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Discovery of a first-in-class EZH2 selective degrader

Nature chemical biology, 2020-02, Vol.16 (2), p.214-222

2020

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EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis

Nature cell biology, 2022-03, Vol.24 (3), p.384-399

2022

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Myricetin: biological activity related to human health

Applied Biological Chemistry, 2016, 59(2), , pp.259-269

2016

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Targeted Degradation of PRC1 Components, BMI1 and RING1B, via a Novel Protein Complex Degrader Strategy

Advanced science, 2023-04, Vol.10 (10), p.e2205573-n/a

2023

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Characterizing isotopic compositions of TC-C, NO3−-N, and NH4+-N in PM2.5 in South Korea: Impact of China's winter heating

Environmental pollution (1987), 2018-02, Vol.233, p.735-744

2018

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Advancing targeted protein degradation for cancer therapy

Nature reviews. Cancer, 2021-10, Vol.21 (10), p.638-654

2021

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A curcumin-based molecular probe for near-infrared fluorescence imaging of tau fibrils in Alzheimer's disease

Organic & biomolecular chemistry, 2015-01, Vol.13 (46), p.11194-11199

2015

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Metabolic engineering of Escherichia coli for the biosynthesis of flavonoid-O-glucuronides and flavonoid-O-galactoside

Applied microbiology and biotechnology, 2015-03, Vol.99 (5), p.2233-2242

2015

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Structure-Based Design, Docking and Binding Free Energy Calculations of A366 Derivatives as Spindlin1 Inhibitors

International journal of molecular sciences, 2021-05, Vol.22 (11), p.5910

2021

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Discovery of the First-in-Class G9a/GLP Covalent Inhibitors

Journal of medicinal chemistry, 2022-08, Vol.65 (15), p.10506-10522

2022

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A Smart Near-Infrared Fluorescence Probe for Selective Detection of Tau Fibrils in Alzheimer’s Disease

ACS chemical neuroscience, 2016-11, Vol.7 (11), p.1474-1481

2016

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Bridged Proteolysis Targeting Chimera (PROTAC) Enables Degradation of Undruggable Targets

Journal of the American Chemical Society, 2022-12, Vol.144 (49), p.22622-22632

2022

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A cryptic transactivation domain of EZH2 binds AR and AR's splice variant, promoting oncogene activation and tumorous transformation

Nucleic acids research, 2022-10, Vol.50 (19), p.10929-10946

2022

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Harnessing the E3 Ligase KEAP1 for Targeted Protein Degradation

Journal of the American Chemical Society, 2021-09, Vol.143 (37), p.15073-15083

2021

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A Novel Probe with a Chlorinated α-Cyanoacetophenone Acceptor Moiety Shows Near-Infrared Fluorescence Specific for Tau Fibrils

Chemical and Pharmaceutical Bulletin, 2017/12/01, Vol.65(12), pp.1113-1116

2017

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A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models

Science translational medicine, 2021-09, Vol.13 (613), p.eabj1578

2021

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Discovery of a First-in-Class Degrader for Nuclear Receptor Binding SET Domain Protein 2 (NSD2) and Ikaros/Aiolos

Journal of medicinal chemistry, 2022-08, Vol.65 (15), p.10611-10625

2022

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Mercury concentrations in environmental media at a hazardous solid waste landfill site and mercury emissions from the site

Environmental earth sciences, 2017-05, Vol.76 (10), p.1-14, Article 361

2017

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Discovery and Characterization of a Novel Cereblon-Recruiting PRC1 Bridged PROTAC Degrader

Journal of medicinal chemistry, 2024-04, Vol.67 (8), p.6880-6892

2024

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Discovery of Potent, Selective, and In Vivo Efficacious AKT Kinase Protein Degraders via Structure–Activity Relationship Studies

Journal of medicinal chemistry, 2022-02, Vol.65 (4), p.3644-3666

2022

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Discovery of a novel, highly potent EZH2 PROTAC degrader for targeting non-canonical oncogenic functions of EZH2

European journal of medicinal chemistry, 2024-03, Vol.267, p.116154, Article 116154

2024

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Quercetin 7-O-Glutamate Potentiates Staphylococcus aureus to Fluoroquinolone Antibiotics

Bulletin of the Korean Chemical Society, 2016, 37(9), , pp.1515-1517

2016

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Epigallocatechin‐3‐gallate (EGCG) Serves as a Novel Scaffold for Designing an Inhibitor of Plasminogen Activator Inhibitor‐1 (PAI‐1)

Bulletin of the Korean Chemical Society, 2017, 38(8), , pp.964-967

2017

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Quercetin 7-O-Glutamate Sensitizes P. aeruginosa to β-Lactams and Vancomycin

Bulletin of the Korean Chemical Society, 2016, 37(12), , pp.2025-2028

2016

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Quercetin–POC conjugates: Differential stability and bioactivity profiles between breast cancer (MCF-7) and colorectal carcinoma (HCT116) cell lines

Bioorganic & medicinal chemistry, 2013-04, Vol.21 (7), p.1671-1679

2013

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Discovery of a first-in-class EZH2 selective degrader

EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis

Myricetin: biological activity related to human health

Targeted Degradation of PRC1 Components, BMI1 and RING1B, via a Novel Protein Complex Degrader Strategy

Characterizing isotopic compositions of TC-C, NO3−-N, and NH4+-N in PM2.5 in South Korea: Impact of China's winter heating

Advancing targeted protein degradation for cancer therapy

A curcumin-based molecular probe for near-infrared fluorescence imaging of tau fibrils in Alzheimer's disease

Metabolic engineering of Escherichia coli for the biosynthesis of flavonoid-O-glucuronides and flavonoid-O-galactoside

Structure-Based Design, Docking and Binding Free Energy Calculations of A366 Derivatives as Spindlin1 Inhibitors

Discovery of the First-in-Class G9a/GLP Covalent Inhibitors

A Smart Near-Infrared Fluorescence Probe for Selective Detection of Tau Fibrils in Alzheimer’s Disease

Bridged Proteolysis Targeting Chimera (PROTAC) Enables Degradation of Undruggable Targets

A cryptic transactivation domain of EZH2 binds AR and AR's splice variant, promoting oncogene activation and tumorous transformation

Harnessing the E3 Ligase KEAP1 for Targeted Protein Degradation

A Novel Probe with a Chlorinated α-Cyanoacetophenone Acceptor Moiety Shows Near-Infrared Fluorescence Specific for Tau Fibrils

A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models

Discovery of a First-in-Class Degrader for Nuclear Receptor Binding SET Domain Protein 2 (NSD2) and Ikaros/Aiolos

Mercury concentrations in environmental media at a hazardous solid waste landfill site and mercury emissions from the site

Discovery and Characterization of a Novel Cereblon-Recruiting PRC1 Bridged PROTAC Degrader

Discovery of Potent, Selective, and In Vivo Efficacious AKT Kinase Protein Degraders via Structure–Activity Relationship Studies

Discovery of a novel, highly potent EZH2 PROTAC degrader for targeting non-canonical oncogenic functions of EZH2

Quercetin 7-O-Glutamate Potentiates Staphylococcus aureus to Fluoroquinolone Antibiotics

Epigallocatechin‐3‐gallate (EGCG) Serves as a Novel Scaffold for Designing an Inhibitor of Plasminogen Activator Inhibitor‐1 (PAI‐1)

Quercetin 7-O-Glutamate Sensitizes P. aeruginosa to β-Lactams and Vancomycin

Quercetin–POC conjugates: Differential stability and bioactivity profiles between breast cancer (MCF-7) and colorectal carcinoma (HCT116) cell lines

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