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Neutral polymer micelle carriers with pH-responsive, endosome-releasing activity modulate antigen trafficking to enhance CD8+ T cell responses

Journal of controlled release, 2014-10, Vol.191, p.24-33

2014

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Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule-Related Therapeutic Modalities

Drug metabolism and disposition, 2019-10, Vol.47 (10), p.1122-1135

2019

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Sequential metabolism kinetics of Δ9-Tetrahydrocannabinol (THC) and ITS Psychoactive 11-OH-THC Metabolite

Drug metabolism and pharmacokinetics, 2019-01, Vol.34 (1), p.S60-S60

2019

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Development of a Novel Maternal-Fetal Physiologically Based Pharmacokinetic Model I: Insights into Factors that Determine Fetal Drug Exposure through Simulations and Sensitivity Analyses

Drug metabolism and disposition, 2017-08, Vol.45 (8), p.920-938

2017

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P216 - Development and verification of a linked THC/11-OH-THC PBPK model in healthy subjects and extrapolation to pregnancy

Drug metabolism and pharmacokinetics, 2020, Vol.35 (1), p.S88-S88

2020

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Development and Verification of a Linked Δ 9 -THC/11-OH-THC Physiologically Based Pharmacokinetic Model in Healthy, Nonpregnant Population and Extrapolation to Pregnant Women

Drug metabolism and disposition, 2021-07, Vol.49 (7), p.509-520

2021

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When Does the Rate-Determining Step in the Hepatic Clearance of a Drug Switch from Sinusoidal Uptake to All Hepatobiliary Clearances? Implications for Predicting Drug-Drug Interactions

Drug metabolism and disposition, 2018-11, Vol.46 (11), p.1487-1496

2018

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Fractional contribution of CYP and UGT enzymes to the disposition of cannabinoids

Drug metabolism and pharmacokinetics, 2018-01, Vol.33 (1), p.S74-S75

2018

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When does the rate-determining step in hepatic clearance of a drug switch from sinusoidal uptake clearance to all hepatobiliary clearances?

Drug metabolism and pharmacokinetics, 2018-01, Vol.33 (1), p.S28-S28

2018

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Characterizing and Quantifying Extrahepatic Metabolism of (-)-Δ9-Tetrahydrocannabinol (THC) and Its Psychoactive Metabolite, (±)-11-Hydroxy-Δ9-THC (11-OH-THC)

Drug metabolism and disposition, 2022-06, Vol.50 (6), p.734-740

2022

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Characterizing and Quantifying Extrahepatic Metabolism of (-)-Δ 9 -Tetrahydrocannabinol (THC) and Its Psychoactive Metabolite, (±)-11-Hydroxy-Δ 9 -THC (11-OH-THC)

Drug metabolism and disposition, 2022-06, Vol.50 (6), p.734-740

2022

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Quantifying Hepatic Enzyme Kinetics of (-)-∆ 9 -Tetrahydrocannabinol (THC) and Its Psychoactive Metabolite, 11-OH-THC, through In Vitro Modeling

Drug metabolism and disposition, 2019-07, Vol.47 (7), p.743-752

2019

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Hepatic Enzymes Relevant to the Disposition of (-)-∆ 9 -Tetrahydrocannabinol (THC) and Its Psychoactive Metabolite, 11-OH-THC

Drug metabolism and disposition, 2019-03, Vol.47 (3), p.249-256

2019

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SGN-B6A: A New Vedotin Antibody–Drug Conjugate Directed to Integrin Beta-6 for Multiple Carcinoma Indications

Molecular cancer therapeutics, 2023-12, Vol.22 (12), p.1444-1453

2023

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Transport vs. Metabolism: What Determines the Pharmacokinetics and Pharmacodynamics of Drugs? Insights From the Extended Clearance Model

Clinical pharmacology and therapeutics, 2016-11, Vol.100 (5), p.413-418

2016

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Development and Verification of a Linked Δ9-THC/11-OH-THC Physiologically Based Pharmacokinetic Model in Healthy, Nonpregnant Population and Extrapolation to Pregnant Women

Drug metabolism and disposition, 2021-07, Vol.49 (7), p.509-520

2021

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Enhancement of Microbiota in Healthy Macaques Results in Beneficial Modulation of Mucosal and Systemic Immune Function

The Journal of immunology (1950), 2016-03, Vol.196 (5), p.2401-2409

2016

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Quantitative transporter proteomics by liquid chromatography with tandem mass spectrometry: addressing methodologic issues of plasma membrane isolation and expression-activity relationship

Drug metabolism and disposition, 2015-02, Vol.43 (2), p.284-288

2015

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Novel insights into predicting hepatic DDI liabilities when transporters and enzymes are involved

Drug metabolism and pharmacokinetics, 2019-01, Vol.34 (1), p.S15-S15

2019

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A marijuana-drug interaction primer: Precipitants, pharmacology, and pharmacokinetics

