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Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified γ-secretase complexes

PloS one, 2012-04, Vol.7 (4), p.e35133-e35133

2012

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The metalloprotease ADAMTS4 generates N-truncated Aβ4–x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer’s disease

Acta neuropathologica, 2019-02, Vol.137 (2), p.239-257

2019

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The Alzheimer’s Disease γ-Secretase Generates Higher 42:40 Ratios for β-Amyloid Than for p3 Peptides

Cell reports (Cambridge), 2017-06, Vol.19 (10), p.1967-1976

2017

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Induction of Amyloid-β42 Production by Fipronil and Other Pyrazole Insecticides

Journal of Alzheimer's disease, 2018, Vol.62 (4), p.1663-1681

2018

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A delay in vesicle endocytosis by a C-terminal fragment of N-cadherin enhances Aβ synaptotoxicity

Cell death discovery, 2023-12, Vol.9 (1), p.444-444, Article 444

2023

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A Compressible Scaffold for Minimally Invasive Delivery of Large Intact Neuronal Networks

Advanced healthcare materials, 2015-01, Vol.4 (2), p.301-312

2015

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Electron Microscopic Structure of Purified, Active γ-Secretase Reveals an Aqueous Intramembrane Chamber and Two Pores

Proceedings of the National Academy of Sciences - PNAS, 2006-05, Vol.103 (18), p.6889-6894

2006

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The lipidome associated with the γ-secretase complex is required for its integrity and activity

Biochemical journal, 2016-02, Vol.473 (3), p.321-334

2016

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Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease

Neurobiology of disease, 2015-02, Vol.74, p.144-157

2015

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Identification of truncated C‐terminal fragments of the Alzheimer’s disease amyloid protein precursor derived from sequential proteolytic pathways

Journal of neurochemistry, 2021-03, Vol.156 (6), p.943-956

2021

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Inactivation of brain Cofilin-1 by age, Alzheimer's disease and γ-secretase

Biochimica et biophysica acta, 2014-12, Vol.1842 (12), p.2500-2509

2014

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The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer's disease

Acta neuropathologica communications, 2019-01, Vol.7 (1), p.13-13, Article 13

2019

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Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production

The Journal of biological chemistry, 2017-03, Vol.292 (9), p.3751-3767

2017

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Processing of the Synaptic Cell Adhesion Molecule Neurexin-3β by Alzheimer Disease α- and γ-Secretases

The Journal of biological chemistry, 2011-01, Vol.286 (4), p.2762-2773

2011

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Perturbations of the Straight Transmembrane α-Helical Structure of the Amyloid Precursor Protein Affect Its Processing by γ-Secretase

The Journal of biological chemistry, 2014-03, Vol.289 (10), p.6763-6774

2014

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The FDA-approved natural product dihydroergocristine reduces the production of the Alzheimer's disease amyloid-β peptides

Scientific reports, 2015-11, Vol.5 (1), p.16541, Article 16541

2015

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Gene expression profiling in cells with enhanced gamma-secretase activity

PloS one, 2009-09, Vol.4 (9), p.e6952-e6952

2009

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Regulated intramembrane proteolysis of the AXL receptor kinase generates an intracellular domain that localizes in the nucleus of cancer cells

The FASEB journal, 2017-04, Vol.31 (4), p.1382-1397

2017

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Shedding of neurexin 3β ectodomain by ADAM10 releases a soluble fragment that affects the development of newborn neurons

Scientific reports, 2016-12, Vol.6 (1), p.39310-39310, Article 39310

2016

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Label-free imaging of cerebral β-amyloidosis with extended-focus optical coherence microscopy

The Journal of neuroscience, 2012-10, Vol.32 (42), p.14548-14556

2012

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Alzheimer's disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production

Nature communications, 2013, Vol.4 (1), p.2246-2246, Article 2246

2013

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The adipocyte differentiation protein APMAP is an endogenous suppressor of Aβ production in the brain

Human molecular genetics, 2015-01, Vol.24 (2), p.371-382

2015

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Substrate-targeting γ-secretase modulators

Nature (London), 2008-06, Vol.453 (7197), p.925-929

2008

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Cryoelectron Microscopy Structure of Purified γ-Secretase at 12 Å Resolution

Journal of molecular biology, 2009-01, Vol.385 (2), p.642-652

2009

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The Role of γ-Secretase Activating Protein (GSAP) and Imatinib in the Regulation of γ-Secretase Activity and Amyloid-β Generation

The Journal of biological chemistry, 2013-01, Vol.288 (4), p.2521-2531

2013

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Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified γ-secretase complexes

The metalloprotease ADAMTS4 generates N-truncated Aβ4–x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer’s disease

The Alzheimer’s Disease γ-Secretase Generates Higher 42:40 Ratios for β-Amyloid Than for p3 Peptides

Induction of Amyloid-β42 Production by Fipronil and Other Pyrazole Insecticides

A delay in vesicle endocytosis by a C-terminal fragment of N-cadherin enhances Aβ synaptotoxicity

A Compressible Scaffold for Minimally Invasive Delivery of Large Intact Neuronal Networks

Electron Microscopic Structure of Purified, Active γ-Secretase Reveals an Aqueous Intramembrane Chamber and Two Pores

The lipidome associated with the γ-secretase complex is required for its integrity and activity

Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease

Identification of truncated C‐terminal fragments of the Alzheimer’s disease amyloid protein precursor derived from sequential proteolytic pathways

Inactivation of brain Cofilin-1 by age, Alzheimer's disease and γ-secretase

The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer's disease

Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production

Processing of the Synaptic Cell Adhesion Molecule Neurexin-3β by Alzheimer Disease α- and γ-Secretases

Perturbations of the Straight Transmembrane α-Helical Structure of the Amyloid Precursor Protein Affect Its Processing by γ-Secretase

The FDA-approved natural product dihydroergocristine reduces the production of the Alzheimer's disease amyloid-β peptides

Gene expression profiling in cells with enhanced gamma-secretase activity

Regulated intramembrane proteolysis of the AXL receptor kinase generates an intracellular domain that localizes in the nucleus of cancer cells

Shedding of neurexin 3β ectodomain by ADAM10 releases a soluble fragment that affects the development of newborn neurons

Label-free imaging of cerebral β-amyloidosis with extended-focus optical coherence microscopy

Alzheimer's disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production

The adipocyte differentiation protein APMAP is an endogenous suppressor of Aβ production in the brain

Substrate-targeting γ-secretase modulators

Cryoelectron Microscopy Structure of Purified γ-Secretase at 12 Å Resolution

The Role of γ-Secretase Activating Protein (GSAP) and Imatinib in the Regulation of γ-Secretase Activity and Amyloid-β Generation

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