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Memantine is a clinically well tolerated N-methyl- d-aspartate (NMDA) receptor antagonist—a review of preclinical data

Neuropharmacology, 1999-06, Vol.38 (6), p.735-767

1999

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NMDA receptors as targets for drug action in neuropathic pain

European Journal of Pharmacology, 2001-10, Vol.429 (1), p.71-78

Parsons, Chris G

2001

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Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system - too little activation is bad, too much is even worse

Neuropharmacology, 2007-11, Vol.53 (6), p.699-723

2007

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Comparison of the potency, kinetics and voltage-dependency of a series of uncompetitive NMDA receptor antagonists in vitro with anticonvulsive and motor impairment activity in vivo

Neuropharmacology, 1995-10, Vol.34 (10), p.1239-1258

1995

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The NMDA receptor antagonist memantine as a symptomatological and neuroprotective treatment for Alzheimer's disease: preclinical evidence

International journal of geriatric psychiatry, 2003-09, Vol.18 (S1), p.S23-S32

2003

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Flupirtine shows functional NMDA receptor antagonism by enhancing Mg2+ block via activation of voltage independent potassium channels

Journal of neural transmission, 1999, Vol.106 (9-10), p.857-867

1999

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Uncompetitive NMDA receptor antagonists attenuate NMDA-induced impairment of passive avoidance learning and LTP

Neuropharmacology, 1997-07, Vol.36 (7), p.961-971

1997

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Glycine and N-methyl-D-aspartate receptors: physiological significance and possible therapeutic applications

Pharmacological reviews, 1998-12, Vol.50 (4), p.597

1998

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Pharmacodynamics of Memantine: An Update

Current neuropharmacology, 2008-03, Vol.6 (1), p.55-78

2008

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Amino-alkyl-cyclohexanes as a novel class of uncompetitive NMDA receptor antagonists

Current pharmaceutical design, 2002-01, Vol.8 (10), p.835

2002

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The N-methyl-D-aspartate receptor channel blockers memantine, mrz 2/579 and other amino-alkyl-cyclohexanes antagonise 5-HT3 receptor currents in cultured HEK-293 and N1E-115 cell systems in a non-competitive manner

Neuroscience letters, 2001-06, Vol.306 (1-2), p.81-84

2001

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Aminoadamantanes as NMDA receptor antagonists and antiparkinsonian agents — preclinical studies

Neuroscience and biobehavioral reviews, 1997, Vol.21 (4), p.455-468

1997

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Expression of Polyglutamine-expanded Huntingtin Induces Tyrosine Phosphorylation of N-Methyl-D-aspartate Receptors

The Journal of biological chemistry, 2003-08, Vol.278 (35), p.33364-33369

2003

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The antiallodynic effect of NMDA antagonists in neuropathic pain outlasts the duration of the in vivo NMDA antagonism

Neuropharmacology, 2006-07, Vol.51 (1), p.12-17

2006

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Memantine restores long term potentiation impaired by tonic N-methyl-D-aspartate (NMDA) receptor activation following reduction of Mg2+ in hippocampal slices

Neuropharmacology, 1999-09, Vol.38 (9), p.1253-1259

1999

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Orphenadrine is an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist : binding and patch clamp studies

Journal of Neural Transmission, 1995-01, Vol.102 (3), p.237-246

1995

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A Novel Series of 2-Carboxytetrahydroquinolines Provides New Insights into the Eastern Region of Glycine Site NMDA Antagonists

Archiv der Pharmazie (Weinheim), 2000-08, Vol.333 (8), p.267-274

2000

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Amino-alkyl-cyclohexanes are novel uncompetitive NMDA receptor antagonists with strong voltage-dependency and fast blocking kinetics: in vitro and in vivo characterization

Neuropharmacology, 1999, Vol.38 (1), p.85-108

1999

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Patch clamp studies on the kinetics and selectivity of N-methyl-D-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan)

Neuropharmacology, 1993-12, Vol.32 (12), p.1337-1350

1993

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Novel systemically active antagonists of the glycine site of the N-methyl-D-aspartate receptor: electrophysiological, biochemical and behavioral characterization

The Journal of pharmacology and experimental therapeutics, 1997-12, Vol.283 (3), p.1264