Pharmacology & therapeutics (Oxford), 2019-09, Vol.201, p.25-38

2019

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Efficacy and safety of sigvotatug vedotin, an investigational ADC, in NSCLC: Updated phase 1 results (SGNB6A-001)

Journal of clinical oncology, 2024-06, Vol.42 (16_suppl), p.8521-8521

2024

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Enhancement of Microbiota in Healthy Macaques Results in Beneficial Modulation of Mucosal and Systemic Immune Function1

The Journal of immunology (1950), 2016-01, Vol.196 (5), p.2401-2409

2016

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PREDICTING FETAL EXPOSURE TO DRUGS THROUGHOUT PREGNANCY USING A PBPK MODEL

The FASEB journal, 2016-04, Vol.30 (S1)

2016

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Abstract 5668: Using clinical utility index (CUI) to determine the optimal biological dose of a nonfucosylated anti-TIGIT antibody: A proposed alternative to maximum tolerated dose (MTD)

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.5668-5668

2023

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Predicting Maternal-Fetal Cannabinoid Exposure during Pregnancy Using Physiologically-Based Pharmacokinetic Modeling and Simulation

Patilea-Vrana, Gabriela

2019

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Neutral polymer micelle carriers with pH-responsive, endosome-releasing activity modulate antigen trafficking to enhance CD8+ T cell responses

Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule-Related Therapeutic Modalities

Sequential metabolism kinetics of Δ9-Tetrahydrocannabinol (THC) and ITS Psychoactive 11-OH-THC Metabolite

Development of a Novel Maternal-Fetal Physiologically Based Pharmacokinetic Model I: Insights into Factors that Determine Fetal Drug Exposure through Simulations and Sensitivity Analyses

P216 - Development and verification of a linked THC/11-OH-THC PBPK model in healthy subjects and extrapolation to pregnancy

Development and Verification of a Linked Δ 9 -THC/11-OH-THC Physiologically Based Pharmacokinetic Model in Healthy, Nonpregnant Population and Extrapolation to Pregnant Women

When Does the Rate-Determining Step in the Hepatic Clearance of a Drug Switch from Sinusoidal Uptake to All Hepatobiliary Clearances? Implications for Predicting Drug-Drug Interactions

Fractional contribution of CYP and UGT enzymes to the disposition of cannabinoids

When does the rate-determining step in hepatic clearance of a drug switch from sinusoidal uptake clearance to all hepatobiliary clearances?

Characterizing and Quantifying Extrahepatic Metabolism of (-)-Δ9-Tetrahydrocannabinol (THC) and Its Psychoactive Metabolite, (±)-11-Hydroxy-Δ9-THC (11-OH-THC)

Characterizing and Quantifying Extrahepatic Metabolism of (-)-Δ 9 -Tetrahydrocannabinol (THC) and Its Psychoactive Metabolite, (±)-11-Hydroxy-Δ 9 -THC (11-OH-THC)

Quantifying Hepatic Enzyme Kinetics of (-)-∆ 9 -Tetrahydrocannabinol (THC) and Its Psychoactive Metabolite, 11-OH-THC, through In Vitro Modeling

Hepatic Enzymes Relevant to the Disposition of (-)-∆ 9 -Tetrahydrocannabinol (THC) and Its Psychoactive Metabolite, 11-OH-THC

SGN-B6A: A New Vedotin Antibody–Drug Conjugate Directed to Integrin Beta-6 for Multiple Carcinoma Indications

Transport vs. Metabolism: What Determines the Pharmacokinetics and Pharmacodynamics of Drugs? Insights From the Extended Clearance Model

Development and Verification of a Linked Δ9-THC/11-OH-THC Physiologically Based Pharmacokinetic Model in Healthy, Nonpregnant Population and Extrapolation to Pregnant Women

Enhancement of Microbiota in Healthy Macaques Results in Beneficial Modulation of Mucosal and Systemic Immune Function

Quantitative transporter proteomics by liquid chromatography with tandem mass spectrometry: addressing methodologic issues of plasma membrane isolation and expression-activity relationship

Novel insights into predicting hepatic DDI liabilities when transporters and enzymes are involved

A marijuana-drug interaction primer: Precipitants, pharmacology, and pharmacokinetics

Efficacy and safety of sigvotatug vedotin, an investigational ADC, in NSCLC: Updated phase 1 results (SGNB6A-001)

Enhancement of Microbiota in Healthy Macaques Results in Beneficial Modulation of Mucosal and Systemic Immune Function1

PREDICTING FETAL EXPOSURE TO DRUGS THROUGHOUT PREGNANCY USING A PBPK MODEL

Abstract 5668: Using clinical utility index (CUI) to determine the optimal biological dose of a nonfucosylated anti-TIGIT antibody: A proposed alternative to maximum tolerated dose (MTD)

Predicting Maternal-Fetal Cannabinoid Exposure during Pregnancy Using Physiologically-Based Pharmacokinetic Modeling and Simulation

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