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Is bacterial fatty acid synthesis a valid target for antibacterial drug discovery?

Current opinion in microbiology, 2011-10, Vol.14 (5), p.544-549

2011

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Membrane Disruption by Antimicrobial Fatty Acids Releases Low-Molecular-Weight Proteins from Staphylococcus aureus

Journal of Bacteriology, 2012-10, Vol.194 (19), p.5294-5304

2012

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Metabolic basis for the differential susceptibility of Gram-positive pathogens to fatty acid synthesis inhibitors

Proceedings of the National Academy of Sciences - PNAS, 2011-09, Vol.108 (37), p.15378-15383

2011

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Identification of a two-component fatty acid kinase responsible for host fatty acid incorporation by Staphylococcus aureus

Proceedings of the National Academy of Sciences - PNAS, 2014-07, Vol.111 (29), p.10532-10537

2014

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Incorporation of extracellular fatty acids by a fatty acid kinase‐dependent pathway in Staphylococcus aureus

Molecular microbiology, 2014-04, Vol.92 (2), p.234-245

2014

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Synthesis of Empty Bacterial Microcompartments, Directed Organelle Protein Incorporation, and Evidence of Filament-Associated Organelle Movement

Molecular cell, 2010-04, Vol.38 (2), p.305-315

2010

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Persistent Methicillin-Resistant Staphylococcus aureus Bacteremia: Host, Pathogen, and Treatment

Antibiotics (Basel), 2023-02, Vol.12 (3), p.455

2023

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Bacterial lipids: Metabolism and membrane homeostasis

Progress in lipid research, 2013-07, Vol.52 (3), p.249-276

2013

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Staphylococcus aureus Fatty Acid Auxotrophs Do Not Proliferate in Mice

Antimicrobial Agents and Chemotherapy, 2013-11, Vol.57 (11), p.5729-5732

2013

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Antibiotic-induced accumulation of lipid II synergizes with antimicrobial fatty acids to eradicate bacterial populations

eLife, 2023-03, Vol.12

2023

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Lactobacillus reuteri DSM 20016 Produces Cobalamin-Dependent Diol Dehydratase in Metabolosomes and Metabolizes 1,2-Propanediol by Disproportionation

Journal of Bacteriology, 2008-07, Vol.190 (13), p.4559-4567

2008

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Structure of a trimeric bacterial microcompartment shell protein, EtuB, associated with ethanol utilization in Clostridium kluyveri

Biochemical journal, 2009-10, Vol.423 (2), p.199-207

2009

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Inflammasome-mediated glucose limitation induces antibiotic tolerance in Staphylococcus aureus

iScience, 2023-10, Vol.26 (10), p.107942-107942, Article 107942

2023

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Perturbation of Staphylococcus aureus Gene Expression by the Enoyl-Acyl Carrier Protein Reductase Inhibitor AFN-1252

Antimicrobial Agents and Chemotherapy, 2013-05, Vol.57 (5), p.2182-2190

2013

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Biochemical and Structural Insights into Bacterial Organelle Form and Biogenesis

The Journal of biological chemistry, 2008-05, Vol.283 (21), p.14366-14375

2008

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Characterisation of PduS, the pdu metabolosome corrin reductase, and evidence of substructural organisation within the bacterial microcompartment

PloS one, 2010-11, Vol.5 (11), p.e14009-e14009

2010

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Hemophagocytic Lymphohistiocytosis Associated With Endocarditis: A Case Years in the Making

Circulation (New York, N.Y.), 2022-03, Vol.145 (12), p.934-939

2022

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In-patient evolution of a high-persister Escherichia coli strain with reduced in vivo antibiotic susceptibility

Proceedings of the National Academy of Sciences - PNAS, 2024-01, Vol.121 (3), p.e2314514121

2024

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Clinical and Molecular Analyses of Recurrent Gram-Negative Bloodstream Infections

Clinical infectious diseases, 2023-02, Vol.76 (3), p.e1285-e1293

2023

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Vancomycin Heteroresistance and Clinical Outcomes in Bloodstream Infections Caused by Coagulase-Negative Staphylococci

