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Troglitazone: the discovery and development of a novel therapy for the treatment of Type 2 diabetes mellitus

Advanced drug delivery reviews, 2002-11, Vol.54 (9), p.1173-1197

Parker, Janice C

2002

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cis-2,5-Dicyanopyrrolidine Inhibitors of Dipeptidyl Peptidase IV: Synthesis and in Vitro, in Vivo, and X-ray Crystallographic Characterization

Journal of medicinal chemistry, 2006-06, Vol.49 (11), p.3068-3076

2006

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Discovery of triazolopyrimidine-based PDE8B inhibitors: Exceptionally ligand-efficient and lipophilic ligand-efficient compounds for the treatment of diabetes

Bioorganic & medicinal chemistry letters, 2012-09, Vol.22 (17), p.5721-5726

2012

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Glycemic Control in Mice with Targeted Disruption of the Glucagon Receptor Gene

Biochemical and biophysical research communications, 2002-01, Vol.290 (2), p.839-843

2002

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Thielavins as Glucose-6-phosphatase (G6Pase) Inhibitors: Producing Strain, Fermentation, Isolation, Structural Elucidation and Biological Activities

The Journal of Antibiotics, 2002/11/25, Vol.55(11), pp.941-951

2002

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3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: a potent, selective, orally active dipeptidyl peptidase IV inhibitor

Bioorganic & medicinal chemistry letters, 2009-04, Vol.19 (7), p.1991-1995

2009

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1-((3 S,4 S)-4-Amino-1-(4-substituted-1,3,5-triazin-2-yl) pyrrolidin-3-yl)-5,5-difluoropiperidin-2-one inhibitors of DPP-4 for the treatment of type 2 diabetes

Bioorganic & medicinal chemistry letters, 2011-03, Vol.21 (6), p.1810-1814

2011

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CJ-21, 164, a New D-Glucose-6-phosphate Phosphohydrolase Inhibitor Produced by a Fungus Chloridium sp

The Journal of Antibiotics, 2002/02/25, Vol.55(2), pp.121-127

2002

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New fluorinated pyrrolidine and azetidine amides as dipeptidyl peptidase IV inhibitors

Bioorganic & medicinal chemistry letters, 2005-11, Vol.15 (21), p.4770-4773

2005

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Piperidinyl-2-phenethylamino inhibitors of DPP-IV for the treatment of Type 2 diabetes

Bioorganic & medicinal chemistry letters, 2009-04, Vol.19 (8), p.2220-2223

2009

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(3R,4S)-4-(2,4,5-Trifluorophenyl)-pyrrolidin-3-ylamine inhibitors of dipeptidyl peptidase IV: Synthesis, in vitro, in vivo, and X-ray crystallographic characterization

Bioorganic & medicinal chemistry letters, 2007-10, Vol.17 (20), p.5638-5642

2007

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Effects of skyrin, a receptor-selective glucagon antagonist, in rat and human hepatocytes

Diabetes (New York, N.Y.), 2000-12, Vol.49 (12), p.2079-2086

2000

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3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: A potent, selective, orally active dipeptidyl peptidase IV inhibitor

Bioorganic & medicinal chemistry letters, 2009-04, Vol.19 (7), p.1991-1995

2009

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Synergistic effect on insulin secretion from INS-1 cells of a sulfonylurea and a phosphodiesterase 3 inhibitor

Life sciences (1973), 2004-08, Vol.75 (12), p.1479-1490

2004

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A kinetic analysis of the effects of adrenaline on calcium distribution in isolated rat liver parenchymal cells

The Journal of physiology, 1981-03, Vol.312 (1), p.29-55

1981

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Troglitazone: the discovery and development of a novel therapy for the treatment of Type 2 diabetes mellitus: Type 2 diabetes - Delivery approaches for novel therapeutics

Advanced drug delivery reviews, 2002, Vol.54 (9), p.1173-1197

PARKER, Janice C

2002

Volltextzugriff (PDF)

Islet amyloid-associated diabetes in obese A(vy)/a mice expressing human islet amyloid polypeptide

Diabetes (New York, N.Y.), 1998-05, Vol.47 (5), p.743

1998

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A Novel Inhibitor of Dipeptidyl Peptidase IV Improves Glucose Tolerance in Models of Diabetes Mellitus

Diabetes (New York, N.Y.), 2005-06, Vol.54, p.A111

2005

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(3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone : A potent, selective, orally active dipeptidyl peptidase IV inhibitor

