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A High-Throughput BRET Cellular Target Engagement Assay Links Biochemical to Cellular Activity for Bruton’s Tyrosine Kinase

SLAS discovery, 2020-02, Vol.25 (2), p.176-185

2020

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Rapid and Accurate Assessment of Diuretic Response: Validation of an Equation to Predict Diuretic Induced Sodium Output Using a Spot Urine Sample

Journal of cardiac failure, 2019-08, Vol.25 (8), p.S52-S53

2019

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Relationship between “Dry Weight” and Actual Weight Loss in Patients Hospitalized for Heart Failure

Journal of cardiac failure, 2019-08, Vol.25 (8), p.S51-S52

2019

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Urine Growth Differentiation Factor-15 is Not an Independent Biomarker of Cardio-Renal Interactions in Patients with Heart Failure

Journal of cardiac failure, 2019-08, Vol.25 (8), p.S21-S22

2019

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Safety and Efficacy of an Auto-Titrating Diuretic Protocol: A Pilot

Journal of cardiac failure, 2019-08, Vol.25 (8), p.S52-S52

2019

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Prevalence of Bladder Dysfunction in Acute Decompensated Heart Failure

Journal of cardiac failure, 2019-08, Vol.25 (8), p.S67-S67

2019

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Discordance between Estimate Glomerular Filtration Rate with Creatinine and Cystatin is Associated with Inflammation and Worsened Survival in Heart Failure

Journal of cardiac failure, 2019-08, Vol.25 (8), p.S20-S20

2019

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Renal Diuretic Delivery is Highly Variable in Hospitalized Decompensated Heart Failure Patients and Associated with Diuretic Resistance

Journal of cardiac failure, 2019-08, Vol.25 (8), p.S3-S3

2019

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Sarcopenia Strongly Affects Serum Levels of Cystatin C in Patients with Heart Failure

Journal of cardiac failure, 2019-08, Vol.25 (8), p.S20-S21

2019

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FGF-23 and Cardio-Renal Interactions in Heart Failure

Journal of cardiac failure, 2019-08, Vol.25 (8), p.S23-S24

2019

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Biomarkers of Intravascular and Extravascular Volume Overload: Associations with Parameters of Cardio-Renal Dysfunction

Journal of cardiac failure, 2019-08, Vol.25 (8), p.S21-S21

2019

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Specific binding of Haemophilus influenzae to minor gangliosides of human respiratory epithelial cells

Infection and Immunity, 1997-05, Vol.65 (5), p.1695-1700

1997

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BMS-345541 Is a Highly Selective Inhibitor of IκB Kinase That Binds at an Allosteric Site of the Enzyme and Blocks NF-κB-dependent Transcription in Mice

The Journal of biological chemistry, 2003-01, Vol.278 (3), p.1450-1456

2003

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Gangliosides of monocyte-derived macrophages of adults with advanced HIV infection show reduced surface accessibility

Journal of leukocyte biology, 1998-09, Vol.64 (3), p.311-321

1998

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A monoclonal antibody to human macrophage gangliosides inhibits macrophage migration

Journal of leukocyte biology, 1996-03, Vol.59 (3), p.371-379

1996

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A highly selective inhibitor of IκB kinase, BMS‐345541, blocks both joint inflammation and destruction in collagen‐induced arthritis in mice

Arthritis and rheumatism, 2003-09, Vol.48 (9), p.2652-2659

2003

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BMS-345541 Is a Highly Selective Inhibitor of I[kappa]B Kinase That Binds at an Allosteric Site of the Enzyme and Blocks NF-[kappa]B-dependent Transcription in Mice

The Journal of biological chemistry, 2003-01, Vol.278 (3), p.1450-1456

2003

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Bruton's tyrosine kinase inhibitor BMS-986142 in experimental models of rheumatoid arthritis enhances efficacy of agents representing clinical standard-of-care

PloS one, 2017-07, Vol.12 (7), p.e0181782-e0181782

2017

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Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton’s Tyrosine Kinase (BTK)

Journal of medicinal chemistry, 2019-04, Vol.62 (7), p.3228-3250

2019

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Discovery of 6‑Fluoro-5‑(R)‑(3‑(S)‑(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)‑yl)-2-methylphenyl)-2‑(S)‑(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro‑1H‑carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton’s Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers

Journal of medicinal chemistry, 2016-10, Vol.59 (19), p.9173-9200

2016

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Determination of Real Time in Vivo Drug Receptor Occupancy for a Covalent Binding Drug as a Clinical Pharmacodynamic Biomarker by Immunocapture-LC-MS/MS