Antimicrobial agents and chemotherapy, 2020-10, Vol.64 (11)

2020

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FabH mutations confer resistance to FabF-directed antibiotics in Staphylococcus aureus

Antimicrobial agents and chemotherapy, 2015-02, Vol.59 (2), p.849-858

2015

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Association of Follow-up Blood Cultures With Mortality in Patients With Gram-Negative Bloodstream Infections: A Systematic Review and Meta-analysis

JAMA network open, 2022-09, Vol.5 (9), p.e2232576

2022

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A thioesterase bypasses the requirement for exogenous fatty acids in the plsX deletion of Streptococcus pneumoniae

Molecular microbiology, 2015-04, Vol.96 (1), p.28-41

2015

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Phosphatidylglycerol homeostasis in glycerol-phosphate auxotrophs of Staphylococcus aureus

BMC microbiology, 2013-11, Vol.13 (1), p.260-260

2013

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Discovery of novel bacterial elongation condensing enzyme inhibitors by virtual screening

Bioorganic & medicinal chemistry letters, 2014-06, Vol.24 (11), p.2585-2588

2014

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Is bacterial fatty acid synthesis a valid target for antibacterial drug discovery?

Membrane Disruption by Antimicrobial Fatty Acids Releases Low-Molecular-Weight Proteins from Staphylococcus aureus

Metabolic basis for the differential susceptibility of Gram-positive pathogens to fatty acid synthesis inhibitors

Identification of a two-component fatty acid kinase responsible for host fatty acid incorporation by Staphylococcus aureus

Incorporation of extracellular fatty acids by a fatty acid kinase‐dependent pathway in Staphylococcus aureus

Synthesis of Empty Bacterial Microcompartments, Directed Organelle Protein Incorporation, and Evidence of Filament-Associated Organelle Movement

Persistent Methicillin-Resistant Staphylococcus aureus Bacteremia: Host, Pathogen, and Treatment

Bacterial lipids: Metabolism and membrane homeostasis

Staphylococcus aureus Fatty Acid Auxotrophs Do Not Proliferate in Mice

Antibiotic-induced accumulation of lipid II synergizes with antimicrobial fatty acids to eradicate bacterial populations

Lactobacillus reuteri DSM 20016 Produces Cobalamin-Dependent Diol Dehydratase in Metabolosomes and Metabolizes 1,2-Propanediol by Disproportionation

Structure of a trimeric bacterial microcompartment shell protein, EtuB, associated with ethanol utilization in Clostridium kluyveri

Inflammasome-mediated glucose limitation induces antibiotic tolerance in Staphylococcus aureus

Perturbation of Staphylococcus aureus Gene Expression by the Enoyl-Acyl Carrier Protein Reductase Inhibitor AFN-1252

Biochemical and Structural Insights into Bacterial Organelle Form and Biogenesis

Characterisation of PduS, the pdu metabolosome corrin reductase, and evidence of substructural organisation within the bacterial microcompartment

Hemophagocytic Lymphohistiocytosis Associated With Endocarditis: A Case Years in the Making

In-patient evolution of a high-persister Escherichia coli strain with reduced in vivo antibiotic susceptibility

Clinical and Molecular Analyses of Recurrent Gram-Negative Bloodstream Infections

Vancomycin Heteroresistance and Clinical Outcomes in Bloodstream Infections Caused by Coagulase-Negative Staphylococci

FabH mutations confer resistance to FabF-directed antibiotics in Staphylococcus aureus

Association of Follow-up Blood Cultures With Mortality in Patients With Gram-Negative Bloodstream Infections: A Systematic Review and Meta-analysis

A thioesterase bypasses the requirement for exogenous fatty acids in the plsX deletion of Streptococcus pneumoniae

Phosphatidylglycerol homeostasis in glycerol-phosphate auxotrophs of Staphylococcus aureus

Discovery of novel bacterial elongation condensing enzyme inhibitors by virtual screening

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