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In vitro metabolism of zatosetron. Interspecies comparison and role of CYP 3A

Drug metabolism and disposition, 1994-05, Vol.22 (3), p.352

1994

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Antagonism of serotonin3 (5-HT3) receptors within the blood-brain barrier prevents cisplatin-induced emesis in dogs

The Journal of pharmacology and experimental therapeutics, 1995-05, Vol.273 (2), p.695

1995

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Evaluation of LY203647 on cardiovascular leukotriene D4 receptors and myocardial reperfusion injury

The Journal of pharmacology and experimental therapeutics, 1992-03, Vol.260 (3), p.979

1992

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Antagonism of leukotriene B4 receptors does not limit canine myocardial infarct size

The Journal of pharmacology and experimental therapeutics, 1990-04, Vol.253 (1), p.58

1990

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Metabolism, disposition, and pharmacokinetics of a potent anticonvulsant, 4-amino-N-(2,6-dimethylphenyl)benzamide (LY201116), in rats

Drug metabolism and disposition, 1989-11, Vol.17 (6), p.656

1989

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Preclinical studies on LY237733, a potent and selective serotonergic antagonist

The Journal of pharmacology and experimental therapeutics, 1992-01, Vol.260 (1), p.51

1992

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Preclinical pharmacology of a new serotonergic receptor antagonist, LY281067

The Journal of pharmacology and experimental therapeutics, 1988-01, Vol.244 (1), p.106

1988

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5-Hydroxytryptamine2 receptor antagonist activity of the acid metabolite (1-isopropyl dihydrolysergic acid) of the ergoline ester, sergolexole (LY281067)

The Journal of pharmacology and experimental therapeutics, 1989-12, Vol.251 (3), p.1006

1989

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Metabolism of the prodrug DEGA (N-(2,6-dimethylphenyl)-4-[[(diethylamino)acetyl]amino]benzamide) to the potent anticonvulsant LY201116 in mice. Effect of bis-(p-nitrophenyl)phosphate

Drug metabolism and disposition, 1988-09, Vol.16 (5), p.707

1988

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Single-Dose and Steady-State Pharmacokinetics of Tomoxetine in Normal Subjects

Journal of clinical pharmacology, 1985-05, Vol.25 (4), p.296-301

1985

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Synthesis and pharmacological evaluation of a major metabolite of ameltolide, a potent anticonvulsant

Journal of medicinal chemistry, 1991-04, Vol.34 (4), p.1253-1257

1991

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Discovery and anticonvulsant activity of the potent metabolic inhibitor 4-amino-N-(2,6-dimethylphenyl)-3,5-dimethylbenzamide

Journal of medicinal chemistry, 1987-10, Vol.30 (10), p.1742-1746

1987

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Electrophysiologic and antiarrhythmic activities of 4-amino-N-[2-(diethylamino)ethyl]-3,5-dimethylbenzamide, a sterically hindered procainamide analog

Journal of medicinal chemistry, 1988-07, Vol.31 (7), p.1290-1295

1988

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The mechanism of microsomal deamination: heavy isotope studies

Drug metabolism and disposition, 1973-01, Vol.1 (1), p.337

1973

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The enzymatic N-hydroxylation of an imine. A new cytochrome P-450-dependent reaction catalyzed by hepatic microsomal monooxygenases

The Journal of biological chemistry, 1971-11, Vol.246 (22), p.6953-6955

1971

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The relationship between the metabolism of 2,4-dichloro-6-phenylphenoxyethylamine (DPEA) and related compounds and their activities as microsomal mono-oxygenase inhibitors

Drug metabolism and disposition, 1973-07, Vol.1 (4), p.628

1973

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Metabolism of 6-chlorotryptophan to 4-chloro-3-hydroxyanthranilic acid: A potent inhibitor of 3-hydroxyanthranilic acid oxidase

Archives of biochemistry and biophysics, 1980-08, Vol.203 (1), p.161-166

1980

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Effects of microsomal mono-oxygenase inhibitors upon the in vivo metabolism and duration of action of 1-ethynylcyclohexyl carbamate

The Journal of pharmacology and experimental therapeutics, 1972-03, Vol.180 (3), p.791

1972

Volltextzugriff (PDF)

Subchronic toxicity, metabolism, and pharmacokinetics of the aminobenzamide anticonvulsant ameltolide (LY201116) in rhesus monkeys

Fundamental and applied toxicology, 1992-08, Vol.19 (2), p.197-201

1992

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Inhibition of drug metabolism by fluoxetine

