Journal of biological chemistry, 2003-11, Vol.278 (48), p.47466

2003

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Tissue distribution and functional analyses of the constitutively active orphan G protein coupled receptors, GPR26 and GPR78

Biochimica et biophysica acta, 2007-06, Vol.1770 (6), p.890-901

2007

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Aplindore (DAB-452), a high affinity selective dopamine D2 receptor partial agonist

European journal of pharmacology, 2006-12, Vol.552 (1-3), p.36-45

2006

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Tetrahydrocarbazole-based serotonin reuptake inhibitor/dopamine D2 partial agonists for the potential treatment of schizophrenia

Bioorganic & medicinal chemistry letters, 2009-10, Vol.19 (19), p.5552-5555

2009

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Single Amino Acid Substitutions and Deletions That Alter the G Protein Coupling Properties of the V2 Vasopressin Receptor Identified in Yeast by Receptor Random Mutagenesis

The Journal of biological chemistry, 2001-08, Vol.276 (31), p.29382-29392

2001

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Functional coupling of a mammalian somatostatin receptor to the yeast pheromone response pathway

Molecular and Cellular Biology, 1995-11, Vol.15 (11), p.6188-6195

1995

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Pharmacological comparison of muscarinic ligands: Historical versus more recent muscarinic M 1-preferring receptor agonists

European journal of pharmacology, 2009-03, Vol.605 (1), p.53-56

2009

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Development of a Yeast Bioassay to Characterize G Protein-coupled Receptor Kinases

The Journal of biological chemistry, 2003-11, Vol.278 (48), p.47466-47476

2003

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A Linear Hexapeptide Somatostatin Antagonist Blocks Somatostatin Activity In Vitro and Influences Growth Hormone Release in Rats

Molecular pharmacology, 1998-11, Vol.54 (5), p.864-873

1998

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Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand

ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities

MrgD Activation Inhibits KCNQ/M-Currents and Contributes to Enhanced Neuronal Excitability

Pharmacological comparison of muscarinic ligands : Historical versus more recent muscarinic M1-preferring receptor agonists

G-protein-coupled receptors in Saccharomyces cerevisiae: high-throughput screening assays for drug discovery

ORK1, a potassium-selective leak channel with two pore domains cloned from Drosophila melanogaster by expression in Saccharomyces cerevisiae. [Erratum: Jan 5, 1999, v. 96 (1), p. 318.]

Characterization of Gpr101 expression and G-protein coupling selectivity

Functional expression of human and mouse P2Y12 receptors in Saccharomyces cerevisiae

The identification of neurotensin NTS1 receptor partial agonists through a ligand-based virtual screening approach

Development of a FLIPR assay for the simultaneous identification of MrgD agonists and antagonists from a single screen

WS-50030 [7-{4-[3-(1H-inden-3-yl)propyl]piperazin-1-yl}-1,3-benzoxazol-2(3H)-one]: a novel dopamine D2 receptor partial agonist/serotonin reuptake inhibitor with preclinical antipsychotic-like and antidepressant-like activity

Predicting GPCR–G-protein coupling using hidden Markov models

Functional expression of M1, M3 and M5 muscarinic acetylcholine receptors in yeast

d-Amino Acid Oxidase Activity Is Inhibited by an Interaction with Bassoon Protein at the Presynaptic Active Zone

Identification of MK-8133: An orexin-2 selective receptor antagonist with favorable development properties

Potent dihydroquinolinone dopamine D2 partial agonist/serotonin reuptake inhibitors for the treatment of schizophrenia

Development of a yeast bioassay to characterize G protein-coupled receptor kinases. Identification of an NH2-terminal region essential for receptor phosphorylation

Tissue distribution and functional analyses of the constitutively active orphan G protein coupled receptors, GPR26 and GPR78

Aplindore (DAB-452), a high affinity selective dopamine D2 receptor partial agonist

Tetrahydrocarbazole-based serotonin reuptake inhibitor/dopamine D2 partial agonists for the potential treatment of schizophrenia

Single Amino Acid Substitutions and Deletions That Alter the G Protein Coupling Properties of the V2 Vasopressin Receptor Identified in Yeast by Receptor Random Mutagenesis

Functional coupling of a mammalian somatostatin receptor to the yeast pheromone response pathway

Pharmacological comparison of muscarinic ligands: Historical versus more recent muscarinic M 1-preferring receptor agonists

Development of a Yeast Bioassay to Characterize G Protein-coupled Receptor Kinases

A Linear Hexapeptide Somatostatin Antagonist Blocks Somatostatin Activity In Vitro and Influences Growth Hormone Release in Rats

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