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Analyzing kinetic signaling data for G-protein-coupled receptors

Scientific reports, 2020-07, Vol.10 (1), p.12263, Article 12263

2020

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A kinetic method for measuring agonist efficacy and ligand bias using high resolution biosensors and a kinetic data analysis framework

Scientific reports, 2020-02, Vol.10 (1), p.1766-1766, Article 1766

2020

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Ratiometric biosensors based on dimerization-dependent fluorescent protein exchange

Nature methods, 2015-03, Vol.12 (3), p.195-198

2015

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Cilia have high cAMP levels that are inhibited by Sonic Hedgehog-regulated calcium dynamics

Proceedings of the National Academy of Sciences - PNAS, 2016-11, Vol.113 (46), p.13069-13074

2016

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New DAG and cAMP Sensors Optimized for Live-Cell Assays in Automated Laboratories

Journal of biomolecular screening, 2016-03, Vol.21 (3), p.298-305

2016

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Quantifying the Kinetics of Signaling and Arrestin Recruitment by Nervous System G-Protein Coupled Receptors

Frontiers in cellular neuroscience, 2022-01, Vol.15, p.814547-814547

2022

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A multiplexed fluorescent assay for independent second-messenger systems: decoding GPCR activation in living cells

Journal of biomolecular screening, 2013-08, Vol.18 (7), p.797-806

2013

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Diazoxide-Unresponsive Congenital Hyperinsulinism in Children With Dominant Mutations of the β-Cell Sulfonylurea Receptor SUR1

Diabetes (New York, N.Y.), 2011-06, Vol.60 (6), p.1797-1804

2011

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Simultaneous detection of Ca2+ and diacylglycerol signaling in living cells

PloS one, 2012-08, Vol.7 (8), p.e42791-e42791

2012

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Correction: Simultaneous Detection of Ca and Diacylglycerol Signaling in Living Cells

PloS one, 2014-01, Vol.9 (1)

2014

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Measuring the Kinetics of G‐protein‐coupled Receptor Signaling and Biased Agonism

The FASEB journal, 2020-04, Vol.34 (S1), p.1-1

2020

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Measuring partial and biased agonism at GPCRs on the FDSS/μCell

The FASEB journal, 2021-05, Vol.35 (S1), p.n/a, Article fasebj.2021.35.S1.04363

2021

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Characterization and Functional Restoration of a Potassium Channel Kir6.2 Pore Mutation Identified in Congenital Hyperinsulinism

The Journal of biological chemistry, 2010-02, Vol.285 (9), p.6012-6023

2010

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Dynamic Measurements of Gi Signaling in Living Cells

The FASEB journal, 2016-04, Vol.30 (S1)

2016

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PKC-dependent Phosphorylation of the H1 Histamine Receptor Modulates TRPC6 Activity

Cells (Basel, Switzerland), 2014-04, Vol.3 (2), p.247-257

2014

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GENIe: A bright new genetically‐encoded fluorescent biosensor for monitoring cGMP

The FASEB journal, 2018-04, Vol.32 (S1), p.lb638-lb638

2018

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Development and Delivery of Robust Biosensors for Measuring Signal Transduction in Living Cells

The FASEB journal, 2016-04, Vol.30 (S1)

2016

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Assay for Detecting Gαi-Mediated Decreases in cAMP in Living Cells

SLAS discovery, 2018-10, Vol.23 (9), p.898-906

2018

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Human iPS Cardiomyocytes with Genetically-encoded, Fluorescent Ca2 +, Voltage and cAMP Sensors Reveal Novel Kinetics Around cAMP Signaling: Implications for Drug Safety Screening

Journal of pharmacological and toxicological methods, 2017-11, Vol.88, p.198-198

2017

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Correction: Simultaneous Detection of Ca 2+ and Diacylglycerol Signaling in Living Cells

PloS one, 2014-01, Vol.9 (1)

2014

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Chicken protocadherin-1 functions to localize neural crest cells to the dorsal root ganglia during PNS formation

Mechanisms of development, 2008-11, Vol.125 (11), p.1033-1047

2008

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Simultaneous Detection of Ca.sup.2+ and Diacylglycerol Signaling in Living Cells

PloS one, 2012-08, Vol.7 (8), p.e42791

2012

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N-terminal transmembrane domain of SUR1 controls gating of Kir6.2 by modulating channel sensitivity to PIP2

The Journal of general physiology, 2011-03, Vol.137 (3), p.299-314

2011

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Sulfonylurea Receptor Transmembrane Domain Zero Mutations that Disrupt Full Length and Minimal ATP-Sensitive Potassium Channel Properties

Biophysical journal, 2010-01, Vol.98 (3), p.699a-699a

2010

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Rescue and Gating of a Disease Mutation at an M2 glycine in Kir6.2 of ATP-Sensitive Potassium (KATP) Channels

Biophysical journal, 2009-02, Vol.96 (3), p.465a-466a

2009

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Analyzing kinetic signaling data for G-protein-coupled receptors

A kinetic method for measuring agonist efficacy and ligand bias using high resolution biosensors and a kinetic data analysis framework

Ratiometric biosensors based on dimerization-dependent fluorescent protein exchange

Cilia have high cAMP levels that are inhibited by Sonic Hedgehog-regulated calcium dynamics

New DAG and cAMP Sensors Optimized for Live-Cell Assays in Automated Laboratories

Quantifying the Kinetics of Signaling and Arrestin Recruitment by Nervous System G-Protein Coupled Receptors

A multiplexed fluorescent assay for independent second-messenger systems: decoding GPCR activation in living cells

Diazoxide-Unresponsive Congenital Hyperinsulinism in Children With Dominant Mutations of the β-Cell Sulfonylurea Receptor SUR1

Simultaneous detection of Ca2+ and diacylglycerol signaling in living cells

Correction: Simultaneous Detection of Ca and Diacylglycerol Signaling in Living Cells

Measuring the Kinetics of G‐protein‐coupled Receptor Signaling and Biased Agonism

Measuring partial and biased agonism at GPCRs on the FDSS/μCell

Characterization and Functional Restoration of a Potassium Channel Kir6.2 Pore Mutation Identified in Congenital Hyperinsulinism

Dynamic Measurements of Gi Signaling in Living Cells

PKC-dependent Phosphorylation of the H1 Histamine Receptor Modulates TRPC6 Activity

GENIe: A bright new genetically‐encoded fluorescent biosensor for monitoring cGMP

Development and Delivery of Robust Biosensors for Measuring Signal Transduction in Living Cells

Assay for Detecting Gαi-Mediated Decreases in cAMP in Living Cells

Human iPS Cardiomyocytes with Genetically-encoded, Fluorescent Ca2 +, Voltage and cAMP Sensors Reveal Novel Kinetics Around cAMP Signaling: Implications for Drug Safety Screening

Correction: Simultaneous Detection of Ca 2+ and Diacylglycerol Signaling in Living Cells

Chicken protocadherin-1 functions to localize neural crest cells to the dorsal root ganglia during PNS formation

Simultaneous Detection of Ca.sup.2+ and Diacylglycerol Signaling in Living Cells

N-terminal transmembrane domain of SUR1 controls gating of Kir6.2 by modulating channel sensitivity to PIP2

Sulfonylurea Receptor Transmembrane Domain Zero Mutations that Disrupt Full Length and Minimal ATP-Sensitive Potassium Channel Properties

Rescue and Gating of a Disease Mutation at an M2 glycine in Kir6.2 of ATP-Sensitive Potassium (KATP) Channels

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