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Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine

Nature chemical biology, 2022-12, Vol.18 (12), p.1388-1398

2022

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Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2

Nature chemical biology, 2011-04, Vol.7 (4), p.203-205

2011

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Functional Interplay between Caspase Cleavage and Phosphorylation Sculpts the Apoptotic Proteome

Cell, 2012-07, Vol.150 (2), p.426-440

2012

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Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways

Proceedings of the National Academy of Sciences - PNAS, 2011-03, Vol.108 (12), p.4834-4839

2011

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Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8), p.2574-2586

2013

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Pharmacological Inhibition of BMK1 Suppresses Tumor Growth through Promyelocytic Leukemia Protein

Cancer cell, 2010-09, Vol.18 (3), p.258-267

2010

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Fragment-based covalent ligand discovery

RSC chemical biology, 2021-04, Vol.2 (2), p.354-367

2021

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Functional Interrogation of the Kinome Using Nucleotide Acyl Phosphates

Biochemistry (Easton), 2007-01, Vol.46 (2), p.350-358

2007

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Supersensitivity to Anandamide and Enhanced Endogenous Cannabinoid Signaling in Mice Lacking Fatty Acid Amide Hydrolase

Proceedings of the National Academy of Sciences - PNAS, 2001-07, Vol.98 (16), p.9371-9376

2001

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Activity-Based Protein Profiling: The Serine Hydrolases

Proceedings of the National Academy of Sciences - PNAS, 1999-12, Vol.96 (26), p.14694-14699

1999

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Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor

Cell, 2018-01, Vol.172 (3), p.578-589.e17

2018

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Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State

Cancer discovery, 2016-03, Vol.6 (3), p.316-329

2016

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Profiling Protein Kinases and Other ATP Binding Proteins in Arabidopsis Using Acyl-ATP Probes

Molecular & cellular proteomics, 2013-09, Vol.12 (9), p.2481-2496

2013

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Identification of a Tumor Specific, Active-Site Mutation in Casein Kinase 1α by Chemical Proteomics

PloS one, 2016-03, Vol.11 (3), p.e0152934-e0152934

2016

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Correction: Identification of a Tumor Specific, Active-Site Mutation in Casein Kinase 1α by Chemical Proteomics

PloS one, 2017, Vol.12 (2), p.e0172649-e0172649

2017

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Mapping Enzyme Active Sites in Complex Proteomes

Journal of the American Chemical Society, 2004-02, Vol.126 (5), p.1363-1368

2004

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High-Resolution Functional Proteomics by Active-Site Peptide Profiling

Proceedings of the National Academy of Sciences - PNAS, 2005-04, Vol.102 (14), p.4996-5001

2005

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Author Correction: Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine

Nature chemical biology, 2022-11, Vol.18 (11), p.1288-1288

2022

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Brain Penetrant LRRK2 Inhibitor

ACS medicinal chemistry letters, 2012-08, Vol.3 (8), p.658-662

2012

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Kinome-wide Selectivity Profiling of ATP-competitive Mammalian Target of Rapamycin (mTOR) Inhibitors and Characterization of Their Binding Kinetics

The Journal of biological chemistry, 2012-03, Vol.287 (13), p.9742-9752

2012

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Characterization and Manipulation of the Acyl Chain Selectivity of Fatty Acid Amide Hydrolase

Biochemistry (Easton), 2001-05, Vol.40 (20), p.6107-6115

2001

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In Situ Kinase Profiling Reveals Functionally Relevant Properties of Native Kinases

Chemistry & biology, 2011-06, Vol.18 (6), p.699-710

2011

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Proteomics analysis of cardiac muscle from rats with peroxisomal proliferator-activated receptor α (PPARα) stimulation

The Journal of Toxicological Sciences, 2010/02/01, Vol.35(1), pp.131-135

2010

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Identification of novel therapeutic targets in acute leukemias with NRAS mutations using a pharmacologic approach

Blood, 2015-05, Vol.125 (20), p.3133-3143

2015

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Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine

Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2

Functional Interplay between Caspase Cleavage and Phosphorylation Sculpts the Apoptotic Proteome

Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways

Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR

Pharmacological Inhibition of BMK1 Suppresses Tumor Growth through Promyelocytic Leukemia Protein

Fragment-based covalent ligand discovery

Functional Interrogation of the Kinome Using Nucleotide Acyl Phosphates

Supersensitivity to Anandamide and Enhanced Endogenous Cannabinoid Signaling in Mice Lacking Fatty Acid Amide Hydrolase

Activity-Based Protein Profiling: The Serine Hydrolases

Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor

Pathophysiological significance and therapeutic targeting of germinal center kinase in diffuse large B-cell lymphoma

Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State

Profiling Protein Kinases and Other ATP Binding Proteins in Arabidopsis Using Acyl-ATP Probes

Identification of a Tumor Specific, Active-Site Mutation in Casein Kinase 1α by Chemical Proteomics

Correction: Identification of a Tumor Specific, Active-Site Mutation in Casein Kinase 1α by Chemical Proteomics

Mapping Enzyme Active Sites in Complex Proteomes

High-Resolution Functional Proteomics by Active-Site Peptide Profiling

Author Correction: Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine

Brain Penetrant LRRK2 Inhibitor

Kinome-wide Selectivity Profiling of ATP-competitive Mammalian Target of Rapamycin (mTOR) Inhibitors and Characterization of Their Binding Kinetics

Characterization and Manipulation of the Acyl Chain Selectivity of Fatty Acid Amide Hydrolase

In Situ Kinase Profiling Reveals Functionally Relevant Properties of Native Kinases

Proteomics analysis of cardiac muscle from rats with peroxisomal proliferator-activated receptor α (PPARα) stimulation

Identification of novel therapeutic targets in acute leukemias with NRAS mutations using a pharmacologic approach

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