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Preclinical Safety Assessments of UC781 Anti-Human Immunodeficiency Virus Topical Microbicide Formulations

Antimicrobial Agents and Chemotherapy, 2007-05, Vol.51 (5), p.1608-1615

2007

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Hybrids of RNA and Arabinonucleic Acids (ANA and 2‘F-ANA) Are Substrates of Ribonuclease H

Journal of the American Chemical Society, 1998-12, Vol.120 (49), p.12976-12977

1998

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Molecular mechanisms of HIV-1 resistance to nucleoside reverse transcriptase inhibitors (NRTIs)

Cellular and molecular life sciences : CMLS, 2000-09, Vol.57 (10), p.1408-1422

2000

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The same mutation that encodes low-level human immunodeficiency virus type 1 resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine confers high-level resistance to the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidine

Antimicrobial Agents and Chemotherapy, 1993-06, Vol.37 (6), p.1390-1392

1993

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Identification of a mutation at codon 65 in the IKKK motif of reverse transcriptase that encodes human immunodeficiency virus resistance to 2',3'-dideoxycytidine and 2',3'-dideoxy-3'-thiacytidine

Antimicrobial Agents and Chemotherapy, 1994-02, Vol.38 (2), p.275-281

1994

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Novel mutation in the human immunodeficiency virus type 1 reverse transcriptase gene that encodes cross-resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine

Journal of Virology, 1992-12, Vol.66 (12), p.7128-7135

1992

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Effect of translocation defective reverse transcriptase inhibitors on the activity of N348I, a connection subdomain drug resistant HIV-1 reverse transcriptase mutant

Cellular and molecular biology (Noisy-le-Grand, France), 2012-12, Vol.58 (1), p.187-195

2012

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Comparison of deoxyoligonucleotide and tRNA(Lys-3) as primers in an endogenous human immunodeficiency virus-1 in vitro reverse transcription/template-switching reaction

The Journal of biological chemistry, 1994-05, Vol.269 (20), p.14672-14680

1994

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Chemical barriers to human immunodeficiency virus type 1 (HIV-1) infection: retrovirucidal activity of UC781, a thiocarboxanilide nonnucleoside inhibitor of HIV-1 reverse transcriptase

Journal of Virology, 1997-04, Vol.71 (4), p.3023-3030

1997

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Phenotypic Mechanism of HIV-1 Resistance to 3‘-Azido-3‘-deoxythymidine (AZT): Increased Polymerization Processivity and Enhanced Sensitivity to Pyrophosphate of the Mutant Viral Reverse Transcriptase

Biochemistry (Easton), 1998-11, Vol.37 (45), p.15908-15917

1998

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The Thiocarboxanilide Nonnucleoside Inhibitor UC781 Restores Antiviral Activity of 3′-Azido-3′-Deoxythymidine (AZT) against AZT-Resistant Human Immunodeficiency Virus Type 1

Antimicrobial Agents and Chemotherapy, 1999-02, Vol.43 (2), p.259-263

1999

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The sugar ring conformation of 4'-ethynyl-2-fluoro-2'-deoxyadenosine and its recognition by the polymerase active site of HIV reverse transcriptase

Cellular and molecular biology (Noisy-le-Grand, France), 2011-02, Vol.57 (1), p.40-46

2011

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Inhibition of the Ribonuclease H and DNA Polymerase Activities of HIV-1 Reverse Transcriptase by N-(4-tert-Butylbenzoyl)-2-hydroxy-1-naphthaldehyde Hydrazone

Biochemistry (Easton), 1997-03, Vol.36 (11), p.3179-3185

1997

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Human immunodeficiency virus Type 1 nucleocapsid protein (NCp7) directs specific initiation of minus-strand DNA synthesis primed by human tRNA(Lys3) in vitro: studies of viral RNA molecules mutated in regions that flank the primer binding site

Journal of Virology, 1996-08, Vol.70 (8), p.4996-5004

1996

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In vitro selection of variants of human immunodeficiency virus type 1 resistant to 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine

Journal of Virology, 1992-01, Vol.66 (1), p.12-19

1992

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The M184V Mutation in the Reverse Transcriptase of Human Immunodeficiency Virus Type 1 Impairs Rescue of Chain-Terminated DNA Synthesis

Journal of Virology, 2000-04, Vol.74 (8), p.3579-3585

2000

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Effects of alterations of primer-binding site sequences on human immunodeficiency virus type 1 replication

Journal of Virology, 1994-10, Vol.68 (10), p.6198-6206

1994

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Missense mutations in the phenylalanine hydroxylase gene (PAH) can cause accelerated proteolytic turnover of PAH enzyme: A mechanism underlying phenylketonuria

Journal of inherited metabolic disease, 1999-05, Vol.22 (3), p.208-212

1999

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The K65R mutant reverse transcriptase of HIV-1 cross-resistant to 2', 3'-dideoxycytidine, 2',3'-dideoxy-3'-thiacytidine, and 2',3'-dideoxyinosine shows reduced sensitivity to specific dideoxynucleoside triphosphate inhibitors in vitro

The Journal of biological chemistry, 1994-11, Vol.269 (45), p.28118-28122

1994

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Mutated K65R Recombinant Reverse Transcriptase of Human Immunodeficiency Virus Type 1 Shows Diminished Chain Termination in the Presence of 2',3'- Dideoxycytidine 5'-Triphosphate and Other Drugs

