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Pharmacogenetic neuronal stimulation increases human tau pathology and trans-synaptic spread of tau to distal brain regions in mice

Neurobiology of disease, 2018-10, Vol.118, p.161-176

2018

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Palmitoylethanolamide Increases after Focal Cerebral Ischemia and Potentiates Microglial Cell Motility

The Journal of neuroscience, 2003-08, Vol.23 (21), p.7767-7775

2003

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Increased Severity of Stroke in CB1 Cannabinoid Receptor Knock-Out Mice

The Journal of neuroscience, 2002-11, Vol.22 (22), p.9771-9775

2002

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Geldanamycin induces heat shock proteins in brain and protects against focal cerebral ischemia

Journal of neurochemistry, 2002-04, Vol.81 (2), p.355-364

2002

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Defective Adult Neurogenesis in CB1 Cannabinoid Receptor Knockout Mice

Molecular pharmacology, 2004-08, Vol.66 (2), p.204-208

2004

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Antisense Oligodeoxynucleotide to Inducible Nitric Oxide Synthase Protects Against Transient Focal Cerebral Ischemia-Induced Brain Injury

Journal of cerebral blood flow and metabolism, 2001-01, Vol.21 (1), p.15-21

2001

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Modulation by Nitric Oxide of Cerebral Neutrophil Accumulation After Transient Focal Ischemia in Rats

Journal of cerebral blood flow and metabolism, 2000-05, Vol.20 (5), p.812-819

2000

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DNA Microarray Analysis of Cannabinoid Signaling in Mouse Brain in Vivo

Molecular pharmacology, 2002-10, Vol.62 (4), p.828-835

2002

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Internalized Tau Oligomers Cause Neurodegeneration by Inducing Accumulation of Pathogenic Tau in Human Neurons Derived from Induced Pluripotent Stem Cells

The Journal of neuroscience, 2015-10, Vol.35 (42), p.14234-14250

2015

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Astrocytic expression of the Alzheimer’s disease risk allele, ApoEε4, potentiates neuronal tau pathology in multiple preclinical models

Scientific reports, 2021-02, Vol.11 (1), p.3438-18, Article 3438

2021

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Tau-tubulin kinase 1 phosphorylates TDP-43 at disease-relevant sites and exacerbates TDP-43 pathology

Neurobiology of disease, 2021-12, Vol.161, p.105548-105548, Article 105548

2021

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POTENTIATION OF TAU PATHOLOGY BY THE APOEε4 DEMENTIA RISK ALLELE

Alzheimer's & dementia, 2017-07, Vol.13 (7), p.P1299-P1300

2017

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PHENOTYPIC SCREENING FOR NOVEL INHIBITORS OF TAU AGGREGATION IN HUMAN IPSC-DERIVED NEURONS

Alzheimer's & dementia, 2017-07, Vol.13 (7), p.P963-P964

2017

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Differential effects of the mGluR5 positive allosteric modulator CDPPB in the cortex and striatum following repeated administration

Neuropharmacology, 2012-03, Vol.62 (3), p.1453-1460

2012

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Attenuation of scratch‐induced reactive astrogliosis by novel EphA4 kinase inhibitors

Journal of neurochemistry, 2011-09, Vol.118 (6), p.1016-1031

2011

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NOVEL TARGETS FOR BLOCKING THE UPTAKE OF TAU OLIGOMERS IN HIPSC NEURONS

Alzheimer's & dementia, 2018-07, Vol.14 (7), p.P1140-P1141

2018

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P3‐192: NOVEL TARGETS FOR BLOCKING THE UPTAKE OF TAU OLIGOMERS IN HIPSC NEURONS

Alzheimer's & dementia, 2018-07, Vol.14 (7S_Part_21), p.P1140-P1141

2018

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Dose-dependent effect of CDPPB, the mGluR5 positive allosteric modulator, on recognition memory is associated with GluR1 and CREB phosphorylation in the prefrontal cortex and hippocampus

Neuropharmacology, 2009-10, Vol.57 (5), p.531-538

2009

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P3‐006: Models of tau pathology in induced pluripotent stem cell‐derived human neurons

Alzheimer's & dementia, 2015-07, Vol.11 (7S_Part_13), p.P621-P621

2015

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Iterative Focused Screening with Biological Fingerprints Identifies Selective Asc‑1 Inhibitors Distinct from Traditional High Throughput Screening

ACS chemical biology, 2017-02, Vol.12 (2), p.519-527

2017

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Models of tau pathology in induced pluripotent stem cell-derived human neurons

Alzheimer's & dementia, 2015-07, Vol.11 (7), p.P621-P621

2015

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Pharmacogenetic neuronal stimulation increases human tau pathology and trans-synaptic spread of tau to distal brain regions in mice

The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents

Palmitoylethanolamide Increases after Focal Cerebral Ischemia and Potentiates Microglial Cell Motility

Increased Severity of Stroke in CB1 Cannabinoid Receptor Knock-Out Mice

Geldanamycin induces heat shock proteins in brain and protects against focal cerebral ischemia

Defective Adult Neurogenesis in CB1 Cannabinoid Receptor Knockout Mice

Antisense Oligodeoxynucleotide to Inducible Nitric Oxide Synthase Protects Against Transient Focal Cerebral Ischemia-Induced Brain Injury

Modulation by Nitric Oxide of Cerebral Neutrophil Accumulation After Transient Focal Ischemia in Rats

DNA Microarray Analysis of Cannabinoid Signaling in Mouse Brain in Vivo

The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(t e trahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4- o n e) enhances synaptic plasticity and cognitive function in rodents

The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3 S,4 S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2 H-pyran-4-yl)-1,5-dihydro-4 H-pyrazolo[3,4- d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents

Internalized Tau Oligomers Cause Neurodegeneration by Inducing Accumulation of Pathogenic Tau in Human Neurons Derived from Induced Pluripotent Stem Cells

Astrocytic expression of the Alzheimer’s disease risk allele, ApoEε4, potentiates neuronal tau pathology in multiple preclinical models

Tau-tubulin kinase 1 phosphorylates TDP-43 at disease-relevant sites and exacerbates TDP-43 pathology

POTENTIATION OF TAU PATHOLOGY BY THE APOEε4 DEMENTIA RISK ALLELE

PHENOTYPIC SCREENING FOR NOVEL INHIBITORS OF TAU AGGREGATION IN HUMAN IPSC-DERIVED NEURONS

Differential effects of the mGluR5 positive allosteric modulator CDPPB in the cortex and striatum following repeated administration

Attenuation of scratch‐induced reactive astrogliosis by novel EphA4 kinase inhibitors

NOVEL TARGETS FOR BLOCKING THE UPTAKE OF TAU OLIGOMERS IN HIPSC NEURONS

P3‐192: NOVEL TARGETS FOR BLOCKING THE UPTAKE OF TAU OLIGOMERS IN HIPSC NEURONS

Dose-dependent effect of CDPPB, the mGluR5 positive allosteric modulator, on recognition memory is associated with GluR1 and CREB phosphorylation in the prefrontal cortex and hippocampus

Mechanism based neurotoxicity of mGlu5 positive allosteric modulators – Development challenges for a promising novel antipsychotic target

P3‐006: Models of tau pathology in induced pluripotent stem cell‐derived human neurons

Iterative Focused Screening with Biological Fingerprints Identifies Selective Asc‑1 Inhibitors Distinct from Traditional High Throughput Screening

Models of tau pathology in induced pluripotent stem cell-derived human neurons

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