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Actinonin, a Naturally Occurring Antibacterial Agent, Is a Potent Deformylase Inhibitor

Biochemistry (Easton), 2000-02, Vol.39 (6), p.1256-1262

2000

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Approaches to Combinatorial Synthesis of Heterocycles: A Solid-Phase Synthesis of 1,4-Dihydropyridines

Journal of organic chemistry, 1996-02, Vol.61 (3), p.924-928

1996

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N-Alkyl Urea Hydroxamic Acids as a New Class of Peptide Deformylase Inhibitors with Antibacterial Activity

Antimicrobial Agents and Chemotherapy, 2002-09, Vol.46 (9), p.2752-2764

2002

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Pharmacokinetics and Pharmacodynamics of AR9281, an Inhibitor of Soluble Epoxide Hydrolase, in Single- and Multiple-Dose Studies in Healthy Human Subjects

Journal of clinical pharmacology, 2012-03, Vol.52 (3), p.319-328

2012

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alpha.-Hydroxy Phosphinyl-Based Inhibitors of Human Renin

Journal of medicinal chemistry, 1995-10, Vol.38 (22), p.4557-4569

1995

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Selective Solid Phase Synthesis of Ureas and Hydantoins from Common Phenyl Carbamate Intermediates

Journal of organic chemistry, 1997-10, Vol.62 (20), p.6968-6973

1997

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1-(1-Acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia

Bioorganic & medicinal chemistry letters, 2011-02, Vol.21 (3), p.983-988

2011

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N- and C-terminal modifications of negamycin

Bioorganic & medicinal chemistry letters, 2003-07, Vol.13 (14), p.2413-2418

2003

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Rational Design and Combinatorial Evaluation of Enzyme Inhibitor Scaffolds: Identification of Novel Inhibitors of Matrix Metalloproteinases

Journal of medicinal chemistry, 1998-06, Vol.41 (13), p.2194-2200

1998

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Conformationally restricted analogs of deoxynegamycin

Bioorganic & medicinal chemistry letters, 2004-06, Vol.14 (12), p.3103-3107

2004

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Non-urea functionality as the primary pharmacophore in soluble epoxide hydrolase inhibitors

Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (4), p.1066-1070

2009

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Farnesyl Diphosphate-Based Inhibitors of Ras Farnesyl Protein Transferase

Journal of medicinal chemistry, 1995-07, Vol.38 (15), p.2906-2921

1995

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Design and synthesis of thiazole-5-hydroxamic acids as novel histone deacetylase inhibitors

Bioorganic & medicinal chemistry letters, 2007-11, Vol.17 (21), p.5995-5999

2007

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Conformational Constraint in Oxazolidinone Antibacterials. Synthesis and Structure−Activity Studies of (Azabicyclo[3.1.0]hexylphenyl)oxazolidinones

Journal of medicinal chemistry, 2005-07, Vol.48 (15), p.5009-5024

2005

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Activated ketone based inhibitors of human renin

Journal of medicinal chemistry, 1993-08, Vol.36 (17), p.2431-2447

1993

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Novel oxazolidinone–quinolone hybrid antimicrobials

Bioorganic & medicinal chemistry letters, 2003-12, Vol.13 (23), p.4213-4216

2003

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Mercaptoamide-based non-hydroxamic acid type histone deacetylase inhibitors

Bioorganic & medicinal chemistry letters, 2005-04, Vol.15 (8), p.1969-1972

2005

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A New and Efficient Solid Phase Synthesis of Hydroxamic Acids

Journal of organic chemistry, 1997-10, Vol.62 (21), p.7088-7089

1997

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Synthesis and structure–activity studies of antibacterial oxazolidinones containing dihydrothiopyran or dihydrothiazine C-rings

Bioorganic & medicinal chemistry letters, 2006-07, Vol.16 (13), p.3475-3478

2006

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Approaches to combinatorial synthesis of heterocycles: Solid phase synthesis of pyridines and pyrido[2,3-d]pyrimidines

Tetrahedron letters, 1996-07, Vol.37 (27), p.4643-4646

1996

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New Antibacterial tetrahydro-4(2 H)-thiopyran and thiomorpholine S-oxide and S, S-dioxide phenyloxazolidinones

Bioorganic & medicinal chemistry letters, 2003-12, Vol.13 (23), p.4209-4212

2003

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A general and efficient solid phase synthesis of quinazoline-2,4-diones

Tetrahedron letters, 1997-03, Vol.38 (10), p.1729-1732

1997

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An Efficient Synthesis of N-α-Fmoc-4-(Phosphonodifluoromethyl)-l- phenylalanine

Journal of organic chemistry, 1996-02, Vol.61 (4), p.1537-1539

1996

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A Transition State Analog Inhibitor Combinatorial Library

Journal of the American Chemical Society, 1995-05, Vol.117 (19), p.5381-5382

1995

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Actinonin, a Naturally Occurring Antibacterial Agent, Is a Potent Deformylase Inhibitor

Approaches to Combinatorial Synthesis of Heterocycles: A Solid-Phase Synthesis of 1,4-Dihydropyridines

N-Alkyl Urea Hydroxamic Acids as a New Class of Peptide Deformylase Inhibitors with Antibacterial Activity

Pharmacokinetics and Pharmacodynamics of AR9281, an Inhibitor of Soluble Epoxide Hydrolase, in Single- and Multiple-Dose Studies in Healthy Human Subjects

alpha.-Hydroxy Phosphinyl-Based Inhibitors of Human Renin

Selective Solid Phase Synthesis of Ureas and Hydantoins from Common Phenyl Carbamate Intermediates

Discovery and Characterization of a Potent Interleukin-6 Binding Peptide with Neutralizing Activity In Vivo

1-(1-Acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia

N- and C-terminal modifications of negamycin

Rational Design and Combinatorial Evaluation of Enzyme Inhibitor Scaffolds: Identification of Novel Inhibitors of Matrix Metalloproteinases

Conformationally restricted analogs of deoxynegamycin

Non-urea functionality as the primary pharmacophore in soluble epoxide hydrolase inhibitors

Farnesyl Diphosphate-Based Inhibitors of Ras Farnesyl Protein Transferase

Design and synthesis of thiazole-5-hydroxamic acids as novel histone deacetylase inhibitors

Conformational Constraint in Oxazolidinone Antibacterials. Synthesis and Structure−Activity Studies of (Azabicyclo[3.1.0]hexylphenyl)oxazolidinones

Activated ketone based inhibitors of human renin

Novel oxazolidinone–quinolone hybrid antimicrobials

Mercaptoamide-based non-hydroxamic acid type histone deacetylase inhibitors

A New and Efficient Solid Phase Synthesis of Hydroxamic Acids

Synthesis and structure–activity studies of antibacterial oxazolidinones containing dihydrothiopyran or dihydrothiazine C-rings

Approaches to combinatorial synthesis of heterocycles: Solid phase synthesis of pyridines and pyrido[2,3-d]pyrimidines

New Antibacterial tetrahydro-4(2 H)-thiopyran and thiomorpholine S-oxide and S, S-dioxide phenyloxazolidinones

A general and efficient solid phase synthesis of quinazoline-2,4-diones

An Efficient Synthesis of N-α-Fmoc-4-(Phosphonodifluoromethyl)-l- phenylalanine

A Transition State Analog Inhibitor Combinatorial Library

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