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In silico selection of therapeutic antibodies for development: Viscosity, clearance, and chemical stability

Proceedings of the National Academy of Sciences - PNAS, 2014-12, Vol.111 (52), p.18601-18606

2014

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Auristatin Antibody Drug Conjugate Physical Instability and the Role of Drug Payload

Bioconjugate chemistry, 2014-04, Vol.25 (4), p.656-664

2014

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In vitro model for predicting bioavailability of subcutaneously injected monoclonal antibodies

Journal of controlled release, 2018-03, Vol.273, p.13-20

2018

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A novel in vitro method to model the fate of subcutaneously administered biopharmaceuticals and associated formulation components

Journal of controlled release, 2015-09, Vol.214, p.94-102

2015

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Coarse-Grained Modeling of the Self-Association of Therapeutic Monoclonal Antibodies

The journal of physical chemistry. B, 2012-07, Vol.116 (28), p.8045-8057

2012

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Protein Aggregation in Frozen Trehalose Formulations: Effects of Composition, Cooling Rate, and Storage Temperature

Journal of pharmaceutical sciences, 2015-12, Vol.104 (12), p.4170-4184

2015

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The Role of Amino Acid Sequence in the Self-Association of Therapeutic Monoclonal Antibodies: Insights from Coarse-Grained Modeling

The journal of physical chemistry. B, 2013-02, Vol.117 (5), p.1269-1279

2013

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Trehalose Limits BSA Aggregation in Spray-Dried Formulations at High Temperatures: Implications in Preparing Polymer Implants for Long-Term Protein Delivery

Journal of pharmaceutical sciences, 2013-08, Vol.102 (8), p.2655-2666

2013

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Construction, MD Simulation, and Hydrodynamic Validation of an All-Atom Model of a Monoclonal IgG Antibody

Biophysical journal, 2010-08, Vol.99 (3), p.905-913

2010

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Molecular Simulations of the Pairwise Interaction of Monoclonal Antibodies

The journal of physical chemistry. B, 2014-11, Vol.118 (46), p.13132-13141

2014

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Polysorbate 20 prevents the precipitation of a monoclonal antibody during shear

Pharmaceutical development and technology, 2009-12, Vol.14 (6), p.659-664

2009

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Multiscale Coarse-Grained Approach to Investigate Self-Association of Antibodies

Biophysical journal, 2020-06, Vol.118 (11), p.2741-2754

2020

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Opposite Effects of Polyols on Antibody Aggregation: Thermal Versus Mechanical Stresses

Pharmaceutical research, 2012-03, Vol.29 (3), p.683-694

2012

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Mutational landscape of antibody variable domains reveals a switch modulating the interdomain conformational dynamics and antigen binding

Proceedings of the National Academy of Sciences - PNAS, 2017-01, Vol.114 (4), p.E486-E495

2017

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Reversible Self-Association of a Concentrated Monoclonal Antibody Solution Mediated by Fab–Fab Interaction That Impacts Solution Viscosity

Journal of pharmaceutical sciences, 2008-10, Vol.97 (10), p.4219-4227

2008

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Cold denaturation of monoclonal antibodies

mAbs, 2010-01, Vol.2 (1), p.42-52

2010

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Crystallization of Trehalose in Frozen Solutions and its Phase Behavior during Drying

Pharmaceutical research, 2010-11, Vol.27 (11), p.2374-2383

2010

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Vibrational spectroscopy and chemometrics to characterize and quantitate trehalose crystallization

Analytical biochemistry, 2010-04, Vol.399 (1), p.48-57

2010

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Influence of glycosylation pattern on the molecular properties of monoclonal antibodies

mAbs, 2014-05, Vol.6 (3), p.649-658

2014

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Molecular simulations of micellar aggregation of polysorbate 20 ester fractions and their interaction with N-phenyl-1-naphthylamine dye

Biophysical chemistry, 2016-06, Vol.213, p.17-24

2016

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Cathepsin B Cleavage of vcMMAE-Based Antibody–Drug Conjugate Is Not Drug Location or Monoclonal Antibody Carrier Specific

Bioconjugate chemistry, 2016-04, Vol.27 (4), p.1040-1049

2016

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Split-Cakes, Still Delicious

PDA journal of pharmaceutical science and technology, 2019, Vol.73 (1), p.16-29

2019

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Hexyl Glucoside and Hexyl Maltoside Inhibit Light-Induced Oxidation of Tryptophan

Journal of pharmaceutical sciences, 2014-02, Vol.103 (2), p.409-416

2014

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Modeling of protein–anion exchange resin interaction for the human growth hormone charge variants

Biophysical chemistry, 2015-12, Vol.207, p.1-6

2015

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Characterization of antibody–polyol interactions by static light scattering: Implications for physical stability of protein formulations

International journal of pharmaceutics, 2013-05, Vol.448 (2), p.382-389

2013

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In silico selection of therapeutic antibodies for development: Viscosity, clearance, and chemical stability

Auristatin Antibody Drug Conjugate Physical Instability and the Role of Drug Payload

In vitro model for predicting bioavailability of subcutaneously injected monoclonal antibodies

A novel in vitro method to model the fate of subcutaneously administered biopharmaceuticals and associated formulation components

Coarse-Grained Modeling of the Self-Association of Therapeutic Monoclonal Antibodies

Protein Aggregation in Frozen Trehalose Formulations: Effects of Composition, Cooling Rate, and Storage Temperature

The Role of Amino Acid Sequence in the Self-Association of Therapeutic Monoclonal Antibodies: Insights from Coarse-Grained Modeling

Trehalose Limits BSA Aggregation in Spray-Dried Formulations at High Temperatures: Implications in Preparing Polymer Implants for Long-Term Protein Delivery

Construction, MD Simulation, and Hydrodynamic Validation of an All-Atom Model of a Monoclonal IgG Antibody

Molecular Simulations of the Pairwise Interaction of Monoclonal Antibodies

Polysorbate 20 prevents the precipitation of a monoclonal antibody during shear

Multiscale Coarse-Grained Approach to Investigate Self-Association of Antibodies

Opposite Effects of Polyols on Antibody Aggregation: Thermal Versus Mechanical Stresses

Mutational landscape of antibody variable domains reveals a switch modulating the interdomain conformational dynamics and antigen binding

Reversible Self-Association of a Concentrated Monoclonal Antibody Solution Mediated by Fab–Fab Interaction That Impacts Solution Viscosity

Cold denaturation of monoclonal antibodies

Crystallization of Trehalose in Frozen Solutions and its Phase Behavior during Drying

Vibrational spectroscopy and chemometrics to characterize and quantitate trehalose crystallization

Influence of glycosylation pattern on the molecular properties of monoclonal antibodies

Molecular simulations of micellar aggregation of polysorbate 20 ester fractions and their interaction with N-phenyl-1-naphthylamine dye

Cathepsin B Cleavage of vcMMAE-Based Antibody–Drug Conjugate Is Not Drug Location or Monoclonal Antibody Carrier Specific

Split-Cakes, Still Delicious

Hexyl Glucoside and Hexyl Maltoside Inhibit Light-Induced Oxidation of Tryptophan

Modeling of protein–anion exchange resin interaction for the human growth hormone charge variants

Characterization of antibody–polyol interactions by static light scattering: Implications for physical stability of protein formulations

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