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Preclinical approaches to assess potential kinase inhibitor‐induced cardiac toxicity: Past, present and future

Journal of applied toxicology, 2018-06, Vol.38 (6), p.790-800

2018

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Tyrosine kinase inhibitor (TKI)-induced cardiotoxicity: approaches to narrow the gaps between preclinical safety evaluation and clinical outcome

Journal of applied toxicology, 2012-12, Vol.32 (12), p.945-951

2012

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Effects of 31 FDA approved small-molecule kinase inhibitors on isolated rat liver mitochondria

Archives of toxicology, 2017-08, Vol.91 (8), p.2921-2938

2017

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Secondary pharmacology data to assess potential off-target activity of new drugs: a regulatory perspective

Nature reviews. Drug discovery, 2015-04, Vol.14 (4), p.294-294

2015

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Safety of antisense oligonucleotide and siRNA-based therapeutics

Drug discovery today, 2017-05, Vol.22 (5), p.823-833

2017

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Moving beyond the comprehensive in vitro proarrhythmia assay: Use of human‐induced pluripotent stem cell‐derived cardiomyocytes to assess contractile effects associated with drug‐induced structural cardiotoxicity

Journal of applied toxicology, 2018-09, Vol.38 (9), p.1166-1176

2018

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Cytotoxicity of 34 FDA approved small-molecule kinase inhibitors in primary rat and human hepatocytes

Toxicology letters, 2018-07, Vol.291, p.138-148

2018

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Why Collecting Pharmacokinetic Information After Intravenous Drug Administration Is Important

Clinical pharmacology in drug development, 2020-02, Vol.9 (2), p.146-150

2020

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Induced Pluripotent Stem Cell-Derived Cardiomyocytes: An In Vitro Model to Predict Tyrosine Kinase Inhibitor (TKI)-Induced Structural Cardiotoxicity

Journal of pharmacological and toxicological methods, 2017-11, Vol.88, p.243-243

2017

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Regulatory Forum Review: Utility of in Vitro Secondary Pharmacology Data to Assess Risk of Drug-induced Valvular Heart Disease in Humans: Regulatory Considerations

Toxicologic pathology, 2017-04, Vol.45 (3), p.381-388

2017

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SK&F 95654-Induced Acute Cardiovascular Toxicity in Sprague-Dawley Rats—Histopathologic, Electron Microscopic, and Immunohistochemical Studies

Toxicologic pathology, 2002-01, Vol.30 (1), p.28-40

2002

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Editorial: Genomics and Drug Toxicity

Science (American Association for the Advancement of Science), 2004-10, Vol.306 (5696), p.575-575

2004

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Genomics and drug toxicity

Science (American Association for the Advancement of Science), 2004-10, Vol.306 (5696), p.575-575

2004

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Zidovudine induces molecular, biochemical, and ultrastructural changes in rat skeletal muscle mitochondria

The Journal of clinical investigation, 1992-04, Vol.89 (4), p.1354-1360

1992

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Use of cardiac troponin T levels as an indicator of doxorubicin-induced cardiotoxicity

Cancer research (Chicago, Ill.), 1998-01, Vol.58 (2), p.195-197

1998

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Selective alterations in rat cardiac mRNA induced by doxorubicin: Possible subcellular mechanisms

Experimental and molecular pathology, 1991-04, Vol.54 (2), p.112-121

1991

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SK&F 95654-induced acute cardiovascular toxicity in Sprague-Dawley rats: Histopathologic, electron microscopic, and immunohistochemical studies : Discovery pathology; Emerging technologies

Toxicologic pathology, 2002, Vol.30 (1), p.28-40

2002

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Anthracyclines selectively decrease alpha cardiac actin mRNA abundance in the rat heart

The American journal of pathology, 1992-11, Vol.141 (5), p.1187-1195

1992

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Adriamycin cardiotoxicity in vivo. Selective alterations in rat cardiac mRNAs

The American journal of pathology, 1990-06, Vol.136 (6), p.1201-1207

1990

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Selective alterations in rat cardiac mRNAs induced by doxorubicin in vivo

Papoian, Thomas

1991

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Insulin-like activity of chromium-binding fractions from brewer's yeast

Journal of inorganic biochemistry, 1987-07, Vol.30 (3), p.219-225

1987

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Ethanolamine mimics insulin effects invitro

Biochemical and biophysical research communications, 1984-05, Vol.121 (1), p.413-419

1984

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Ethanolamine mimics insulin effects in vitro

Biochemical and biophysical research communications, 1984-05, Vol.121 (1), p.413-419

1984

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Ethanolamine mimics insulin effects [formula omitted][formula omitted]

Biochemical and biophysical research communications, 1984, Vol.121 (1), p.413-419

1984

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Preclinical approaches to assess potential kinase inhibitor‐induced cardiac toxicity: Past, present and future

Tyrosine kinase inhibitor (TKI)-induced cardiotoxicity: approaches to narrow the gaps between preclinical safety evaluation and clinical outcome

Effects of 31 FDA approved small-molecule kinase inhibitors on isolated rat liver mitochondria

Secondary pharmacology data to assess potential off-target activity of new drugs: a regulatory perspective

Safety of antisense oligonucleotide and siRNA-based therapeutics

Moving beyond the comprehensive in vitro proarrhythmia assay: Use of human‐induced pluripotent stem cell‐derived cardiomyocytes to assess contractile effects associated with drug‐induced structural cardiotoxicity

Cytotoxicity of 34 FDA approved small-molecule kinase inhibitors in primary rat and human hepatocytes

Why Collecting Pharmacokinetic Information After Intravenous Drug Administration Is Important

Induced Pluripotent Stem Cell-Derived Cardiomyocytes: An In Vitro Model to Predict Tyrosine Kinase Inhibitor (TKI)-Induced Structural Cardiotoxicity

Regulatory Forum Review: Utility of in Vitro Secondary Pharmacology Data to Assess Risk of Drug-induced Valvular Heart Disease in Humans: Regulatory Considerations

SK&F 95654-Induced Acute Cardiovascular Toxicity in Sprague-Dawley Rats—Histopathologic, Electron Microscopic, and Immunohistochemical Studies

Editorial: Genomics and Drug Toxicity

Genomics and drug toxicity

Zidovudine induces molecular, biochemical, and ultrastructural changes in rat skeletal muscle mitochondria

Chemical Effects in Biological Systems—Data Dictionary (CEBS-DD): A Compendium of Terms for the Capture and Integration of Biological Study Design Description, Conventional Phenotypes, and ‘Omics Data

Use of cardiac troponin T levels as an indicator of doxorubicin-induced cardiotoxicity

Selective alterations in rat cardiac mRNA induced by doxorubicin: Possible subcellular mechanisms

SK&F 95654-induced acute cardiovascular toxicity in Sprague-Dawley rats: Histopathologic, electron microscopic, and immunohistochemical studies : Discovery pathology; Emerging technologies

Anthracyclines selectively decrease alpha cardiac actin mRNA abundance in the rat heart

Adriamycin cardiotoxicity in vivo. Selective alterations in rat cardiac mRNAs

Selective alterations in rat cardiac mRNAs induced by doxorubicin in vivo

Insulin-like activity of chromium-binding fractions from brewer's yeast

Ethanolamine mimics insulin effects invitro

Ethanolamine mimics insulin effects in vitro

Ethanolamine mimics insulin effects [formula omitted][formula omitted]

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