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PLAG alleviates cisplatin-induced cachexia in lung cancer implanted mice

Translational oncology, 2022-06, Vol.20, p.101398-101398, Article 101398

2022

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Abstract 1447: Suppressive effect of PLAG on tumor progression and its synergistic therapeutic effect with ICI therapy through adenosine clearance

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1447-1447

2021

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Identification of YH-GKA, a novel benzamide glucokinase activator as therapeutic candidate for type 2 diabetes mellitus

Archives of Pharmacal Research, 2012, 35(12), , pp.2029-2033

Park, Kaapjoo

2012

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Identification of novel orally available small molecule insulin mimetics

The Journal of pharmacology and experimental therapeutics, 2007-11, Vol.323 (2), p.579-585

2007

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The effect of mGlu5 receptor positive allosteric modulators on signaling molecules in brain slices

European journal of pharmacology, 2006-05, Vol.536 (3), p.262-268

2006

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Isolation and identification of eukaryotic initiation factor 4A as a molecular target for the marine natural product Pateamine A

Methods in enzymology, 2007, Vol.431, p.303

2007

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Mitigation of Hematopoietic Syndrome of Acute Radiation Syndrome by 1-Palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG) is Associated with Regulation of Systemic Inflammation in a Murine Model of Total-Body Irradiation

Radiation research, 2021-07, Vol.196 (1)

2021

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Synthesis of 3-Indolyl-2,5-dihydroxybenzoquinones

Organic letters, 2001-02, Vol.3 (3), p.365-367

2001

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Discovery of thienothiazolocarboxamide analogues as novel anti-tubercular agent

Bioorganic & medicinal chemistry, 2020-12, Vol.28 (23), p.115797, Article 115797

2020

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Design and Synthesis of Acetylenyl Benzamide Derivatives as Novel Glucokinase Activators for the Treatment of T2DM

ACS medicinal chemistry letters, 2015-03, Vol.6 (3), p.296-301

2015

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Signaling Effects of Demethylasterriquinone B1, a Selective Insulin Receptor Modulator

Chembiochem : a European journal of chemical biology, 2003-05, Vol.4 (5), p.379-385

2003

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Discovery of 3-(4-methanesulfonylphenoxy)-N-[1-(2-methoxy-ethoxymethyl)-1H-pyrazol-3-yl]-5-(3-methylpyridin-2-yl)-benzamide as a novel glucokinase activator (GKA) for the treatment of type 2 diabetes mellitus

Bioorganic & medicinal chemistry, 2014-04, Vol.22 (7), p.2280-2293

2014

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Compound 19e, a Novel Glucokinase Activator, Protects against Cytokine-Induced Beta-Cell Apoptosis in INS-1 Cells

Frontiers in pharmacology, 2017-03, Vol.8, p.169-169

2017

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Discovery of a novel phenylethyl benzamide glucokinase activator for the treatment of type 2 diabetes mellitus

Bioorganic & medicinal chemistry letters, 2013-01, Vol.23 (2), p.537-542

2013

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Abstract 5478: EC-18 suppressed tumor growth and alleviated side effects caused by cisplatin in the HNSCC implantation model

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.5478-5478

2022

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Treatment with glucokinase activator, YH-GKA, increases cell proliferation and decreases glucotoxic apoptosis in INS-1 cells

European journal of pharmaceutical sciences, 2014-01, Vol.51, p.137-145

2014

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Novel benzofuran-3-one indole inhibitors of PI3 kinase-α and the mammalian target of rapamycin: Hit to lead studies

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (8), p.2586-2590

2010

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Discovery of selective metal-binding peptoids using 19F encoded combinatorial libraries

Bioorganic & medicinal chemistry letters, 2000-09, Vol.10 (18), p.2115-2118

2000

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Synthesis and activity of tryptophan sulfonamide derivatives as novel non-hydroxamate TNF-α converting enzyme (TACE) inhibitors

Bioorganic & medicinal chemistry, 2009-06, Vol.17 (11), p.3857-3865

2009

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Novel purine and pyrazolo[3,4- d]pyrimidine inhibitors of PI3 kinase-α: Hit to lead studies

Bioorganic & medicinal chemistry letters, 2010-01, Vol.20 (2), p.636-639

2010

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Inhibition of the Signal Transducer and Activator of Transcription-3 (STAT3) Signaling Pathway by 4-Oxo-1-Phenyl-1,4-Dihydroquinoline-3-Carboxylic Acid Esters