Analytical chemistry (Washington), 2019-07, Vol.91 (13), p.8443-8452

2019

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Driving Potency with Rotationally Stable Atropisomers: Discovery of Pyridopyrimidinedione-Carbazole Inhibitors of BTK

ACS medicinal chemistry letters, 2020-11, Vol.11 (11), p.2195-2203

2020

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INFERIOR VENA CAVA DIAMETER MEASUREMENT PROVIDES DISTINCT AND COMPLEMENTARY INFORMATION TO RIGHT ATRIAL PRESSURE IN ACUTE DECOMPENSATED HEART FAILURE

Journal of the American College of Cardiology, 2019-03, Vol.73 (9), p.1006-1006

2019

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SOLUBLE TNFR1 AS A NEW NOVEL BIOMARKER OF CARDIO-RENAL DYSFUNCTION

Journal of the American College of Cardiology, 2019-03, Vol.73 (9), p.1028-1028

2019

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Synthesis and structure–activity relationship of imidazo(1,2- a)thieno(3,2- e)pyrazines as IKK-β inhibitors

Bioorganic & medicinal chemistry letters, 2007-08, Vol.17 (15), p.4284-4289

2007

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A High-Throughput BRET Cellular Target Engagement Assay Links Biochemical to Cellular Activity for Bruton’s Tyrosine Kinase

Rapid and Accurate Assessment of Diuretic Response: Validation of an Equation to Predict Diuretic Induced Sodium Output Using a Spot Urine Sample

Relationship between “Dry Weight” and Actual Weight Loss in Patients Hospitalized for Heart Failure

Urine Growth Differentiation Factor-15 is Not an Independent Biomarker of Cardio-Renal Interactions in Patients with Heart Failure

Safety and Efficacy of an Auto-Titrating Diuretic Protocol: A Pilot

Prevalence of Bladder Dysfunction in Acute Decompensated Heart Failure

Discordance between Estimate Glomerular Filtration Rate with Creatinine and Cystatin is Associated with Inflammation and Worsened Survival in Heart Failure

Renal Diuretic Delivery is Highly Variable in Hospitalized Decompensated Heart Failure Patients and Associated with Diuretic Resistance

Sarcopenia Strongly Affects Serum Levels of Cystatin C in Patients with Heart Failure

FGF-23 and Cardio-Renal Interactions in Heart Failure

Biomarkers of Intravascular and Extravascular Volume Overload: Associations with Parameters of Cardio-Renal Dysfunction

Specific binding of Haemophilus influenzae to minor gangliosides of human respiratory epithelial cells

BMS-345541 Is a Highly Selective Inhibitor of IκB Kinase That Binds at an Allosteric Site of the Enzyme and Blocks NF-κB-dependent Transcription in Mice

Gangliosides of monocyte-derived macrophages of adults with advanced HIV infection show reduced surface accessibility

A monoclonal antibody to human macrophage gangliosides inhibits macrophage migration

A highly selective inhibitor of IκB kinase, BMS‐345541, blocks both joint inflammation and destruction in collagen‐induced arthritis in mice

BMS-345541 Is a Highly Selective Inhibitor of I[kappa]B Kinase That Binds at an Allosteric Site of the Enzyme and Blocks NF-[kappa]B-dependent Transcription in Mice

Bruton's tyrosine kinase inhibitor BMS-986142 in experimental models of rheumatoid arthritis enhances efficacy of agents representing clinical standard-of-care

Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton’s Tyrosine Kinase (BTK)

Determination of Real Time in Vivo Drug Receptor Occupancy for a Covalent Binding Drug as a Clinical Pharmacodynamic Biomarker by Immunocapture-LC-MS/MS

Driving Potency with Rotationally Stable Atropisomers: Discovery of Pyridopyrimidinedione-Carbazole Inhibitors of BTK

INFERIOR VENA CAVA DIAMETER MEASUREMENT PROVIDES DISTINCT AND COMPLEMENTARY INFORMATION TO RIGHT ATRIAL PRESSURE IN ACUTE DECOMPENSATED HEART FAILURE

SOLUBLE TNFR1 AS A NEW NOVEL BIOMARKER OF CARDIO-RENAL DYSFUNCTION

Synthesis and structure–activity relationship of imidazo(1,2- a)thieno(3,2- e)pyrazines as IKK-β inhibitors

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