Proceedings of the National Academy of Sciences - PNAS, 1995-03, Vol.92 (7), p.2760-2764

1995

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Effect of mutations in the nucleocapsid protein (NCp7) upon Pr160(gag-pol) and tRNA(Lys) incorporation into human immunodeficiency virus type 1

Journal of Virology, 1997-06, Vol.71 (6), p.4378-4384

1997

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Enhanced Fidelity of 3TC-Selected Mutant HIV-1 Reverse Transcriptase

Science (American Association for the Advancement of Science), 1996-03, Vol.271 (5253), p.1282-1285

1996

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Effectiveness of 3TC in HIV clinical trials may be due in part to the M184V substitution in 3TC-resistant HIV-1 reverse transcriptase

AIDS (London), 1996-12, Vol.10, p.S3-S10

1996

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Biological comparison of wild-type and zidovudine-resistant isolates of human immunodeficiency virus type 1 from the same subjects: susceptibility and resistance to other drugs

Antimicrobial Agents and Chemotherapy, 1991-05, Vol.35 (5), p.988-991

1991

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Mechanism of inhibition of HIV-1 infection in Vitro by purified extract of Prunella vulgaris

Virology (New York, N.Y.), 1992-03, Vol.187 (1), p.56-62

1992

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Preclinical Safety Assessments of UC781 Anti-Human Immunodeficiency Virus Topical Microbicide Formulations

Hybrids of RNA and Arabinonucleic Acids (ANA and 2‘F-ANA) Are Substrates of Ribonuclease H

Molecular mechanisms of HIV-1 resistance to nucleoside reverse transcriptase inhibitors (NRTIs)

The same mutation that encodes low-level human immunodeficiency virus type 1 resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine confers high-level resistance to the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidine

Identification of a mutation at codon 65 in the IKKK motif of reverse transcriptase that encodes human immunodeficiency virus resistance to 2',3'-dideoxycytidine and 2',3'-dideoxy-3'-thiacytidine

Novel mutation in the human immunodeficiency virus type 1 reverse transcriptase gene that encodes cross-resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine

Effect of translocation defective reverse transcriptase inhibitors on the activity of N348I, a connection subdomain drug resistant HIV-1 reverse transcriptase mutant

Comparison of deoxyoligonucleotide and tRNA(Lys-3) as primers in an endogenous human immunodeficiency virus-1 in vitro reverse transcription/template-switching reaction

Chemical barriers to human immunodeficiency virus type 1 (HIV-1) infection: retrovirucidal activity of UC781, a thiocarboxanilide nonnucleoside inhibitor of HIV-1 reverse transcriptase

Phenotypic Mechanism of HIV-1 Resistance to 3‘-Azido-3‘-deoxythymidine (AZT): Increased Polymerization Processivity and Enhanced Sensitivity to Pyrophosphate of the Mutant Viral Reverse Transcriptase

The Thiocarboxanilide Nonnucleoside Inhibitor UC781 Restores Antiviral Activity of 3′-Azido-3′-Deoxythymidine (AZT) against AZT-Resistant Human Immunodeficiency Virus Type 1

The sugar ring conformation of 4'-ethynyl-2-fluoro-2'-deoxyadenosine and its recognition by the polymerase active site of HIV reverse transcriptase

Inhibition of the Ribonuclease H and DNA Polymerase Activities of HIV-1 Reverse Transcriptase by N-(4-tert-Butylbenzoyl)-2-hydroxy-1-naphthaldehyde Hydrazone

Human immunodeficiency virus Type 1 nucleocapsid protein (NCp7) directs specific initiation of minus-strand DNA synthesis primed by human tRNA(Lys3) in vitro: studies of viral RNA molecules mutated in regions that flank the primer binding site

In vitro selection of variants of human immunodeficiency virus type 1 resistant to 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine

The M184V Mutation in the Reverse Transcriptase of Human Immunodeficiency Virus Type 1 Impairs Rescue of Chain-Terminated DNA Synthesis

Effects of alterations of primer-binding site sequences on human immunodeficiency virus type 1 replication

Missense mutations in the phenylalanine hydroxylase gene (PAH) can cause accelerated proteolytic turnover of PAH enzyme: A mechanism underlying phenylketonuria

The K65R mutant reverse transcriptase of HIV-1 cross-resistant to 2', 3'-dideoxycytidine, 2',3'-dideoxy-3'-thiacytidine, and 2',3'-dideoxyinosine shows reduced sensitivity to specific dideoxynucleoside triphosphate inhibitors in vitro

Mutated K65R Recombinant Reverse Transcriptase of Human Immunodeficiency Virus Type 1 Shows Diminished Chain Termination in the Presence of 2',3'- Dideoxycytidine 5'-Triphosphate and Other Drugs

Effect of mutations in the nucleocapsid protein (NCp7) upon Pr160(gag-pol) and tRNA(Lys) incorporation into human immunodeficiency virus type 1

Enhanced Fidelity of 3TC-Selected Mutant HIV-1 Reverse Transcriptase

Effectiveness of 3TC in HIV clinical trials may be due in part to the M184V substitution in 3TC-resistant HIV-1 reverse transcriptase

Biological comparison of wild-type and zidovudine-resistant isolates of human immunodeficiency virus type 1 from the same subjects: susceptibility and resistance to other drugs

Mechanism of inhibition of HIV-1 infection in Vitro by purified extract of Prunella vulgaris

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