Journal of medicinal chemistry, 2008-07, Vol.51 (14), p.4115-4121

2008

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Design and synthesis of 3,4-dihydro-1H-[1]-benzothieno[2,3-c]pyran and 3,4-dihydro-1H-pyrano[3,4-b]benzofuran derivatives as non-nucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase

Bioorganic & medicinal chemistry letters, 2006-01, Vol.16 (2), p.457-460

2006

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Discovery of Pyrano[3,4-b]indoles as Potent and Selective HCV NS5B Polymerase Inhibitors

Journal of medicinal chemistry, 2004-12, Vol.47 (26), p.6603-6608

2004

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Novel benzofuran-3-one indole inhibitors of PI3 kinase-a and the mammalian target of rapamycin: Hit to lead studies

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (8), p.2586-2590

2010

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Organometallic Routes to 2,5-Dihydroxy-3-(indol-3-yl)benzoquinones. Synthesis of Demethylasterriquinone B4

Journal of organic chemistry, 2005-04, Vol.70 (7), p.2537-2542

2005

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PLAG alleviates cisplatin-induced cachexia in lung cancer implanted mice

Abstract 1447: Suppressive effect of PLAG on tumor progression and its synergistic therapeutic effect with ICI therapy through adenosine clearance

Identification of YH-GKA, a novel benzamide glucokinase activator as therapeutic candidate for type 2 diabetes mellitus

Identification of novel orally available small molecule insulin mimetics

The effect of mGlu5 receptor positive allosteric modulators on signaling molecules in brain slices

Isolation and identification of eukaryotic initiation factor 4A as a molecular target for the marine natural product Pateamine A

Mitigation of Hematopoietic Syndrome of Acute Radiation Syndrome by 1-Palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG) is Associated with Regulation of Systemic Inflammation in a Murine Model of Total-Body Irradiation

Synthesis of 3-Indolyl-2,5-dihydroxybenzoquinones

Discovery of thienothiazolocarboxamide analogues as novel anti-tubercular agent

Design and Synthesis of Acetylenyl Benzamide Derivatives as Novel Glucokinase Activators for the Treatment of T2DM

Signaling Effects of Demethylasterriquinone B1, a Selective Insulin Receptor Modulator

Discovery of 3-(4-methanesulfonylphenoxy)-N-[1-(2-methoxy-ethoxymethyl)-1H-pyrazol-3-yl]-5-(3-methylpyridin-2-yl)-benzamide as a novel glucokinase activator (GKA) for the treatment of type 2 diabetes mellitus

Compound 19e, a Novel Glucokinase Activator, Protects against Cytokine-Induced Beta-Cell Apoptosis in INS-1 Cells

Discovery of a novel phenylethyl benzamide glucokinase activator for the treatment of type 2 diabetes mellitus

Abstract 5478: EC-18 suppressed tumor growth and alleviated side effects caused by cisplatin in the HNSCC implantation model

Treatment with glucokinase activator, YH-GKA, increases cell proliferation and decreases glucotoxic apoptosis in INS-1 cells

Novel benzofuran-3-one indole inhibitors of PI3 kinase-α and the mammalian target of rapamycin: Hit to lead studies

Discovery of selective metal-binding peptoids using 19F encoded combinatorial libraries

Synthesis and activity of tryptophan sulfonamide derivatives as novel non-hydroxamate TNF-α converting enzyme (TACE) inhibitors

Novel purine and pyrazolo[3,4- d]pyrimidine inhibitors of PI3 kinase-α: Hit to lead studies

Inhibition of the Signal Transducer and Activator of Transcription-3 (STAT3) Signaling Pathway by 4-Oxo-1-Phenyl-1,4-Dihydroquinoline-3-Carboxylic Acid Esters

Design and synthesis of 3,4-dihydro-1H-[1]-benzothieno[2,3-c]pyran and 3,4-dihydro-1H-pyrano[3,4-b]benzofuran derivatives as non-nucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase

Discovery of Pyrano[3,4-b]indoles as Potent and Selective HCV NS5B Polymerase Inhibitors

Novel benzofuran-3-one indole inhibitors of PI3 kinase-a and the mammalian target of rapamycin: Hit to lead studies

Organometallic Routes to 2,5-Dihydroxy-3-(indol-3-yl)benzoquinones. Synthesis of Demethylasterriquinone B4

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