1997

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N-Methyl- d-Aspartate Receptors Mediate Endogenous Opioid Release in Enteric Neurons After Abdominal Surgery

Gastroenterology (New York, N.Y. 1943), 2005-06, Vol.128 (7), p.2009-2019

2005

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Peripherally acting NMDA receptor/glycine site receptor antagonists inhibit morphine tolerance

Neuropharmacology, 2005-03, Vol.48 (3), p.360-371

2005

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Effects of the Uncompetitive NMDA Receptor Antagonist Memantine on Hippocampal Long-term Potentiation, Short-term Exploratory Modulation and Spatial Memory in Awake, Freely Moving Rats

The European journal of neuroscience, 1996-03, Vol.8 (3), p.565-571

1996

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Are neuronal nicotinic receptors a target for antiepileptic drug development? Studies in different seizure models in mice and rats

European journal of pharmacology, 2003-04, Vol.466 (1), p.99-111

2003

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New Allosteric Modulators of Metabotropic Glutamate Receptor 5 (mGluR5) Found by Ligand-Based Virtual Screening

Chembiochem : a European journal of chemical biology, 2005-04, Vol.6 (4), p.620-625

2005

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Memantine is a clinically well tolerated N-methyl- d-aspartate (NMDA) receptor antagonist—a review of preclinical data

NMDA receptors as targets for drug action in neuropathic pain

Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system - too little activation is bad, too much is even worse

Comparison of the potency, kinetics and voltage-dependency of a series of uncompetitive NMDA receptor antagonists in vitro with anticonvulsive and motor impairment activity in vivo

The NMDA receptor antagonist memantine as a symptomatological and neuroprotective treatment for Alzheimer's disease: preclinical evidence

Flupirtine shows functional NMDA receptor antagonism by enhancing Mg2+ block via activation of voltage independent potassium channels

Uncompetitive NMDA receptor antagonists attenuate NMDA-induced impairment of passive avoidance learning and LTP

Glycine and N-methyl-D-aspartate receptors: physiological significance and possible therapeutic applications

Pharmacodynamics of Memantine: An Update

Amino-alkyl-cyclohexanes as a novel class of uncompetitive NMDA receptor antagonists

The N-methyl-D-aspartate receptor channel blockers memantine, mrz 2/579 and other amino-alkyl-cyclohexanes antagonise 5-HT3 receptor currents in cultured HEK-293 and N1E-115 cell systems in a non-competitive manner

Aminoadamantanes as NMDA receptor antagonists and antiparkinsonian agents — preclinical studies

Expression of Polyglutamine-expanded Huntingtin Induces Tyrosine Phosphorylation of N-Methyl-D-aspartate Receptors

The antiallodynic effect of NMDA antagonists in neuropathic pain outlasts the duration of the in vivo NMDA antagonism

Memantine restores long term potentiation impaired by tonic N-methyl-D-aspartate (NMDA) receptor activation following reduction of Mg2+ in hippocampal slices

Orphenadrine is an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist : binding and patch clamp studies

A Novel Series of 2-Carboxytetrahydroquinolines Provides New Insights into the Eastern Region of Glycine Site NMDA Antagonists

Amino-alkyl-cyclohexanes are novel uncompetitive NMDA receptor antagonists with strong voltage-dependency and fast blocking kinetics: in vitro and in vivo characterization

Patch clamp studies on the kinetics and selectivity of N-methyl-D-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan)

Novel systemically active antagonists of the glycine site of the N-methyl-D-aspartate receptor: electrophysiological, biochemical and behavioral characterization

N-Methyl- d-Aspartate Receptors Mediate Endogenous Opioid Release in Enteric Neurons After Abdominal Surgery

Peripherally acting NMDA receptor/glycine site receptor antagonists inhibit morphine tolerance

Effects of the Uncompetitive NMDA Receptor Antagonist Memantine on Hippocampal Long-term Potentiation, Short-term Exploratory Modulation and Spatial Memory in Awake, Freely Moving Rats

Are neuronal nicotinic receptors a target for antiepileptic drug development? Studies in different seizure models in mice and rats

New Allosteric Modulators of Metabotropic Glutamate Receptor 5 (mGluR5) Found by Ligand-Based Virtual Screening

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