Research communications in chemical pathology and pharmacology, 1976-02, Vol.13 (2), p.353

1976

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Metabolism of para-chloroamphetamine in rats

Psychopharmacology bulletin, 1976-07, Vol.12 (3), p.54

Parli, C J

1976

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Analysis of the Enantiomers of Fluoxetine and Norfluoxetine in Plasma and Tissue Using Chiral Derivatization and Normal-Phase Liquid Chromatography

Journal of liquid chromatography, 1992-03, Vol.15 (4), p.665-681

1992

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Pyruvate metabolism in mammalian liver

The American journal of physiology, 1969-06, Vol.216 (6), p.1525-1533

1969

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Induction of drug metabolism. IV. Relative abilities of polycyclic hydrocarbons to increase levels of microsomal 3-methyl-4-methylaminoazobenzene N-demethylase activity and cytochrome P1-450

Molecular pharmacology, 1970-03, Vol.6 (2), p.178-183

1970

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Comparison of the oxime and the hydroxylamine derivatives of 4-chloroamphetamine as depletors of brain 5-hydroxyindoles

Biochemical pharmacology, 1974-12, Vol.23 (23), p.3267-3272

1974

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In vitro metabolism of zatosetron. Interspecies comparison and role of CYP 3A

Antagonism of serotonin3 (5-HT3) receptors within the blood-brain barrier prevents cisplatin-induced emesis in dogs

Evaluation of LY203647 on cardiovascular leukotriene D4 receptors and myocardial reperfusion injury

Antagonism of leukotriene B4 receptors does not limit canine myocardial infarct size

Metabolism, disposition, and pharmacokinetics of a potent anticonvulsant, 4-amino-N-(2,6-dimethylphenyl)benzamide (LY201116), in rats

Preclinical studies on LY237733, a potent and selective serotonergic antagonist

Preclinical pharmacology of a new serotonergic receptor antagonist, LY281067

5-Hydroxytryptamine2 receptor antagonist activity of the acid metabolite (1-isopropyl dihydrolysergic acid) of the ergoline ester, sergolexole (LY281067)

Metabolism of the prodrug DEGA (N-(2,6-dimethylphenyl)-4-[[(diethylamino)acetyl]amino]benzamide) to the potent anticonvulsant LY201116 in mice. Effect of bis-(p-nitrophenyl)phosphate

Single-Dose and Steady-State Pharmacokinetics of Tomoxetine in Normal Subjects

Synthesis and pharmacological evaluation of a major metabolite of ameltolide, a potent anticonvulsant

Discovery and anticonvulsant activity of the potent metabolic inhibitor 4-amino-N-(2,6-dimethylphenyl)-3,5-dimethylbenzamide

Electrophysiologic and antiarrhythmic activities of 4-amino-N-[2-(diethylamino)ethyl]-3,5-dimethylbenzamide, a sterically hindered procainamide analog

The mechanism of microsomal deamination: heavy isotope studies

The enzymatic N-hydroxylation of an imine. A new cytochrome P-450-dependent reaction catalyzed by hepatic microsomal monooxygenases

The relationship between the metabolism of 2,4-dichloro-6-phenylphenoxyethylamine (DPEA) and related compounds and their activities as microsomal mono-oxygenase inhibitors

Metabolism of 6-chlorotryptophan to 4-chloro-3-hydroxyanthranilic acid: A potent inhibitor of 3-hydroxyanthranilic acid oxidase

Effects of microsomal mono-oxygenase inhibitors upon the in vivo metabolism and duration of action of 1-ethynylcyclohexyl carbamate

Subchronic toxicity, metabolism, and pharmacokinetics of the aminobenzamide anticonvulsant ameltolide (LY201116) in rhesus monkeys

Inhibition of drug metabolism by fluoxetine

Metabolism of para-chloroamphetamine in rats

Analysis of the Enantiomers of Fluoxetine and Norfluoxetine in Plasma and Tissue Using Chiral Derivatization and Normal-Phase Liquid Chromatography

Pyruvate metabolism in mammalian liver

Induction of drug metabolism. IV. Relative abilities of polycyclic hydrocarbons to increase levels of microsomal 3-methyl-4-methylaminoazobenzene N-demethylase activity and cytochrome P1-450

Comparison of the oxime and the hydroxylamine derivatives of 4-chloroamphetamine as depletors of brain 5-hydroxyindoles

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