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (7), p.1991-1995

2009

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Plasma glucose levels are reduced in rats and mice treated with an inhibitor of glucose-6-phosphate translocase

Diabetes (New York, N.Y.), 1998-10, Vol.47 (10), p.1630

1998

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Cyclic AMP Phosphodiesterases of Human and Rat Islets of Langerhans: Contributions of Types III and IV to the Modulation of Insulin Secretion

Biochemical and biophysical research communications, 1995-12, Vol.217 (3), p.916-923

1995

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Modulation of Insulin Secretion and Glycemia by Selective Inhibition of Cyclic AMP Phosphodiesterase III

Biochemical and biophysical research communications, 1997-07, Vol.236 (3), p.665-669

1997

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Glucose-dependent action of glucagon-like peptide-1(7-37) in vivo during short- or long-term administration

Metabolism, clinical and experimental, 1995-09, Vol.44 (9), p.1231-1237

1995

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Structure-function analysis of a series of glucagon-like peptide-1 analogs

The journal of peptide research, 1998-11, Vol.52 (5), p.398-409

1998

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Analysis of the glucose transporter content of islet cell lines: Implications for glucose-stimulated insulin release

Cellular signalling, 1992-11, Vol.4 (6), p.641-650

1992

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Troglitazone: the discovery and development of a novel therapy for the treatment of Type 2 diabetes mellitus

cis-2,5-Dicyanopyrrolidine Inhibitors of Dipeptidyl Peptidase IV: Synthesis and in Vitro, in Vivo, and X-ray Crystallographic Characterization

Discovery of triazolopyrimidine-based PDE8B inhibitors: Exceptionally ligand-efficient and lipophilic ligand-efficient compounds for the treatment of diabetes

Glycemic Control in Mice with Targeted Disruption of the Glucagon Receptor Gene

Thielavins as Glucose-6-phosphatase (G6Pase) Inhibitors: Producing Strain, Fermentation, Isolation, Structural Elucidation and Biological Activities

3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: a potent, selective, orally active dipeptidyl peptidase IV inhibitor

1-((3 S,4 S)-4-Amino-1-(4-substituted-1,3,5-triazin-2-yl) pyrrolidin-3-yl)-5,5-difluoropiperidin-2-one inhibitors of DPP-4 for the treatment of type 2 diabetes

CJ-21, 164, a New D-Glucose-6-phosphate Phosphohydrolase Inhibitor Produced by a Fungus Chloridium sp

New fluorinated pyrrolidine and azetidine amides as dipeptidyl peptidase IV inhibitors

Piperidinyl-2-phenethylamino inhibitors of DPP-IV for the treatment of Type 2 diabetes

(3R,4S)-4-(2,4,5-Trifluorophenyl)-pyrrolidin-3-ylamine inhibitors of dipeptidyl peptidase IV: Synthesis, in vitro, in vivo, and X-ray crystallographic characterization

Effects of skyrin, a receptor-selective glucagon antagonist, in rat and human hepatocytes

3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: A potent, selective, orally active dipeptidyl peptidase IV inhibitor

Synergistic effect on insulin secretion from INS-1 cells of a sulfonylurea and a phosphodiesterase 3 inhibitor

A kinetic analysis of the effects of adrenaline on calcium distribution in isolated rat liver parenchymal cells

Troglitazone: the discovery and development of a novel therapy for the treatment of Type 2 diabetes mellitus: Type 2 diabetes - Delivery approaches for novel therapeutics

Islet amyloid-associated diabetes in obese A(vy)/a mice expressing human islet amyloid polypeptide

A Novel Inhibitor of Dipeptidyl Peptidase IV Improves Glucose Tolerance in Models of Diabetes Mellitus

(3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone : A potent, selective, orally active dipeptidyl peptidase IV inhibitor

Plasma glucose levels are reduced in rats and mice treated with an inhibitor of glucose-6-phosphate translocase

Cyclic AMP Phosphodiesterases of Human and Rat Islets of Langerhans: Contributions of Types III and IV to the Modulation of Insulin Secretion

Modulation of Insulin Secretion and Glycemia by Selective Inhibition of Cyclic AMP Phosphodiesterase III

Glucose-dependent action of glucagon-like peptide-1(7-37) in vivo during short- or long-term administration

Structure-function analysis of a series of glucagon-like peptide-1 analogs

Analysis of the glucose transporter content of islet cell lines: Implications for glucose-stimulated insulin release

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