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Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11

Nature chemical biology, 2017-05, Vol.13 (5), p.486-493

2017

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Tks5-dependent, nox-mediated generation of reactive oxygen species is necessary for invadopodia formation

Science signaling, 2009-09, Vol.2 (88), p.ra53

2009

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The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors

Nature communications, 2021-09, Vol.12 (1), p.5397-17, Article 5397

2021

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The novel adaptor protein Tks4 (SH3PXD2B) is required for functional podosome formation

Molecular biology of the cell, 2009-03, Vol.20 (5), p.1302-1311

2009

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Nck adaptor proteins link Tks5 to invadopodia actin regulation and ECM degradation

Journal of cell science, 2009-08, Vol.122 (15), p.2727-2740

2009

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The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells

Cancer cell, 2005-02, Vol.7 (2), p.155-165

2005

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Development of a Robust High-Throughput Screening Platform for Inhibitors of the Striatal-Enriched Tyrosine Phosphatase (STEP)

International journal of molecular sciences, 2021-04, Vol.22 (9), p.4417

2021

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Improving drug discovery using image-based multiparametric analysis of the epigenetic landscape

eLife, 2019-10, Vol.8

2019

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The Lipid Phosphatase Activity of PTEN is Critical for Its Tumor Supressor Function

Proceedings of the National Academy of Sciences - PNAS, 1998-11, Vol.95 (23), p.13513-13518

1998

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A role for the podosome/invadopodia scaffold protein Tks5 in tumor growth in vivo

European journal of cell biology, 2008-09, Vol.87 (8), p.555-567

2008

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The Adaptor Protein Fish Associates with Members of the ADAMs Family and Localizes to Podosomes of Src-transformed Cells

The Journal of biological chemistry, 2003-05, Vol.278 (19), p.16844-16851

2003

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TR-FRET-based high-throughput screening assay for identification of UBC13 inhibitors

Journal of biomolecular screening, 2012-02, Vol.17 (2), p.163-176

2012

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High-throughput screening of compounds targeting RNA editing in Trypanosoma brucei: Novel molecular scaffolds with broad trypanocidal effects

Biochemical pharmacology, 2024-01, Vol.219, p.115937, Article 115937

2024

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EPEN-26. DRUG SCREENING IN PATIENT-DERIVED MODELS OF POSTERIOR FOSSA A EPENDYMOMA REVEALS NOVEL PHARMACOLOGICAL VULNERABILITIES

Neuro-oncology (Charlottesville, Va.), 2024-06, Vol.26 (Suppl 4), p.0-0

2024

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Role of Vitronectin in the Formation of Lipid-Protein Aggregates in Age-Related Macular Degeneration

Biophysical journal, 2020-02, Vol.118 (3), p.512a-512a

2020

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Abstract C040: Discovery and development of novel ATG13 degrading compounds that inhibit autophagy and treat Non-Small Cell Lung Cancer

Molecular cancer therapeutics, 2023-12, Vol.22 (12_Supplement), p.C040-C040

2023

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Serine-Threonine Kinase TAO3-Mediated Trafficking of Endosomes Containing the Invadopodia Scaffold TKS5α Promotes Cancer Invasion and Tumor Growth

Cancer research (Chicago, Ill.), 2021-03, Vol.81 (6), p.1472-1485

2021

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RNF5 Defines Acute Myeloid Leukemia Growth and Susceptibility to Histone Deacetylase Inhibitors

Blood, 2020-11, Vol.136 (Supplement 1), p.31-32

2020

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Identification and characterization of small molecule inhibitors of the ubiquitin ligases Siah1/2 in melanoma and prostate cancer cells

Cancer letters, 2019-05, Vol.449, p.145-162

2019

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Tumor suppressor and anti-inflammatory actions of PPARγ agonists are mediated via upregulation of PTEN

Current biology, 2001-05, Vol.11 (10), p.764-768

2001

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Interfacial kinetic analysis of the tumour suppressor phosphatase, PTEN: evidence for activation by anionic phospholipids

Biochemical journal, 2003-05, Vol.371 (Pt 3), p.947-955

2003

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Cell-Based High-Throughput Luciferase Reporter Gene Assays for Identifying and Profiling Chemical Modulators of Endoplasmic Reticulum Signaling Protein, IRE1

Journal of biomolecular screening, 2015-12, Vol.20 (10), p.1232-1245

2015

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Discovery and Characterization of Chemical Inhibitors of UBC13

Blood, 2012-11, Vol.120 (21), p.2950-2950

2012

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Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes

Bioorganic & medicinal chemistry letters, 2014-02, Vol.24 (3), p.1000-1004

2014

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Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions

Biochemical journal, 2001-07, Vol.357 (Pt 2), p.427-435

2001

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Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11

Tks5-dependent, nox-mediated generation of reactive oxygen species is necessary for invadopodia formation

The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors

The novel adaptor protein Tks4 (SH3PXD2B) is required for functional podosome formation

Nck adaptor proteins link Tks5 to invadopodia actin regulation and ECM degradation

The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells

Development of a Robust High-Throughput Screening Platform for Inhibitors of the Striatal-Enriched Tyrosine Phosphatase (STEP)

Improving drug discovery using image-based multiparametric analysis of the epigenetic landscape

The Lipid Phosphatase Activity of PTEN is Critical for Its Tumor Supressor Function

A role for the podosome/invadopodia scaffold protein Tks5 in tumor growth in vivo

The Adaptor Protein Fish Associates with Members of the ADAMs Family and Localizes to Podosomes of Src-transformed Cells

TR-FRET-based high-throughput screening assay for identification of UBC13 inhibitors

High-throughput screening of compounds targeting RNA editing in Trypanosoma brucei: Novel molecular scaffolds with broad trypanocidal effects

EPEN-26. DRUG SCREENING IN PATIENT-DERIVED MODELS OF POSTERIOR FOSSA A EPENDYMOMA REVEALS NOVEL PHARMACOLOGICAL VULNERABILITIES

Role of Vitronectin in the Formation of Lipid-Protein Aggregates in Age-Related Macular Degeneration

Abstract C040: Discovery and development of novel ATG13 degrading compounds that inhibit autophagy and treat Non-Small Cell Lung Cancer

Serine-Threonine Kinase TAO3-Mediated Trafficking of Endosomes Containing the Invadopodia Scaffold TKS5α Promotes Cancer Invasion and Tumor Growth

RNF5 Defines Acute Myeloid Leukemia Growth and Susceptibility to Histone Deacetylase Inhibitors

Identification and characterization of small molecule inhibitors of the ubiquitin ligases Siah1/2 in melanoma and prostate cancer cells

Tumor suppressor and anti-inflammatory actions of PPARγ agonists are mediated via upregulation of PTEN

Interfacial kinetic analysis of the tumour suppressor phosphatase, PTEN: evidence for activation by anionic phospholipids

Cell-Based High-Throughput Luciferase Reporter Gene Assays for Identifying and Profiling Chemical Modulators of Endoplasmic Reticulum Signaling Protein, IRE1

Discovery and Characterization of Chemical Inhibitors of UBC13

Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes

Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions

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